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Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools.
Clin Sci (Lond) 2011; 121(11):459-88CS

Abstract

H2S (hydrogen sulfide) is a well known and pungent gas recently discovered to be synthesized enzymatically in mammalian and human tissues. In a relatively short period of time, H2S has attracted substantial interest as an endogenous gaseous mediator and potential target for pharmacological manipulation. Studies in animals and humans have shown H2S to be involved in diverse physiological and pathophysiological processes, such as learning and memory, neurodegeneration, regulation of inflammation and blood pressure, and metabolism. However, research is limited by the lack of specific analytical and pharmacological tools which has led to considerable controversy in the literature. Commonly used inhibitors of endogenous H2S synthesis have been well known for decades to interact with other metabolic pathways or even generate NO (nitric oxide). Similarly, commonly used H2S donors release H2S far too quickly to be physiologically relevant, but may have therapeutic applications. In the present review, we discuss the enzymatic synthesis of H2S and its emerging importance as a mediator in physiology and pathology. We also critically discuss the suitability of proposed 'biomarkers' of H2S synthesis and metabolism, and highlight the complexities of the currently used pharmacological H2S 'donor' molecules and 'specific' H2S synthesis inhibitors in their application to studying the role of H2S in human disease.

Authors+Show Affiliations

Peninsula Medical School, University of Exeter, St Luke's Campus, Magdalen Road, Exeter EX1 2LU, UK. m.whiteman@exeter.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21843150

Citation

Whiteman, Matthew, et al. "Emerging Role of Hydrogen Sulfide in Health and Disease: Critical Appraisal of Biomarkers and Pharmacological Tools." Clinical Science (London, England : 1979), vol. 121, no. 11, 2011, pp. 459-88.
Whiteman M, Le Trionnaire S, Chopra M, et al. Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clin Sci. 2011;121(11):459-88.
Whiteman, M., Le Trionnaire, S., Chopra, M., Fox, B., & Whatmore, J. (2011). Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clinical Science (London, England : 1979), 121(11), pp. 459-88. doi:10.1042/CS20110267.
Whiteman M, et al. Emerging Role of Hydrogen Sulfide in Health and Disease: Critical Appraisal of Biomarkers and Pharmacological Tools. Clin Sci. 2011;121(11):459-88. PubMed PMID: 21843150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. AU - Whiteman,Matthew, AU - Le Trionnaire,Sophie, AU - Chopra,Mohit, AU - Fox,Bridget, AU - Whatmore,Jacqueline, PY - 2011/8/17/entrez PY - 2011/8/17/pubmed PY - 2011/10/18/medline SP - 459 EP - 88 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 121 IS - 11 N2 - H2S (hydrogen sulfide) is a well known and pungent gas recently discovered to be synthesized enzymatically in mammalian and human tissues. In a relatively short period of time, H2S has attracted substantial interest as an endogenous gaseous mediator and potential target for pharmacological manipulation. Studies in animals and humans have shown H2S to be involved in diverse physiological and pathophysiological processes, such as learning and memory, neurodegeneration, regulation of inflammation and blood pressure, and metabolism. However, research is limited by the lack of specific analytical and pharmacological tools which has led to considerable controversy in the literature. Commonly used inhibitors of endogenous H2S synthesis have been well known for decades to interact with other metabolic pathways or even generate NO (nitric oxide). Similarly, commonly used H2S donors release H2S far too quickly to be physiologically relevant, but may have therapeutic applications. In the present review, we discuss the enzymatic synthesis of H2S and its emerging importance as a mediator in physiology and pathology. We also critically discuss the suitability of proposed 'biomarkers' of H2S synthesis and metabolism, and highlight the complexities of the currently used pharmacological H2S 'donor' molecules and 'specific' H2S synthesis inhibitors in their application to studying the role of H2S in human disease. SN - 1470-8736 UR - https://www.unboundmedicine.com/medline/citation/21843150/Emerging_role_of_hydrogen_sulfide_in_health_and_disease:_critical_appraisal_of_biomarkers_and_pharmacological_tools_ L2 - http://clinsci.org/cgi/pmidlookup?view=long&pmid=21843150 DB - PRIME DP - Unbound Medicine ER -