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Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic coenzyme Q10 pretreatment.
Toxicol Appl Pharmacol. 2011 Oct 01; 256(1):73-82.TA

Abstract

Numerous epidemiological studies have shown an association between pesticide exposure and increased risk of developing Parkinson's diseases. Oxidative stress generated as a result of mitochondrial dysfunction has been implicated as an important factor in the etiology of Parkinson's disease. Previously, we reported that chronic dichlorvos exposure causes mitochondrial impairments and nigrostriatal neuronal death in rats. The present study was designed to test whether Coenzyme Q(10) (CoQ(10)) administration has any neuroprotective effect against dichlorvos mediated nigrostriatal neuronal death, α-synuclein aggregation, and motor dysfunction. Male albino rats were administered dichlorvos by subcutaneous injection at a dose of 2.5 mg/kg body weight over a period of 12 weeks. Results obtained there after showed that dichlorvos exposure leads to enhanced mitochondrial ROS production, α-synuclein aggregation, decreased dopamine and its metabolite levels resulting in nigrostriatal neurodegeneration. Pretreatment by Coenzyme Q(10) (4.5 mg/kg ip for 12 weeks) to dichlorvos treated animals significantly attenuated the extent of nigrostriatal neuronal damage, in terms of decreased ROS production, increased dopamine and its metabolite levels, and restoration of motor dysfunction when compared to dichlorvos treated animals. Thus, the present study shows that Coenzyme Q(10) administration may attenuate dichlorvos induced nigrostriatal neurodegeneration, α-synuclein aggregation and motor dysfunction by virtue of its antioxidant action.

Authors+Show Affiliations

Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21843543

Citation

Binukumar, B K., et al. "Protection of Dichlorvos Induced Oxidative Stress and Nigrostriatal Neuronal Death By Chronic Coenzyme Q10 Pretreatment." Toxicology and Applied Pharmacology, vol. 256, no. 1, 2011, pp. 73-82.
Binukumar BK, Gupta N, Bal A, et al. Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic coenzyme Q10 pretreatment. Toxicol Appl Pharmacol. 2011;256(1):73-82.
Binukumar, B. K., Gupta, N., Bal, A., & Gill, K. D. (2011). Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic coenzyme Q10 pretreatment. Toxicology and Applied Pharmacology, 256(1), 73-82. https://doi.org/10.1016/j.taap.2011.07.015
Binukumar BK, et al. Protection of Dichlorvos Induced Oxidative Stress and Nigrostriatal Neuronal Death By Chronic Coenzyme Q10 Pretreatment. Toxicol Appl Pharmacol. 2011 Oct 1;256(1):73-82. PubMed PMID: 21843543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic coenzyme Q10 pretreatment. AU - Binukumar,B K, AU - Gupta,Nidhi, AU - Bal,Amanjit, AU - Gill,Kiran Dip, Y1 - 2011/08/05/ PY - 2011/05/02/received PY - 2011/07/26/revised PY - 2011/07/27/accepted PY - 2011/8/17/entrez PY - 2011/8/17/pubmed PY - 2011/10/28/medline SP - 73 EP - 82 JF - Toxicology and applied pharmacology JO - Toxicol. Appl. Pharmacol. VL - 256 IS - 1 N2 - Numerous epidemiological studies have shown an association between pesticide exposure and increased risk of developing Parkinson's diseases. Oxidative stress generated as a result of mitochondrial dysfunction has been implicated as an important factor in the etiology of Parkinson's disease. Previously, we reported that chronic dichlorvos exposure causes mitochondrial impairments and nigrostriatal neuronal death in rats. The present study was designed to test whether Coenzyme Q(10) (CoQ(10)) administration has any neuroprotective effect against dichlorvos mediated nigrostriatal neuronal death, α-synuclein aggregation, and motor dysfunction. Male albino rats were administered dichlorvos by subcutaneous injection at a dose of 2.5 mg/kg body weight over a period of 12 weeks. Results obtained there after showed that dichlorvos exposure leads to enhanced mitochondrial ROS production, α-synuclein aggregation, decreased dopamine and its metabolite levels resulting in nigrostriatal neurodegeneration. Pretreatment by Coenzyme Q(10) (4.5 mg/kg ip for 12 weeks) to dichlorvos treated animals significantly attenuated the extent of nigrostriatal neuronal damage, in terms of decreased ROS production, increased dopamine and its metabolite levels, and restoration of motor dysfunction when compared to dichlorvos treated animals. Thus, the present study shows that Coenzyme Q(10) administration may attenuate dichlorvos induced nigrostriatal neurodegeneration, α-synuclein aggregation and motor dysfunction by virtue of its antioxidant action. SN - 1096-0333 UR - https://www.unboundmedicine.com/medline/citation/21843543/Protection_of_dichlorvos_induced_oxidative_stress_and_nigrostriatal_neuronal_death_by_chronic_coenzyme_Q10_pretreatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-008X(11)00284-5 DB - PRIME DP - Unbound Medicine ER -