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Effects of lowering [Na+]o and [K+]o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices.
Neurosci Lett. 1990 Mar 02; 110(1-2):60-5.NL

Abstract

Changes in extracellular ([Na+]o) and calcium ([Ca2+]o) concentration evoked by quisqualate (Quis), applied iontophoretically, were measured in rat hippocampal slices. Following an initial decrease in [Ca2+]o, Quis causes a post-application overshoot, which may reflect Ca2+ extrusion from cells by the Na+/Ca2+ exchanger. To test this hypothesis, the effects of directly and indirectly reduced transmembrane Na+ gradients on these Quis-induced Ca2+ overshoots were investigated. In all cases the post-application overshoots were reduced. This suggests that the Na+/Ca2+ exchanger is involved in the production of these Quis-induced Ca2+ overshoots which may have important implications for understanding how various types of glutamate receptors differ in their capability to trigger Ca2(+)-activated processes.

Authors+Show Affiliations

Institut für Neurophysiologie, Universität zu Köln, Cologne, F.R.G.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2183088

Citation

Stabel, J, et al. "Effects of Lowering [Na+]o and [K+]o and of Ouabain On Quisqualate-induced Ionic Changes in Area CA1 of Rat Hippocampal Slices." Neuroscience Letters, vol. 110, no. 1-2, 1990, pp. 60-5.
Stabel J, Arens J, Lambert JD, et al. Effects of lowering [Na+]o and [K+]o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices. Neurosci Lett. 1990;110(1-2):60-5.
Stabel, J., Arens, J., Lambert, J. D., & Heinemann, U. (1990). Effects of lowering [Na+]o and [K+]o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices. Neuroscience Letters, 110(1-2), 60-5.
Stabel J, et al. Effects of Lowering [Na+]o and [K+]o and of Ouabain On Quisqualate-induced Ionic Changes in Area CA1 of Rat Hippocampal Slices. Neurosci Lett. 1990 Mar 2;110(1-2):60-5. PubMed PMID: 2183088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of lowering [Na+]o and [K+]o and of ouabain on quisqualate-induced ionic changes in area CA1 of rat hippocampal slices. AU - Stabel,J, AU - Arens,J, AU - Lambert,J D, AU - Heinemann,U, PY - 1990/3/2/pubmed PY - 1990/3/2/medline PY - 1990/3/2/entrez SP - 60 EP - 5 JF - Neuroscience letters JO - Neurosci Lett VL - 110 IS - 1-2 N2 - Changes in extracellular ([Na+]o) and calcium ([Ca2+]o) concentration evoked by quisqualate (Quis), applied iontophoretically, were measured in rat hippocampal slices. Following an initial decrease in [Ca2+]o, Quis causes a post-application overshoot, which may reflect Ca2+ extrusion from cells by the Na+/Ca2+ exchanger. To test this hypothesis, the effects of directly and indirectly reduced transmembrane Na+ gradients on these Quis-induced Ca2+ overshoots were investigated. In all cases the post-application overshoots were reduced. This suggests that the Na+/Ca2+ exchanger is involved in the production of these Quis-induced Ca2+ overshoots which may have important implications for understanding how various types of glutamate receptors differ in their capability to trigger Ca2(+)-activated processes. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/2183088/Effects_of_lowering_[Na+]o_and_[K+]o_and_of_ouabain_on_quisqualate_induced_ionic_changes_in_area_CA1_of_rat_hippocampal_slices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3940(90)90787-A DB - PRIME DP - Unbound Medicine ER -