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Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity.
FEBS Lett. 2011 Sep 02; 585(17):2744-8.FL

Abstract

Heat shock transcription factor (HSF), a key regulator in the expression of heat shock protein (HSP) chaperones, is involved in the maintenance of protein homeostasis. However, the impact of HSF-mediated transcription of each HSP gene on this process is not fully understood. We show that Saccharomyces cerevisiae cells containing mutations in the HSF-binding sequences of chromosomal HSP90 promoters exhibit various phenotypes, including slow growth, proteotoxic stress sensitivity, and reduced chronological lifespan. Similar phenotypes were observed when HSF-binding sequences in five mitochondrial HSP promoters were mutated. Therefore, HSF-regulated changes in expression of these chaperone genes are necessary to maintain cell viability under various growth conditions.

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Authors+Show Affiliations

Sakurai H
Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan. sakurai@kenroku.kanazawa-u.ac.jp
Ota A
No affiliation info available

MeSH

Azetidinecarboxylic AcidCell SurvivalDNA-Binding ProteinsDiamideEthanolGene Expression Regulation, FungalHeat Shock Transcription FactorsHeat-Shock ProteinsProtein KinasesReverse Transcriptase Polymerase Chain ReactionSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTemperatureTranscription FactorsVitamin K 3

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21827755

Citation

Sakurai, Hiroshi, and Azumi Ota. "Regulation of Chaperone Gene Expression By Heat Shock Transcription Factor in Saccharomyces Cerevisiae: Importance in Normal Cell Growth, Stress Resistance, and Longevity." FEBS Letters, vol. 585, no. 17, 2011, pp. 2744-8.
Sakurai H, Ota A. Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity. FEBS Lett. 2011;585(17):2744-8.
Sakurai, H., & Ota, A. (2011). Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity. FEBS Letters, 585(17), 2744-8. https://doi.org/10.1016/j.febslet.2011.07.041
Sakurai H, Ota A. Regulation of Chaperone Gene Expression By Heat Shock Transcription Factor in Saccharomyces Cerevisiae: Importance in Normal Cell Growth, Stress Resistance, and Longevity. FEBS Lett. 2011 Sep 2;585(17):2744-8. PubMed PMID: 21827755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity. AU - Sakurai,Hiroshi, AU - Ota,Azumi, Y1 - 2011/08/04/ PY - 2011/06/21/received PY - 2011/07/21/revised PY - 2011/07/27/accepted PY - 2011/8/11/entrez PY - 2011/8/11/pubmed PY - 2011/10/28/medline SP - 2744 EP - 8 JF - FEBS letters JO - FEBS Lett VL - 585 IS - 17 N2 - Heat shock transcription factor (HSF), a key regulator in the expression of heat shock protein (HSP) chaperones, is involved in the maintenance of protein homeostasis. However, the impact of HSF-mediated transcription of each HSP gene on this process is not fully understood. We show that Saccharomyces cerevisiae cells containing mutations in the HSF-binding sequences of chromosomal HSP90 promoters exhibit various phenotypes, including slow growth, proteotoxic stress sensitivity, and reduced chronological lifespan. Similar phenotypes were observed when HSF-binding sequences in five mitochondrial HSP promoters were mutated. Therefore, HSF-regulated changes in expression of these chaperone genes are necessary to maintain cell viability under various growth conditions. SN - 1873-3468 UR - https://www.unboundmedicine.com/medline/citation/21827755/Regulation_of_chaperone_gene_expression_by_heat_shock_transcription_factor_in_Saccharomyces_cerevisiae:_importance_in_normal_cell_growth_stress_resistance_and_longevity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(11)00570-9 DB - PRIME DP - Unbound Medicine ER -