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Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity.
Nutr Res. 2011 Jul; 31(7):555-62.NR

Abstract

Oxidative stress is involved in the development and progression of diabetic nephropathy (DN). Because Trigonella foenum graecum has been reported to have antidiabetic and antioxidative effects, we hypothesized that T foenum graecum seed aqueous extract (TE) restores the kidney function of diabetic rats via its antioxidant activity. Rats were fed diets enriched with sucrose (50%, wt/wt), lard (30%, wt/wt), and cholesterol (2.5%, wt/wt) for 8 weeks to induce insulin resistance. After a DN model was induced by streptozotocin, the rats were administered a low (440 mg/kg), medium (870 mg/kg), or high (1740 mg/kg) dose of TE by oral intragastric intubation for 6 weeks. In TE-treated DN rats, blood glucose, kidney/body weight ratio, serum creatinine, blood urea nitrogen, 24-hour content of urinary protein, and creatinine clearance were significantly decreased compared with nontreated DN rats. Diabetic rats showed decreased activities of superoxide dismutase and catalase, increased concentrations of malondialdehyde in the serum and kidney, and increased levels of 8-hydroxy-2'-deoxyguanosine in urine and renal cortex DNA. Treatment with TE restored the altered parameters in a dose-dependent manner. Furthermore, all of the ultramorphologic abnormalities in the kidney of diabetic rats, including the uneven thickening of the glomerular base membrane, were markedly ameliorated by TE treatment. We conclude that TE confers protection against functional and morphologic injuries in the kidneys of diabetic rats by increasing activities of antioxidants and inhibiting accumulation of oxidized DNA in the kidney, suggesting a potential drug for the prevention and therapy of DN.

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Authors+Show Affiliations

Xue W
Department of Public Health, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, PR China. xwl0908@163.com
Lei J
No affiliation info available
Li X
No affiliation info available
Zhang R
No affiliation info available

MeSH

8-Hydroxy-2'-DeoxyguanosineAnimalsAntioxidantsBiomarkersBlood GlucoseBlood Urea NitrogenBody WeightCatalaseCreatinineDNADeoxyguanosineDiabetes Mellitus, ExperimentalDiabetic NephropathiesDietDose-Response Relationship, DrugHypoglycemic AgentsInsulin ResistanceKidneyMaleMalondialdehydeOrgan SizeOxidative StressPhytotherapyPlant ExtractsRatsRats, Sprague-DawleySeedsSuperoxide DismutaseTrigonella

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21840472

Citation

Xue, Wanli, et al. "Trigonella Foenum Graecum Seed Extract Protects Kidney Function and Morphology in Diabetic Rats Via Its Antioxidant Activity." Nutrition Research (New York, N.Y.), vol. 31, no. 7, 2011, pp. 555-62.
Xue W, Lei J, Li X, et al. Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity. Nutr Res. 2011;31(7):555-62.
Xue, W., Lei, J., Li, X., & Zhang, R. (2011). Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity. Nutrition Research (New York, N.Y.), 31(7), 555-62. https://doi.org/10.1016/j.nutres.2011.05.010
Xue W, et al. Trigonella Foenum Graecum Seed Extract Protects Kidney Function and Morphology in Diabetic Rats Via Its Antioxidant Activity. Nutr Res. 2011;31(7):555-62. PubMed PMID: 21840472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity. AU - Xue,Wanli, AU - Lei,Jing, AU - Li,Xuanshe, AU - Zhang,Ruijuan, PY - 2011/02/08/received PY - 2011/04/29/revised PY - 2011/05/31/accepted PY - 2011/8/16/entrez PY - 2011/8/16/pubmed PY - 2012/1/4/medline SP - 555 EP - 62 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 31 IS - 7 N2 - Oxidative stress is involved in the development and progression of diabetic nephropathy (DN). Because Trigonella foenum graecum has been reported to have antidiabetic and antioxidative effects, we hypothesized that T foenum graecum seed aqueous extract (TE) restores the kidney function of diabetic rats via its antioxidant activity. Rats were fed diets enriched with sucrose (50%, wt/wt), lard (30%, wt/wt), and cholesterol (2.5%, wt/wt) for 8 weeks to induce insulin resistance. After a DN model was induced by streptozotocin, the rats were administered a low (440 mg/kg), medium (870 mg/kg), or high (1740 mg/kg) dose of TE by oral intragastric intubation for 6 weeks. In TE-treated DN rats, blood glucose, kidney/body weight ratio, serum creatinine, blood urea nitrogen, 24-hour content of urinary protein, and creatinine clearance were significantly decreased compared with nontreated DN rats. Diabetic rats showed decreased activities of superoxide dismutase and catalase, increased concentrations of malondialdehyde in the serum and kidney, and increased levels of 8-hydroxy-2'-deoxyguanosine in urine and renal cortex DNA. Treatment with TE restored the altered parameters in a dose-dependent manner. Furthermore, all of the ultramorphologic abnormalities in the kidney of diabetic rats, including the uneven thickening of the glomerular base membrane, were markedly ameliorated by TE treatment. We conclude that TE confers protection against functional and morphologic injuries in the kidneys of diabetic rats by increasing activities of antioxidants and inhibiting accumulation of oxidized DNA in the kidney, suggesting a potential drug for the prevention and therapy of DN. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/21840472/Trigonella_foenum_graecum_seed_extract_protects_kidney_function_and_morphology_in_diabetic_rats_via_its_antioxidant_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(11)00113-8 DB - PRIME DP - Unbound Medicine ER -