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Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus.
Growth Horm IGF Res. 2011 Oct; 21(5):268-71.GH

Abstract

BACKGROUND

Although insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone-sulfate (DHEA-S) are involved in age-related diseases such as cardiovascular disease and diabetes mellitus, the association of these hormones with serum adiponectin level is still unclear.

OBJECTIVE AND METHODS

To investigate the association between serum IGF-I and DHEA-S versus adiponectin, we conducted a cross-sectional study of 348 Japanese men with type 2 diabetes mellitus and examined their relationships. Serum total adiponectin level was measured by an ELISA kit.

RESULTS

Simple correlation analysis showed that patients' age and duration of diabetes were negatively correlated with IGF-I and DHEA-S (p<0.01) and positively with adiponectin (p<0.01), while body mass index (BMI) was positively correlated with IGF-I and DHEA-S (p<0.001) and negatively with adiponectin (p<0.001). IGF-I was negatively correlated with adiponectin (r=-0.25, p<0.001) and DHEA-S was negatively correlated with adiponectin and HbA1c (r=-0.17, p=0.003 and r=-0.12, p=0.027, respectively). In multiple regression analysis adjusted for age, duration of diabetes, BMI, and serum creatinine, HbA1c was negatively associated with IGF-I and DHEA-S (β=-0.12, p=0.036 and β=-0.22, p<0.001, respectively). Adiponectin was negatively associated with IGF-I (β=-0.15, p=0.013), but not DHEA-S. Moreover, this association was still significant after additional adjustment for HbA1c (β=-0.18, p=0.005).

CONCLUSIONS

Present cross-sectional study for the first time showed a negative association of serum IGF-I with serum adiponectin in Japanese men with type 2 diabetes independent of age, duration of diabetes, BMI, renal function, and HbA1c.

Authors+Show Affiliations

Department of Internal Medicine, Shimane University, Japan. ippei.k@med.shimane-u.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21839662

Citation

Kanazawa, Ippei, et al. "Serum Insulin-like Growth factor-I Is Negatively Associated With Serum Adiponectin in Type 2 Diabetes Mellitus." Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, vol. 21, no. 5, 2011, pp. 268-71.
Kanazawa I, Yamaguchi T, Sugimoto T. Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus. Growth Horm IGF Res. 2011;21(5):268-71.
Kanazawa, I., Yamaguchi, T., & Sugimoto, T. (2011). Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus. Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 21(5), 268-71. https://doi.org/10.1016/j.ghir.2011.07.004
Kanazawa I, Yamaguchi T, Sugimoto T. Serum Insulin-like Growth factor-I Is Negatively Associated With Serum Adiponectin in Type 2 Diabetes Mellitus. Growth Horm IGF Res. 2011;21(5):268-71. PubMed PMID: 21839662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus. AU - Kanazawa,Ippei, AU - Yamaguchi,Toru, AU - Sugimoto,Toshitsugu, Y1 - 2011/08/11/ PY - 2011/03/11/received PY - 2011/05/26/revised PY - 2011/07/18/accepted PY - 2011/8/16/entrez PY - 2011/8/16/pubmed PY - 2012/1/27/medline SP - 268 EP - 71 JF - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JO - Growth Horm IGF Res VL - 21 IS - 5 N2 - BACKGROUND: Although insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone-sulfate (DHEA-S) are involved in age-related diseases such as cardiovascular disease and diabetes mellitus, the association of these hormones with serum adiponectin level is still unclear. OBJECTIVE AND METHODS: To investigate the association between serum IGF-I and DHEA-S versus adiponectin, we conducted a cross-sectional study of 348 Japanese men with type 2 diabetes mellitus and examined their relationships. Serum total adiponectin level was measured by an ELISA kit. RESULTS: Simple correlation analysis showed that patients' age and duration of diabetes were negatively correlated with IGF-I and DHEA-S (p<0.01) and positively with adiponectin (p<0.01), while body mass index (BMI) was positively correlated with IGF-I and DHEA-S (p<0.001) and negatively with adiponectin (p<0.001). IGF-I was negatively correlated with adiponectin (r=-0.25, p<0.001) and DHEA-S was negatively correlated with adiponectin and HbA1c (r=-0.17, p=0.003 and r=-0.12, p=0.027, respectively). In multiple regression analysis adjusted for age, duration of diabetes, BMI, and serum creatinine, HbA1c was negatively associated with IGF-I and DHEA-S (β=-0.12, p=0.036 and β=-0.22, p<0.001, respectively). Adiponectin was negatively associated with IGF-I (β=-0.15, p=0.013), but not DHEA-S. Moreover, this association was still significant after additional adjustment for HbA1c (β=-0.18, p=0.005). CONCLUSIONS: Present cross-sectional study for the first time showed a negative association of serum IGF-I with serum adiponectin in Japanese men with type 2 diabetes independent of age, duration of diabetes, BMI, renal function, and HbA1c. SN - 1532-2238 UR - https://www.unboundmedicine.com/medline/citation/21839662/Serum_insulin_like_growth_factor_I_is_negatively_associated_with_serum_adiponectin_in_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-6374(11)00079-7 DB - PRIME DP - Unbound Medicine ER -