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Deep brain stimulation in benign tremulous parkinsonism.
Arch Neurol. 2011 Aug; 68(8):1033-6.AN

Abstract

BACKGROUND

Benign tremulous parkinsonism (BTP) is characterized by prominent resting plus action tremor, mild parkinsonism with limited disability or progression apart from tremor, and a less-robust response to levodopa therapy. This disorder has an uncertain pathophysiologic relationship to idiopathic Parkinson disease. Deep brain stimulation (DBS) should be efficacious for this condition, but there is no previously published experience.

OBJECTIVES

To assess the clinical outcomes and surgical complications of patients with BTP who underwent DBS.

DESIGN

Retrospective case series.

SETTING

Tertiary care medical center.

PATIENTS

Twelve men and 3 women with BTP who underwent DBS for levodopa-refractory tremor.

MAIN OUTCOME MEASURES

Tremor status after DBS, preoperative vs postoperative scores on the Fahn-Tolosa-Marin tremor scale, and the presence of adverse events.

RESULTS

Of the 15 patients, 8 underwent unilateral thalamic nucleus ventralis intermedius (VIM), 4 bilateral VIM, and 3 bilateral subthalamic nucleus DBS. At last follow-up at a median of 4 years post-DBS, 7 patients were tremor free, 6 had only trace tremor, and 2 were definitely improved but with residual tremor. The median preoperative Fahn-Tolosa-Marin tremor scale score was 17 (range, 11-21); the tremor scale score at the last videotaped follow-up was 1 (range, 0-6). Median time between the 2 videotapes was 11.5 months (range, 3-14 months). No patients experienced adverse events after the surgical procedure.

CONCLUSIONS

These findings support the efficacy of DBS, with VIM and STN targets, in medically refractory BTP-related tremor. Further studies are needed to explore the long-term durability of response and to better compare the surgical targets.

Authors+Show Affiliations

Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21825239

Citation

Savica, Rodolfo, et al. "Deep Brain Stimulation in Benign Tremulous Parkinsonism." Archives of Neurology, vol. 68, no. 8, 2011, pp. 1033-6.
Savica R, Matsumoto JY, Josephs KA, et al. Deep brain stimulation in benign tremulous parkinsonism. Arch Neurol. 2011;68(8):1033-6.
Savica, R., Matsumoto, J. Y., Josephs, K. A., Ahlskog, J. E., Stead, M., Lee, K. H., & Klassen, B. T. (2011). Deep brain stimulation in benign tremulous parkinsonism. Archives of Neurology, 68(8), 1033-6. https://doi.org/10.1001/archneurol.2011.160
Savica R, et al. Deep Brain Stimulation in Benign Tremulous Parkinsonism. Arch Neurol. 2011;68(8):1033-6. PubMed PMID: 21825239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep brain stimulation in benign tremulous parkinsonism. AU - Savica,Rodolfo, AU - Matsumoto,Joseph Y, AU - Josephs,Keith A, AU - Ahlskog,J Eric, AU - Stead,Matt, AU - Lee,Kendall H, AU - Klassen,Bryan T, PY - 2011/8/10/entrez PY - 2011/8/10/pubmed PY - 2011/10/14/medline SP - 1033 EP - 6 JF - Archives of neurology JO - Arch Neurol VL - 68 IS - 8 N2 - BACKGROUND: Benign tremulous parkinsonism (BTP) is characterized by prominent resting plus action tremor, mild parkinsonism with limited disability or progression apart from tremor, and a less-robust response to levodopa therapy. This disorder has an uncertain pathophysiologic relationship to idiopathic Parkinson disease. Deep brain stimulation (DBS) should be efficacious for this condition, but there is no previously published experience. OBJECTIVES: To assess the clinical outcomes and surgical complications of patients with BTP who underwent DBS. DESIGN: Retrospective case series. SETTING: Tertiary care medical center. PATIENTS: Twelve men and 3 women with BTP who underwent DBS for levodopa-refractory tremor. MAIN OUTCOME MEASURES: Tremor status after DBS, preoperative vs postoperative scores on the Fahn-Tolosa-Marin tremor scale, and the presence of adverse events. RESULTS: Of the 15 patients, 8 underwent unilateral thalamic nucleus ventralis intermedius (VIM), 4 bilateral VIM, and 3 bilateral subthalamic nucleus DBS. At last follow-up at a median of 4 years post-DBS, 7 patients were tremor free, 6 had only trace tremor, and 2 were definitely improved but with residual tremor. The median preoperative Fahn-Tolosa-Marin tremor scale score was 17 (range, 11-21); the tremor scale score at the last videotaped follow-up was 1 (range, 0-6). Median time between the 2 videotapes was 11.5 months (range, 3-14 months). No patients experienced adverse events after the surgical procedure. CONCLUSIONS: These findings support the efficacy of DBS, with VIM and STN targets, in medically refractory BTP-related tremor. Further studies are needed to explore the long-term durability of response and to better compare the surgical targets. SN - 1538-3687 UR - https://www.unboundmedicine.com/medline/citation/21825239/Deep_brain_stimulation_in_benign_tremulous_parkinsonism_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneurol.2011.160 DB - PRIME DP - Unbound Medicine ER -