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Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis?
Scand J Clin Lab Invest. 2011 Nov; 71(7):593-7.SJ

Abstract

OBJECTIVE

The aim of the present study was to investigate serum and bronchoalveolar lavage fluid (BALF) interleukin-18 (IL-18) levels in sarcoidosis and idiopathic pulmonary fibrosis (IPF) and to assess the clinical usefulness of IL-18 in these diseases.

METHODS

Serum and BALF levels of IL-18 were measured in 15 patients with sarcoidosis, 10 patients with IPF and 24 control subjects (8 with lung tumor, 6 with pulmonary tuberculosis and 10 healthy controls). Lymphocyte fractions (T, B and natural killer (NK) cells) in blood and BALF were analysed by flow cytometer.

RESULTS

The serum and BALF levels of IL-18 in patients with sarcoidosis were significantly higher (p < 0.05) than those in IPF subjects and control groups. The percentages of T, B and NK cells in blood and BALF did not differ among all groups, while the blood and BALF CD4/CD8 ratios in patients with sarcoidosis were significantly higher (p < 0.05) than those in the other groups. Among all subjects, the serum levels of IL-18 correlated positively with the CD4/CD8 ratios in BALF (r = 0.693, p < 0.001).

CONCLUSIONS

As to the levels of IL-18 in serum and BALF, there were differences between sarcoidosis and IPF indicating a different role of IL-18 in the pathogenesis of these diseases. Measurement of circulating IL-18 might have a potential of clinical utility in the differential diagnosis of sarcoidosis versus IPF.

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Authors+Show Affiliations

Liu DH
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cui W
No affiliation info available
Chen Q
No affiliation info available
Huang CM
No affiliation info available

MeSH

AdultBronchoalveolar Lavage FluidCD4-CD8 RatioCase-Control StudiesChinaDiagnosis, DifferentialEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansIdiopathic Pulmonary FibrosisInterleukin-18LungLung NeoplasmsLymphocyte CountMaleMiddle AgedMycobacterium tuberculosisSarcoidosis, PulmonaryTuberculosis, Pulmonary

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21834618

Citation

Liu, Ding-Hua, et al. "Can Circulating Interleukin-18 Differentiate Between Sarcoidosis and Idiopathic Pulmonary Fibrosis?" Scandinavian Journal of Clinical and Laboratory Investigation, vol. 71, no. 7, 2011, pp. 593-7.
Liu DH, Cui W, Chen Q, et al. Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? Scand J Clin Lab Invest. 2011;71(7):593-7.
Liu, D. H., Cui, W., Chen, Q., & Huang, C. M. (2011). Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? Scandinavian Journal of Clinical and Laboratory Investigation, 71(7), 593-7. https://doi.org/10.3109/00365513.2011.597871
Liu DH, et al. Can Circulating Interleukin-18 Differentiate Between Sarcoidosis and Idiopathic Pulmonary Fibrosis. Scand J Clin Lab Invest. 2011;71(7):593-7. PubMed PMID: 21834618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? AU - Liu,Ding-Hua, AU - Cui,Wei, AU - Chen,Qian, AU - Huang,Chun-Mei, Y1 - 2011/08/11/ PY - 2011/8/13/entrez PY - 2011/8/13/pubmed PY - 2012/2/9/medline SP - 593 EP - 7 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 71 IS - 7 N2 - OBJECTIVE: The aim of the present study was to investigate serum and bronchoalveolar lavage fluid (BALF) interleukin-18 (IL-18) levels in sarcoidosis and idiopathic pulmonary fibrosis (IPF) and to assess the clinical usefulness of IL-18 in these diseases. METHODS: Serum and BALF levels of IL-18 were measured in 15 patients with sarcoidosis, 10 patients with IPF and 24 control subjects (8 with lung tumor, 6 with pulmonary tuberculosis and 10 healthy controls). Lymphocyte fractions (T, B and natural killer (NK) cells) in blood and BALF were analysed by flow cytometer. RESULTS: The serum and BALF levels of IL-18 in patients with sarcoidosis were significantly higher (p < 0.05) than those in IPF subjects and control groups. The percentages of T, B and NK cells in blood and BALF did not differ among all groups, while the blood and BALF CD4/CD8 ratios in patients with sarcoidosis were significantly higher (p < 0.05) than those in the other groups. Among all subjects, the serum levels of IL-18 correlated positively with the CD4/CD8 ratios in BALF (r = 0.693, p < 0.001). CONCLUSIONS: As to the levels of IL-18 in serum and BALF, there were differences between sarcoidosis and IPF indicating a different role of IL-18 in the pathogenesis of these diseases. Measurement of circulating IL-18 might have a potential of clinical utility in the differential diagnosis of sarcoidosis versus IPF. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/21834618/Can_circulating_interleukin_18_differentiate_between_sarcoidosis_and_idiopathic_pulmonary_fibrosis L2 - https://www.tandfonline.com/doi/full/10.3109/00365513.2011.597871 DB - PRIME DP - Unbound Medicine ER -
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