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Risk of endometriosis in 11,000 women with celiac disease.
Hum Reprod 2011; 26(10):2896-901HR

Abstract

BACKGROUND

Endometriosis is a common cause of infertility. Whereas celiac disease (CD) is present in ~1% of individuals in Western Europe, the prevalence in women undergoing investigation for infertility is often >2%. Still, the relationship between CD and endometriosis is unclear.

METHODS

We identified 11 097 women with CD (Marsh 3: villous atrophy) through biopsy data from all 28 pathology departments in Sweden. Biopsies had been performed between 1973 and 2008. Data on inpatient and outpatient diagnoses of endometriosis were retrieved from the National Patient Register. We then used the Cox regression to estimate the hazard ratios (HRs) for endometriosis in women with CD to compare with those in 54 992 age-matched control women.

RESULTS

During the follow-up, 118 individuals with CD and 399 matched controls developed endometriosis. Hence, patients with CD were at increased risk of subsequent endometriosis [HR = 1.39; 95% confidence interval (CI) = 1.14-1.70]. The absolute risk of endometriosis in patients with CD was 112/100,000 person-years with an excess risk of 31/100,000. Risk estimates were highest in the first year after diagnosis (HR = 1.49; 95% CI = 0.83-2.67) and gradually decreased (>5 years after CD diagnosis, HR = 1.33; 95% CI = 1.00-1.79).

CONCLUSION

Endometriosis seems to be associated with prior CD. Potential explanations include shared etiological factors and CD-mediated inflammation.

Authors+Show Affiliations

Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, 171 76 Stockholm, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21840904

Citation

Stephansson, Olof, et al. "Risk of Endometriosis in 11,000 Women With Celiac Disease." Human Reproduction (Oxford, England), vol. 26, no. 10, 2011, pp. 2896-901.
Stephansson O, Falconer H, Ludvigsson JF. Risk of endometriosis in 11,000 women with celiac disease. Hum Reprod. 2011;26(10):2896-901.
Stephansson, O., Falconer, H., & Ludvigsson, J. F. (2011). Risk of endometriosis in 11,000 women with celiac disease. Human Reproduction (Oxford, England), 26(10), pp. 2896-901. doi:10.1093/humrep/der263.
Stephansson O, Falconer H, Ludvigsson JF. Risk of Endometriosis in 11,000 Women With Celiac Disease. Hum Reprod. 2011;26(10):2896-901. PubMed PMID: 21840904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of endometriosis in 11,000 women with celiac disease. AU - Stephansson,Olof, AU - Falconer,Henrik, AU - Ludvigsson,Jonas F, Y1 - 2011/08/12/ PY - 2011/8/16/entrez PY - 2011/8/16/pubmed PY - 2012/3/27/medline SP - 2896 EP - 901 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 26 IS - 10 N2 - BACKGROUND: Endometriosis is a common cause of infertility. Whereas celiac disease (CD) is present in ~1% of individuals in Western Europe, the prevalence in women undergoing investigation for infertility is often >2%. Still, the relationship between CD and endometriosis is unclear. METHODS: We identified 11 097 women with CD (Marsh 3: villous atrophy) through biopsy data from all 28 pathology departments in Sweden. Biopsies had been performed between 1973 and 2008. Data on inpatient and outpatient diagnoses of endometriosis were retrieved from the National Patient Register. We then used the Cox regression to estimate the hazard ratios (HRs) for endometriosis in women with CD to compare with those in 54 992 age-matched control women. RESULTS: During the follow-up, 118 individuals with CD and 399 matched controls developed endometriosis. Hence, patients with CD were at increased risk of subsequent endometriosis [HR = 1.39; 95% confidence interval (CI) = 1.14-1.70]. The absolute risk of endometriosis in patients with CD was 112/100,000 person-years with an excess risk of 31/100,000. Risk estimates were highest in the first year after diagnosis (HR = 1.49; 95% CI = 0.83-2.67) and gradually decreased (>5 years after CD diagnosis, HR = 1.33; 95% CI = 1.00-1.79). CONCLUSION: Endometriosis seems to be associated with prior CD. Potential explanations include shared etiological factors and CD-mediated inflammation. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/21840904/Risk_of_endometriosis_in_11000_women_with_celiac_disease_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/der263 DB - PRIME DP - Unbound Medicine ER -