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Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis?
Scand J Clin Lab Invest. 2011 Nov; 71(7):593-7.SJ

Abstract

OBJECTIVE

The aim of the present study was to investigate serum and bronchoalveolar lavage fluid (BALF) interleukin-18 (IL-18) levels in sarcoidosis and idiopathic pulmonary fibrosis (IPF) and to assess the clinical usefulness of IL-18 in these diseases.

METHODS

Serum and BALF levels of IL-18 were measured in 15 patients with sarcoidosis, 10 patients with IPF and 24 control subjects (8 with lung tumor, 6 with pulmonary tuberculosis and 10 healthy controls). Lymphocyte fractions (T, B and natural killer (NK) cells) in blood and BALF were analysed by flow cytometer.

RESULTS

The serum and BALF levels of IL-18 in patients with sarcoidosis were significantly higher (p < 0.05) than those in IPF subjects and control groups. The percentages of T, B and NK cells in blood and BALF did not differ among all groups, while the blood and BALF CD4/CD8 ratios in patients with sarcoidosis were significantly higher (p < 0.05) than those in the other groups. Among all subjects, the serum levels of IL-18 correlated positively with the CD4/CD8 ratios in BALF (r = 0.693, p < 0.001).

CONCLUSIONS

As to the levels of IL-18 in serum and BALF, there were differences between sarcoidosis and IPF indicating a different role of IL-18 in the pathogenesis of these diseases. Measurement of circulating IL-18 might have a potential of clinical utility in the differential diagnosis of sarcoidosis versus IPF.

Authors+Show Affiliations

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21834618

Citation

Liu, Ding-Hua, et al. "Can Circulating Interleukin-18 Differentiate Between Sarcoidosis and Idiopathic Pulmonary Fibrosis?" Scandinavian Journal of Clinical and Laboratory Investigation, vol. 71, no. 7, 2011, pp. 593-7.
Liu DH, Cui W, Chen Q, et al. Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? Scand J Clin Lab Invest. 2011;71(7):593-7.
Liu, D. H., Cui, W., Chen, Q., & Huang, C. M. (2011). Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? Scandinavian Journal of Clinical and Laboratory Investigation, 71(7), 593-7. https://doi.org/10.3109/00365513.2011.597871
Liu DH, et al. Can Circulating Interleukin-18 Differentiate Between Sarcoidosis and Idiopathic Pulmonary Fibrosis. Scand J Clin Lab Invest. 2011;71(7):593-7. PubMed PMID: 21834618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? AU - Liu,Ding-Hua, AU - Cui,Wei, AU - Chen,Qian, AU - Huang,Chun-Mei, Y1 - 2011/08/11/ PY - 2011/8/13/entrez PY - 2011/8/13/pubmed PY - 2012/2/9/medline SP - 593 EP - 7 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 71 IS - 7 N2 - OBJECTIVE: The aim of the present study was to investigate serum and bronchoalveolar lavage fluid (BALF) interleukin-18 (IL-18) levels in sarcoidosis and idiopathic pulmonary fibrosis (IPF) and to assess the clinical usefulness of IL-18 in these diseases. METHODS: Serum and BALF levels of IL-18 were measured in 15 patients with sarcoidosis, 10 patients with IPF and 24 control subjects (8 with lung tumor, 6 with pulmonary tuberculosis and 10 healthy controls). Lymphocyte fractions (T, B and natural killer (NK) cells) in blood and BALF were analysed by flow cytometer. RESULTS: The serum and BALF levels of IL-18 in patients with sarcoidosis were significantly higher (p < 0.05) than those in IPF subjects and control groups. The percentages of T, B and NK cells in blood and BALF did not differ among all groups, while the blood and BALF CD4/CD8 ratios in patients with sarcoidosis were significantly higher (p < 0.05) than those in the other groups. Among all subjects, the serum levels of IL-18 correlated positively with the CD4/CD8 ratios in BALF (r = 0.693, p < 0.001). CONCLUSIONS: As to the levels of IL-18 in serum and BALF, there were differences between sarcoidosis and IPF indicating a different role of IL-18 in the pathogenesis of these diseases. Measurement of circulating IL-18 might have a potential of clinical utility in the differential diagnosis of sarcoidosis versus IPF. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/21834618/Can_circulating_interleukin_18_differentiate_between_sarcoidosis_and_idiopathic_pulmonary_fibrosis L2 - http://www.tandfonline.com/doi/full/10.3109/00365513.2011.597871 DB - PRIME DP - Unbound Medicine ER -