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Allergens in household dust and serological indicators of atopy and sensitization in Detroit children with history-based evidence of asthma.
J Asthma 2011; 48(7):674-84JA

Abstract

BACKGROUND

Home exposure to allergens is an important factor in the development of sensitization and subsequent exacerbations of allergic asthma. We investigated linkages among allergen exposure, immunological measurements, and asthma by examining (1) reservoir dust allergen levels in homes, (2) associations between presence of allergens in homes and sensitization status of resident children, and (3) associations between asthma status and total IgE, atopy (by Phadiatop), and positive allergen-specific tests.

METHODS

The study protocol was approved by Institutional Review Boards (IRBs) of the University of North Carolina Chapel Hill; Westat, Inc.; and the US Environmental Protection Agency Human Research Protocol Office. Data were collected from questionnaires, serum analyses, and household vacuum dust. Children (n = 205) were predominately African American (AA) (85.4%) and 51.6% were asthmatic. Sera from 185 children and home dust samples (n = 141) were analyzed for total and specific IgE antibodies to allergens from cat and dog dander, cockroach, dust mites, mice, rats, and molds.

RESULTS

Sixty percent of the homes had detectable levels of three or more dust allergens. The proportions of children with positive allergen-specific IgE tests were dust mite (32%), dog (28%), cat (23%), cockroach (18%), mouse (5%), rat (4%), and molds (24-36%). Children testing positive to a single allergen also had positive responses to other allergens. Those children with positive serum tests for cat, dog, and dust mite lived in homes with detectable levels of cat (51%), dog (90%), and dust mite (Der f 1) (92%) allergens. Correlations between children's specific IgE levels and dust levels were linearly related for dog (p < .04), but not for cat (p = .12) or dust mite (Der f 1) (p = .21). Odds ratios (95% CI) for the associations between asthma and serum-specific IgE were over 1.0 for cat, dog, dust mite (Der f 1), cockroach, and four types of molds. House dust allergen exposure levels, however, exhibited no differences between asthmatic and non-asthmatic homes.

CONCLUSIONS

Both the co-occurrence of multiple allergens in dust and the high frequency of multiple allergen sensitizations indicate that a broad-based intervention aimed at reducing multiple allergens (pets, pests, and molds) would be more successful than any approach that aimed at reducing one type of allergen.

Authors+Show Affiliations

Epidemiology Branch, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA. williams.annh@epa.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21827376

Citation

Williams, Ann Houston, et al. "Allergens in Household Dust and Serological Indicators of Atopy and Sensitization in Detroit Children With History-based Evidence of Asthma." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 48, no. 7, 2011, pp. 674-84.
Williams AH, Smith JT, Hudgens EE, et al. Allergens in household dust and serological indicators of atopy and sensitization in Detroit children with history-based evidence of asthma. J Asthma. 2011;48(7):674-84.
Williams, A. H., Smith, J. T., Hudgens, E. E., Rhoney, S., Ozkaynak, H., Hamilton, R. G., & Gallagher, J. E. (2011). Allergens in household dust and serological indicators of atopy and sensitization in Detroit children with history-based evidence of asthma. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 48(7), pp. 674-84. doi:10.3109/02770903.2011.599909.
Williams AH, et al. Allergens in Household Dust and Serological Indicators of Atopy and Sensitization in Detroit Children With History-based Evidence of Asthma. J Asthma. 2011;48(7):674-84. PubMed PMID: 21827376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allergens in household dust and serological indicators of atopy and sensitization in Detroit children with history-based evidence of asthma. AU - Williams,Ann Houston, AU - Smith,James Travis, AU - Hudgens,Edward E, AU - Rhoney,Scott, AU - Ozkaynak,Hal슩k, AU - Hamilton,Robert G, AU - Gallagher,Jane E, Y1 - 2011/08/10/ PY - 2011/8/11/entrez PY - 2011/8/11/pubmed PY - 2011/10/25/medline SP - 674 EP - 84 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 48 IS - 7 N2 - BACKGROUND: Home exposure to allergens is an important factor in the development of sensitization and subsequent exacerbations of allergic asthma. We investigated linkages among allergen exposure, immunological measurements, and asthma by examining (1) reservoir dust allergen levels in homes, (2) associations between presence of allergens in homes and sensitization status of resident children, and (3) associations between asthma status and total IgE, atopy (by Phadiatop), and positive allergen-specific tests. METHODS: The study protocol was approved by Institutional Review Boards (IRBs) of the University of North Carolina Chapel Hill; Westat, Inc.; and the US Environmental Protection Agency Human Research Protocol Office. Data were collected from questionnaires, serum analyses, and household vacuum dust. Children (n = 205) were predominately African American (AA) (85.4%) and 51.6% were asthmatic. Sera from 185 children and home dust samples (n = 141) were analyzed for total and specific IgE antibodies to allergens from cat and dog dander, cockroach, dust mites, mice, rats, and molds. RESULTS: Sixty percent of the homes had detectable levels of three or more dust allergens. The proportions of children with positive allergen-specific IgE tests were dust mite (32%), dog (28%), cat (23%), cockroach (18%), mouse (5%), rat (4%), and molds (24-36%). Children testing positive to a single allergen also had positive responses to other allergens. Those children with positive serum tests for cat, dog, and dust mite lived in homes with detectable levels of cat (51%), dog (90%), and dust mite (Der f 1) (92%) allergens. Correlations between children's specific IgE levels and dust levels were linearly related for dog (p < .04), but not for cat (p = .12) or dust mite (Der f 1) (p = .21). Odds ratios (95% CI) for the associations between asthma and serum-specific IgE were over 1.0 for cat, dog, dust mite (Der f 1), cockroach, and four types of molds. House dust allergen exposure levels, however, exhibited no differences between asthmatic and non-asthmatic homes. CONCLUSIONS: Both the co-occurrence of multiple allergens in dust and the high frequency of multiple allergen sensitizations indicate that a broad-based intervention aimed at reducing multiple allergens (pets, pests, and molds) would be more successful than any approach that aimed at reducing one type of allergen. SN - 1532-4303 UR - https://www.unboundmedicine.com/medline/citation/21827376/Allergens_in_household_dust_and_serological_indicators_of_atopy_and_sensitization_in_Detroit_children_with_history_based_evidence_of_asthma_ L2 - http://www.tandfonline.com/doi/full/10.3109/02770903.2011.599909 DB - PRIME DP - Unbound Medicine ER -