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Associated factors for REM sleep behavior disorder in Parkinson disease.
Neurology. 2011 Sep 13; 77(11):1048-54.Neur

Abstract

OBJECTIVE

To investigate the frequency, phenomenology, and associated risk factors of REM sleep behavior disorder (RBD) in Parkinson disease (PD).

METHODS

An unselected cohort of sleep-disturbed patients with PD (n=457) was investigated with video-supported polysomnography. We determined the frequency of RBD and analyzed the influence of age, clinical disease features, disease duration, cognitive and physical impairment, medication, comorbidity, and sleep architecture.

RESULTS

The overall frequency of RBD was 46%. According to our cohort and modified definition, there was no preferred PD subtype for RBD (p=0.142). There was no gender preference (p=0.770). RBD was associated with older age (p=0.000). Adjusted for age and gender, patients with PD and RBD had longer disease duration (p=0.024), higher Hoehn & Yahr stages (p=0.002), more falls (p=0.018), more fluctuations (p=0.005), more psychiatric comorbidity (p=0.026), and a higher dose of levodopa (p=0.002). The presence of RBD was related to slightly increased sleep efficiency (p=0.007), a higher amount of REM sleep (p=0.000), and more periodic leg movements during sleep (p=0.019).

CONCLUSION

RBD is a frequent and clinically relevant nocturnal disturbance for all stages of PD. It increases with age and disease duration and may contribute to the nocturnal problems of patients with PD and their bed partners.

Authors+Show Affiliations

Paracelsus-Elena-Klinik, Center of Parkinsonism and Movement Disorders, Klinikstr. 16, 34128 Kassel, Germany. friederike.sixel@pk-mx.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21832215

Citation

Sixel-Döring, Friederike, et al. "Associated Factors for REM Sleep Behavior Disorder in Parkinson Disease." Neurology, vol. 77, no. 11, 2011, pp. 1048-54.
Sixel-Döring F, Trautmann E, Mollenhauer B, et al. Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology. 2011;77(11):1048-54.
Sixel-Döring, F., Trautmann, E., Mollenhauer, B., & Trenkwalder, C. (2011). Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology, 77(11), 1048-54. https://doi.org/10.1212/WNL.0b013e31822e560e
Sixel-Döring F, et al. Associated Factors for REM Sleep Behavior Disorder in Parkinson Disease. Neurology. 2011 Sep 13;77(11):1048-54. PubMed PMID: 21832215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associated factors for REM sleep behavior disorder in Parkinson disease. AU - Sixel-Döring,Friederike, AU - Trautmann,Ellen, AU - Mollenhauer,Brit, AU - Trenkwalder,Claudia, Y1 - 2011/08/10/ PY - 2011/8/12/entrez PY - 2011/8/13/pubmed PY - 2011/11/4/medline SP - 1048 EP - 54 JF - Neurology JO - Neurology VL - 77 IS - 11 N2 - OBJECTIVE: To investigate the frequency, phenomenology, and associated risk factors of REM sleep behavior disorder (RBD) in Parkinson disease (PD). METHODS: An unselected cohort of sleep-disturbed patients with PD (n=457) was investigated with video-supported polysomnography. We determined the frequency of RBD and analyzed the influence of age, clinical disease features, disease duration, cognitive and physical impairment, medication, comorbidity, and sleep architecture. RESULTS: The overall frequency of RBD was 46%. According to our cohort and modified definition, there was no preferred PD subtype for RBD (p=0.142). There was no gender preference (p=0.770). RBD was associated with older age (p=0.000). Adjusted for age and gender, patients with PD and RBD had longer disease duration (p=0.024), higher Hoehn & Yahr stages (p=0.002), more falls (p=0.018), more fluctuations (p=0.005), more psychiatric comorbidity (p=0.026), and a higher dose of levodopa (p=0.002). The presence of RBD was related to slightly increased sleep efficiency (p=0.007), a higher amount of REM sleep (p=0.000), and more periodic leg movements during sleep (p=0.019). CONCLUSION: RBD is a frequent and clinically relevant nocturnal disturbance for all stages of PD. It increases with age and disease duration and may contribute to the nocturnal problems of patients with PD and their bed partners. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/21832215/Associated_factors_for_REM_sleep_behavior_disorder_in_Parkinson_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=21832215 DB - PRIME DP - Unbound Medicine ER -