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Serious adverse events following receipt of trivalent inactivated influenza vaccine in Korea, 2003-2010.
Vaccine. 2011 Oct 13; 29(44):7727-32.V

Abstract

BACKGROUND

Vaccination is very important for the control and prevention of influenza, yet no vaccine is perfectly safe. Little is known, however, about influenza vaccination-associated serious adverse events following immunization (AEFI). This study aimed to identify background information on influenza vaccination-related serious AEFI in Korea.

METHODS

Retrospective review of data from Korea National Vaccine Injury Compensation Program from 2003 to 2010.

RESULTS

Distribution of approximately 75 million doses of influenza vaccine by end of 2010 gave rise to 42 potentially serious AEFI. In all, nine Guillain-Barré syndrome, eighteen other neurologic events, eight local events, and seven miscellaneous events were included. 62% of these events were identified to have unlike causal association with the vaccine. The reporting rate of serious AEFI ranged from 0.006 to 0.07 cases per 100,000 distributed doses of the vaccine.

CONCLUSION

GBS was the most common influenza vaccination-related serious AEFI. Enhancing post-vaccination GBS surveillance may increase public confidence in future routine and pandemic influenza vaccination.

Authors+Show Affiliations

Division of Vaccine Preventable Disease Control and National Immunization Program, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea. choeyj@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21827815

Citation

Choe, Young June, et al. "Serious Adverse Events Following Receipt of Trivalent Inactivated Influenza Vaccine in Korea, 2003-2010." Vaccine, vol. 29, no. 44, 2011, pp. 7727-32.
Choe YJ, Cho H, Kim SN, et al. Serious adverse events following receipt of trivalent inactivated influenza vaccine in Korea, 2003-2010. Vaccine. 2011;29(44):7727-32.
Choe, Y. J., Cho, H., Kim, S. N., Bae, G. R., & Lee, J. K. (2011). Serious adverse events following receipt of trivalent inactivated influenza vaccine in Korea, 2003-2010. Vaccine, 29(44), 7727-32. https://doi.org/10.1016/j.vaccine.2011.07.129
Choe YJ, et al. Serious Adverse Events Following Receipt of Trivalent Inactivated Influenza Vaccine in Korea, 2003-2010. Vaccine. 2011 Oct 13;29(44):7727-32. PubMed PMID: 21827815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serious adverse events following receipt of trivalent inactivated influenza vaccine in Korea, 2003-2010. AU - Choe,Young June, AU - Cho,Heeyeon, AU - Kim,Sung Nam, AU - Bae,Geun-Ryang, AU - Lee,Jong-Koo, Y1 - 2011/08/07/ PY - 2011/05/25/received PY - 2011/07/27/revised PY - 2011/07/27/accepted PY - 2011/8/11/entrez PY - 2011/8/11/pubmed PY - 2012/1/24/medline SP - 7727 EP - 32 JF - Vaccine JO - Vaccine VL - 29 IS - 44 N2 - BACKGROUND: Vaccination is very important for the control and prevention of influenza, yet no vaccine is perfectly safe. Little is known, however, about influenza vaccination-associated serious adverse events following immunization (AEFI). This study aimed to identify background information on influenza vaccination-related serious AEFI in Korea. METHODS: Retrospective review of data from Korea National Vaccine Injury Compensation Program from 2003 to 2010. RESULTS: Distribution of approximately 75 million doses of influenza vaccine by end of 2010 gave rise to 42 potentially serious AEFI. In all, nine Guillain-Barré syndrome, eighteen other neurologic events, eight local events, and seven miscellaneous events were included. 62% of these events were identified to have unlike causal association with the vaccine. The reporting rate of serious AEFI ranged from 0.006 to 0.07 cases per 100,000 distributed doses of the vaccine. CONCLUSION: GBS was the most common influenza vaccination-related serious AEFI. Enhancing post-vaccination GBS surveillance may increase public confidence in future routine and pandemic influenza vaccination. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21827815/Serious_adverse_events_following_receipt_of_trivalent_inactivated_influenza_vaccine_in_Korea_2003_2010_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)01179-0 DB - PRIME DP - Unbound Medicine ER -