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Vegetarianism, vitamin B12 status, and insulin resistance in a group of predominantly overweight/obese South Asian women.
Nutrition. 2012 Jan; 28(1):20-4.N

Abstract

OBJECTIVES

Asian Indians are an at-risk group for vitamin B12 deficiency (because of vegetarianism) and insulin resistance (IR). Vegetarianism and consequent vitamin B12 deficiency may be associated with IR. This study aimed to describe the vitamin B12 status of predominantly overweight/obese women of South Asian origin living in Auckland and to correlate serum vitamin B12 and vegetarian status with IR as part of the larger Surya Study looking at health and lifestyle in this population.

METHODS

This was a cross-sectional study of 135 women at least 20 y of age who were not taking vitamin B supplements or medications that could affect vitamin B12 concentrations (serum vitamin B12 < 800 pmol/L). Data collection included serum vitamin B12, serum folate, measurements of IR (HOMA2-IR), and anthropometry. Vegetarian status was established for 124 subjects (90 non-vegetarians, 34 vegetarians).

RESULTS

Mean serum vitamin B12 was 227 pmol/L (95% confidence interval 210-245), serum folate was 19.1 nmol/L (18.0-20.2), and HOMA2-IR was 1.24 (1.13-1.36). Non-vegetarians had higher serum vitamin B12 levels (257 pmol/L, 235-281) than vegetarians (181 pmol/L, 159-207), P < 0.001. Vitamin B12 deficiency (<150 pmol/L) in vegetarians was 24% versus 9% in non-vegetarians. Non-vegetarians had increased body mass index (25.9 kg/m², 25.0-26.9, versus 23.9 kg/m², 22.6-25.3), waist circumference (81 ± 10.1 versus 75.8 ± 9.88 cm), and HOMA2-IR levels (1.30, 1.17-1.46, versus 1.00, 0.83-1.22). No correlation was found between serum vitamin B12 and HOMA2-IR. A significant positive correlation between non-vegetarian status and IR disappeared after controlling for body mass index.

CONCLUSIONS

This study population has a low serum vitamin B12 status, especially if vegetarian. The high rates of observed obesity may have overshadowed any other contributing factor to IR.

Authors+Show Affiliations

Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand. C.Gammon@massey.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21835592

Citation

Gammon, Cheryl S., et al. "Vegetarianism, Vitamin B12 Status, and Insulin Resistance in a Group of Predominantly Overweight/obese South Asian Women." Nutrition (Burbank, Los Angeles County, Calif.), vol. 28, no. 1, 2012, pp. 20-4.
Gammon CS, von Hurst PR, Coad J, et al. Vegetarianism, vitamin B12 status, and insulin resistance in a group of predominantly overweight/obese South Asian women. Nutrition. 2012;28(1):20-4.
Gammon, C. S., von Hurst, P. R., Coad, J., Kruger, R., & Stonehouse, W. (2012). Vegetarianism, vitamin B12 status, and insulin resistance in a group of predominantly overweight/obese South Asian women. Nutrition (Burbank, Los Angeles County, Calif.), 28(1), 20-4. https://doi.org/10.1016/j.nut.2011.05.006
Gammon CS, et al. Vegetarianism, Vitamin B12 Status, and Insulin Resistance in a Group of Predominantly Overweight/obese South Asian Women. Nutrition. 2012;28(1):20-4. PubMed PMID: 21835592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetarianism, vitamin B12 status, and insulin resistance in a group of predominantly overweight/obese South Asian women. AU - Gammon,Cheryl S, AU - von Hurst,Pamela R, AU - Coad,Jane, AU - Kruger,Rozanne, AU - Stonehouse,Welma, Y1 - 2011/08/11/ PY - 2010/10/04/received PY - 2011/02/23/revised PY - 2011/05/01/accepted PY - 2011/8/13/entrez PY - 2011/8/13/pubmed PY - 2012/4/17/medline SP - 20 EP - 4 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 28 IS - 1 N2 - OBJECTIVES: Asian Indians are an at-risk group for vitamin B12 deficiency (because of vegetarianism) and insulin resistance (IR). Vegetarianism and consequent vitamin B12 deficiency may be associated with IR. This study aimed to describe the vitamin B12 status of predominantly overweight/obese women of South Asian origin living in Auckland and to correlate serum vitamin B12 and vegetarian status with IR as part of the larger Surya Study looking at health and lifestyle in this population. METHODS: This was a cross-sectional study of 135 women at least 20 y of age who were not taking vitamin B supplements or medications that could affect vitamin B12 concentrations (serum vitamin B12 < 800 pmol/L). Data collection included serum vitamin B12, serum folate, measurements of IR (HOMA2-IR), and anthropometry. Vegetarian status was established for 124 subjects (90 non-vegetarians, 34 vegetarians). RESULTS: Mean serum vitamin B12 was 227 pmol/L (95% confidence interval 210-245), serum folate was 19.1 nmol/L (18.0-20.2), and HOMA2-IR was 1.24 (1.13-1.36). Non-vegetarians had higher serum vitamin B12 levels (257 pmol/L, 235-281) than vegetarians (181 pmol/L, 159-207), P < 0.001. Vitamin B12 deficiency (<150 pmol/L) in vegetarians was 24% versus 9% in non-vegetarians. Non-vegetarians had increased body mass index (25.9 kg/m², 25.0-26.9, versus 23.9 kg/m², 22.6-25.3), waist circumference (81 ± 10.1 versus 75.8 ± 9.88 cm), and HOMA2-IR levels (1.30, 1.17-1.46, versus 1.00, 0.83-1.22). No correlation was found between serum vitamin B12 and HOMA2-IR. A significant positive correlation between non-vegetarian status and IR disappeared after controlling for body mass index. CONCLUSIONS: This study population has a low serum vitamin B12 status, especially if vegetarian. The high rates of observed obesity may have overshadowed any other contributing factor to IR. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/21835592/Vegetarianism_vitamin_B12_status_and_insulin_resistance_in_a_group_of_predominantly_overweight/obese_South_Asian_women_ DB - PRIME DP - Unbound Medicine ER -