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Altered macrophage function is associated with severe Burkholderia pseudomallei infection in a murine model of type 2 diabetes.
Microbes Infect. 2011 Dec; 13(14-15):1177-84.MI

Abstract

This study used a murine model of type 2 diabetes (BKS.Cg-Dock7(m) +/+Lepr(db)/J mice) to investigate the inflammatory and cellular mechanisms predisposing to Burkholderia pseudomallei infection and co-morbid diabetes. Homozygous db/db (diabetic) mice developed extreme obesity, dyslipidaemia and glucose intolerance leading to hyperglycaemia and overt type 2 diabetes. Compared to their heterozygous db/+ (non-diabetic) littermates, diabetic mice rapidly succumbed to subcutaneous B. pseudomallei infection, paralleled by severe hypoglycaemia and increased expression of the proinflammatory cytokines, tumour necrosis factor (TNF)-α and interleukin (IL)-1β, in the spleen, despite comparable bacterial loads in the spleen of non-diabetic mice. Neutrophil oxidative burst and dendritic cell uptake and killing of B. pseudomallei were similar between diabetic and non-diabetic mice. Compared to peritoneal macrophages from non-diabetic mice, macrophages from diabetic mice were unable to contain and kill B. pseudomallei. Functional differences between macrophages of diabetic and non-diabetic mice toward B. pseudomallei may contribute to rapid dissemination and more severe disease progression in hosts with co-morbid type 2 diabetes.

Authors+Show Affiliations

Microbiology and Immunology, School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Queensland 4811, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21835260

Citation

Hodgson, Kelly A., et al. "Altered Macrophage Function Is Associated With Severe Burkholderia Pseudomallei Infection in a Murine Model of Type 2 Diabetes." Microbes and Infection, vol. 13, no. 14-15, 2011, pp. 1177-84.
Hodgson KA, Morris JL, Feterl ML, et al. Altered macrophage function is associated with severe Burkholderia pseudomallei infection in a murine model of type 2 diabetes. Microbes Infect. 2011;13(14-15):1177-84.
Hodgson, K. A., Morris, J. L., Feterl, M. L., Govan, B. L., & Ketheesan, N. (2011). Altered macrophage function is associated with severe Burkholderia pseudomallei infection in a murine model of type 2 diabetes. Microbes and Infection, 13(14-15), 1177-84. https://doi.org/10.1016/j.micinf.2011.07.008
Hodgson KA, et al. Altered Macrophage Function Is Associated With Severe Burkholderia Pseudomallei Infection in a Murine Model of Type 2 Diabetes. Microbes Infect. 2011;13(14-15):1177-84. PubMed PMID: 21835260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered macrophage function is associated with severe Burkholderia pseudomallei infection in a murine model of type 2 diabetes. AU - Hodgson,Kelly A, AU - Morris,Jodie L, AU - Feterl,Marshall L, AU - Govan,Brenda L, AU - Ketheesan,Natkunam, Y1 - 2011/07/28/ PY - 2010/07/25/received PY - 2011/07/13/revised PY - 2011/07/21/accepted PY - 2011/8/13/entrez PY - 2011/8/13/pubmed PY - 2012/4/3/medline SP - 1177 EP - 84 JF - Microbes and infection JO - Microbes Infect VL - 13 IS - 14-15 N2 - This study used a murine model of type 2 diabetes (BKS.Cg-Dock7(m) +/+Lepr(db)/J mice) to investigate the inflammatory and cellular mechanisms predisposing to Burkholderia pseudomallei infection and co-morbid diabetes. Homozygous db/db (diabetic) mice developed extreme obesity, dyslipidaemia and glucose intolerance leading to hyperglycaemia and overt type 2 diabetes. Compared to their heterozygous db/+ (non-diabetic) littermates, diabetic mice rapidly succumbed to subcutaneous B. pseudomallei infection, paralleled by severe hypoglycaemia and increased expression of the proinflammatory cytokines, tumour necrosis factor (TNF)-α and interleukin (IL)-1β, in the spleen, despite comparable bacterial loads in the spleen of non-diabetic mice. Neutrophil oxidative burst and dendritic cell uptake and killing of B. pseudomallei were similar between diabetic and non-diabetic mice. Compared to peritoneal macrophages from non-diabetic mice, macrophages from diabetic mice were unable to contain and kill B. pseudomallei. Functional differences between macrophages of diabetic and non-diabetic mice toward B. pseudomallei may contribute to rapid dissemination and more severe disease progression in hosts with co-morbid type 2 diabetes. SN - 1769-714X UR - https://www.unboundmedicine.com/medline/citation/21835260/Altered_macrophage_function_is_associated_with_severe_Burkholderia_pseudomallei_infection_in_a_murine_model_of_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1286-4579(11)00195-X DB - PRIME DP - Unbound Medicine ER -