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Pru p 3-sensitised Italian peach-allergic patients are less likely to develop severe symptoms when also presenting IgE antibodies to Pru p 1 and Pru p 4.
Int Arch Allergy Immunol. 2011; 156(4):362-72.IA

Abstract

BACKGROUND

The roles played by different peach allergens with respect to symptom severity have not been completely ascertained. We have evaluated the diagnostic efficacy of peach recombinant allergens ImmunoCAP compared to peach in the identification of subjects at an increased risk for severe reactions to peaches.

METHODS

148 peach-allergic patients were divided based on their symptom severity into 2 groups: mild oral allergy syndrome (OAS) and severe OAS. Anti-rPru p 1, 3 and 4 IgE levels were measured. Statistical analyses were carried out using parametric and non-parametric tests.

RESULTS

anti-rPru p 1 and anti-rPru p 4 IgE levels were significantly higher in patients with mild OAS than in patients with severe OAS (p = 0.0001); in contrast, anti-rPru p 3 IgE levels were significantly higher in patients with severe OAS than in patients with mild OAS (p < 0.00005). Moreover, we found that any unitary increase in anti-rPru p 1 IgE values corresponded to a 2.48% reduction in the odds of having severe OAS (p = 0.048), whereas any unitary increase in anti-rPru p 3 IgE values corresponded to a 9.02% increase in the probability of having severe OAS (p = 0.001). Unexpectedly, we found that patients positive to rPru p 3 as well as rPru p 1 and 4 demonstrated a significant reduction of the odds of developing severe symptoms than those positive to rPru p 3 alone. Anti-rPru p 3 IgE levels were a significantly better indicator than anti-peach IgE values (p = 0.016) of patients with the highest risk for severe OAS. A cutoff of 2.69 kUA/l for anti-rPru p 3 IgE values better discriminated peach-allergic patients at a higher risk for symptoms.

CONCLUSIONS

Italian patients with positive anti-rPru p 1, 4 and 3 IgE levels seemed less likely to experience the clinical effects of high anti-rPru p 3 IgE values.

Authors+Show Affiliations

Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21829031

Citation

Pastorello, Elide A., et al. "Pru P 3-sensitised Italian Peach-allergic Patients Are Less Likely to Develop Severe Symptoms when Also Presenting IgE Antibodies to Pru P 1 and Pru P 4." International Archives of Allergy and Immunology, vol. 156, no. 4, 2011, pp. 362-72.
Pastorello EA, Farioli L, Pravettoni V, et al. Pru p 3-sensitised Italian peach-allergic patients are less likely to develop severe symptoms when also presenting IgE antibodies to Pru p 1 and Pru p 4. Int Arch Allergy Immunol. 2011;156(4):362-72.
Pastorello, E. A., Farioli, L., Pravettoni, V., Scibilia, J., Mascheri, A., Borgonovo, L., Piantanida, M., Primavesi, L., Stafylaraki, C., Pasqualetti, S., Schroeder, J., Nichelatti, M., & Marocchi, A. (2011). Pru p 3-sensitised Italian peach-allergic patients are less likely to develop severe symptoms when also presenting IgE antibodies to Pru p 1 and Pru p 4. International Archives of Allergy and Immunology, 156(4), 362-72. https://doi.org/10.1159/000324440
Pastorello EA, et al. Pru P 3-sensitised Italian Peach-allergic Patients Are Less Likely to Develop Severe Symptoms when Also Presenting IgE Antibodies to Pru P 1 and Pru P 4. Int Arch Allergy Immunol. 2011;156(4):362-72. PubMed PMID: 21829031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pru p 3-sensitised Italian peach-allergic patients are less likely to develop severe symptoms when also presenting IgE antibodies to Pru p 1 and Pru p 4. AU - Pastorello,Elide A, AU - Farioli,Laura, AU - Pravettoni,Valerio, AU - Scibilia,Joseph, AU - Mascheri,Ambra, AU - Borgonovo,Linda, AU - Piantanida,Marta, AU - Primavesi,Laura, AU - Stafylaraki,Chrysi, AU - Pasqualetti,Sara, AU - Schroeder,Jan, AU - Nichelatti,Michele, AU - Marocchi,Alessandro, Y1 - 2011/08/09/ PY - 2010/07/22/received PY - 2011/01/10/accepted PY - 2011/8/11/entrez PY - 2011/8/11/pubmed PY - 2012/1/11/medline SP - 362 EP - 72 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 156 IS - 4 N2 - BACKGROUND: The roles played by different peach allergens with respect to symptom severity have not been completely ascertained. We have evaluated the diagnostic efficacy of peach recombinant allergens ImmunoCAP compared to peach in the identification of subjects at an increased risk for severe reactions to peaches. METHODS: 148 peach-allergic patients were divided based on their symptom severity into 2 groups: mild oral allergy syndrome (OAS) and severe OAS. Anti-rPru p 1, 3 and 4 IgE levels were measured. Statistical analyses were carried out using parametric and non-parametric tests. RESULTS: anti-rPru p 1 and anti-rPru p 4 IgE levels were significantly higher in patients with mild OAS than in patients with severe OAS (p = 0.0001); in contrast, anti-rPru p 3 IgE levels were significantly higher in patients with severe OAS than in patients with mild OAS (p < 0.00005). Moreover, we found that any unitary increase in anti-rPru p 1 IgE values corresponded to a 2.48% reduction in the odds of having severe OAS (p = 0.048), whereas any unitary increase in anti-rPru p 3 IgE values corresponded to a 9.02% increase in the probability of having severe OAS (p = 0.001). Unexpectedly, we found that patients positive to rPru p 3 as well as rPru p 1 and 4 demonstrated a significant reduction of the odds of developing severe symptoms than those positive to rPru p 3 alone. Anti-rPru p 3 IgE levels were a significantly better indicator than anti-peach IgE values (p = 0.016) of patients with the highest risk for severe OAS. A cutoff of 2.69 kUA/l for anti-rPru p 3 IgE values better discriminated peach-allergic patients at a higher risk for symptoms. CONCLUSIONS: Italian patients with positive anti-rPru p 1, 4 and 3 IgE levels seemed less likely to experience the clinical effects of high anti-rPru p 3 IgE values. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/21829031/Pru_p_3_sensitised_Italian_peach_allergic_patients_are_less_likely_to_develop_severe_symptoms_when_also_presenting_IgE_antibodies_to_Pru_p_1_and_Pru_p_4_ L2 - https://www.karger.com?DOI=10.1159/000324440 DB - PRIME DP - Unbound Medicine ER -