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Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009.
J Clin Endocrinol Metab. 2011 Oct; 96(10):3250-6.JC

Abstract

BACKGROUND

An association between vitamin D status and sarcopenia has not been shown in a community-dwelling cohort, despite the well-documented relationship between vitamin D status and falls.

OBJECTIVE

Our objective was to investigate whether vitamin D level is associated with sarcopenia in older Koreans.

DESIGN AND SETTING

The Fourth Korea National Health and Nutrition Examination Survey in the Korean population was conducted in 2009.

PARTICIPANTS

Participants included 1380 men and 1789 women aged 50 yr or older.

MEASUREMENTS

Serum 25-hydroxyvitamin D [25(OH)D] and PTH levels were measured. Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight that was less than 2 sd below the sex-specific mean for young adults. Obesity was defined as a body mass index (BMI) of 27.5 kg/m(2) or higher.

RESULTS

25(OH)D level correlated negatively with appendicular fat mass and positively with appendicular skeletal mass. The groups with sarcopenic obesity and sarcopenia only had lower 25(OH)D levels than did the nonsarcopenia groups. However, 25(OH)D levels did not differ between the sarcopenic obesity and sarcopenia groups. After adjustment for age, sex, BMI, and lifestyle factors, compared with those in the lowest quartile of 25(OH)D level, participants in the highest quartile had an odds ratio for sarcopenia of 0.47 (95% confidence interval = 0.30-0.73; P for trend = 0.001). There was no association between PTH and sarcopenia after adjustment of BMI.

CONCLUSIONS

Vitamin D levels were significantly lower in subjects with sarcopenia than in those without, regardless of obesity. We found a strong inverse association between 25(OH)D level and sarcopenia in the older Korean population.

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    Authors+Show Affiliations

    Kim MK
    Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
    Baek KH
    No affiliation info available
    Song KH
    No affiliation info available
    Il Kang M
    No affiliation info available
    Park CY
    No affiliation info available
    Lee WY
    No affiliation info available
    Oh KW
    No affiliation info available

    MeSH

    25-Hydroxyvitamin D 2AgedAsian Continental Ancestry GroupBody Mass IndexCalcifediolCross-Sectional StudiesFemaleHealth SurveysHumansMaleMiddle AgedNutrition SurveysObesityParathyroid HormoneRepublic of KoreaRisk FactorsSarcopeniaVitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21832109

    Citation

    Kim, Mee Kyoung, et al. "Vitamin D Deficiency Is Associated With Sarcopenia in Older Koreans, Regardless of Obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009." The Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 10, 2011, pp. 3250-6.
    Kim MK, Baek KH, Song KH, et al. Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. J Clin Endocrinol Metab. 2011;96(10):3250-6.
    Kim, M. K., Baek, K. H., Song, K. H., Il Kang, M., Park, C. Y., Lee, W. Y., & Oh, K. W. (2011). Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. The Journal of Clinical Endocrinology and Metabolism, 96(10), 3250-6. https://doi.org/10.1210/jc.2011-1602
    Kim MK, et al. Vitamin D Deficiency Is Associated With Sarcopenia in Older Koreans, Regardless of Obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. J Clin Endocrinol Metab. 2011;96(10):3250-6. PubMed PMID: 21832109.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. AU - Kim,Mee Kyoung, AU - Baek,Ki Hyun, AU - Song,Ki-Ho, AU - Il Kang,Moo, AU - Park,Cheol Young, AU - Lee,Won Young, AU - Oh,Ki Won, Y1 - 2011/08/10/ PY - 2011/8/12/entrez PY - 2011/8/13/pubmed PY - 2011/12/13/medline SP - 3250 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 96 IS - 10 N2 - BACKGROUND: An association between vitamin D status and sarcopenia has not been shown in a community-dwelling cohort, despite the well-documented relationship between vitamin D status and falls. OBJECTIVE: Our objective was to investigate whether vitamin D level is associated with sarcopenia in older Koreans. DESIGN AND SETTING: The Fourth Korea National Health and Nutrition Examination Survey in the Korean population was conducted in 2009. PARTICIPANTS: Participants included 1380 men and 1789 women aged 50 yr or older. MEASUREMENTS: Serum 25-hydroxyvitamin D [25(OH)D] and PTH levels were measured. Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight that was less than 2 sd below the sex-specific mean for young adults. Obesity was defined as a body mass index (BMI) of 27.5 kg/m(2) or higher. RESULTS: 25(OH)D level correlated negatively with appendicular fat mass and positively with appendicular skeletal mass. The groups with sarcopenic obesity and sarcopenia only had lower 25(OH)D levels than did the nonsarcopenia groups. However, 25(OH)D levels did not differ between the sarcopenic obesity and sarcopenia groups. After adjustment for age, sex, BMI, and lifestyle factors, compared with those in the lowest quartile of 25(OH)D level, participants in the highest quartile had an odds ratio for sarcopenia of 0.47 (95% confidence interval = 0.30-0.73; P for trend = 0.001). There was no association between PTH and sarcopenia after adjustment of BMI. CONCLUSIONS: Vitamin D levels were significantly lower in subjects with sarcopenia than in those without, regardless of obesity. We found a strong inverse association between 25(OH)D level and sarcopenia in the older Korean population. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/21832109/Vitamin_D_deficiency_is_associated_with_sarcopenia_in_older_Koreans_regardless_of_obesity:_the_Fourth_Korea_National_Health_and_Nutrition_Examination_Surveys__KNHANES_IV__2009_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-1602 DB - PRIME DP - Unbound Medicine ER -
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