Tags

Type your tag names separated by a space and hit enter

Serum levels of antimüllerian hormone in women with regular menstrual cycles.
Acta Clin Croat. 2010 Dec; 49(4):405-9.AC

Abstract

Antimüllerian hormone (AMH) is produced by Sertolli cells of the testes and granulosa cells of the ovaries. Recent studies have indicated that AMH may be a novel measure of ovarian reserve. Also, earlier reports have presented minimal fluctuations ofAMH levels throughout the menstrual cycle. The aim of this preliminary study was to demonstrate the relation of serum AMH levels and age in women with regular menstrual cycles and normal hormonal regulation of ovarian function. The study included 35 women divided into two groups of women aged 30 or younger and those older than 30. Hormone concentrations were assessed by measurements of lutropin (LH), follitropin (FSH), estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG) and AMH on cycle day 3-5 (follicular phase); and LH, FSH and E2 on cycle day 13-15 (ovulation). Progesterone level was determined on cycle day 19-23 (luteal phase). Median age differed significantly between the two groups of study subjects (P = 0.001). Study results confirmed regular ovarian response to physiological gonadotropin stimulation, which is the assumption for normo-ovulatory cycles. Some decrease in the mean serum AMH levels was recorded in women over 30 years of age, although the difference was not statistically significant (P = 0.0693). There was no statistically significant difference in serum AMH concentrations between follicular phase and ovulation in study women (P = 0.3124). Our preliminary results, although obtained in a limited number of women, support the diagnostic value of AMH as a reliable marker of ovarian reserve.

Authors+Show Affiliations

Laboratory of Endocrinology, University Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital, Zagreb, Croatia. ikulas@kbsm.hrNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21830451

Citation

Zec, Ivana, et al. "Serum Levels of Antimüllerian Hormone in Women With Regular Menstrual Cycles." Acta Clinica Croatica, vol. 49, no. 4, 2010, pp. 405-9.
Zec I, Tislarić-Medenjak D, Bukovec-Megla Z, et al. Serum levels of antimüllerian hormone in women with regular menstrual cycles. Acta Clin Croat. 2010;49(4):405-9.
Zec, I., Tislarić-Medenjak, D., Bukovec-Megla, Z., Harni, V., & Kusić, Z. (2010). Serum levels of antimüllerian hormone in women with regular menstrual cycles. Acta Clinica Croatica, 49(4), 405-9.
Zec I, et al. Serum Levels of Antimüllerian Hormone in Women With Regular Menstrual Cycles. Acta Clin Croat. 2010;49(4):405-9. PubMed PMID: 21830451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of antimüllerian hormone in women with regular menstrual cycles. AU - Zec,Ivana, AU - Tislarić-Medenjak,Dubravka, AU - Bukovec-Megla,Zeljka, AU - Harni,Vesna, AU - Kusić,Zvonko, PY - 2011/8/12/entrez PY - 2011/8/13/pubmed PY - 2011/9/16/medline SP - 405 EP - 9 JF - Acta clinica Croatica JO - Acta Clin Croat VL - 49 IS - 4 N2 - Antimüllerian hormone (AMH) is produced by Sertolli cells of the testes and granulosa cells of the ovaries. Recent studies have indicated that AMH may be a novel measure of ovarian reserve. Also, earlier reports have presented minimal fluctuations ofAMH levels throughout the menstrual cycle. The aim of this preliminary study was to demonstrate the relation of serum AMH levels and age in women with regular menstrual cycles and normal hormonal regulation of ovarian function. The study included 35 women divided into two groups of women aged 30 or younger and those older than 30. Hormone concentrations were assessed by measurements of lutropin (LH), follitropin (FSH), estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG) and AMH on cycle day 3-5 (follicular phase); and LH, FSH and E2 on cycle day 13-15 (ovulation). Progesterone level was determined on cycle day 19-23 (luteal phase). Median age differed significantly between the two groups of study subjects (P = 0.001). Study results confirmed regular ovarian response to physiological gonadotropin stimulation, which is the assumption for normo-ovulatory cycles. Some decrease in the mean serum AMH levels was recorded in women over 30 years of age, although the difference was not statistically significant (P = 0.0693). There was no statistically significant difference in serum AMH concentrations between follicular phase and ovulation in study women (P = 0.3124). Our preliminary results, although obtained in a limited number of women, support the diagnostic value of AMH as a reliable marker of ovarian reserve. SN - 0353-9466 UR - https://www.unboundmedicine.com/medline/citation/21830451/Serum_levels_of_antimüllerian_hormone_in_women_with_regular_menstrual_cycles_ DB - PRIME DP - Unbound Medicine ER -