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Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity.
J Ethnopharmacol 2011; 137(3):1300-5JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Traditionally Tagetes erecta Linn flower is claimed to treat skin diseases like sores, burns, wounds, ulcers, eczema and several other skin ailments. The aim of the present experiment was to evaluate the anti-wrinkle potential of standardized flower extract of Tagetes erecta.

MATERIALS AND METHODS

The Tagetes erecta extract and fractions were screened for hyaluronidase, elastase and matrix metalloproteinase (MMP-1) inhibitory activity compared with the activity of standard oleanolic acid. Syringic acid and β-amyrin were obtained from the extract and quantified through RP-HPLC. Also the compounds were evaluated for anti-wrinkle activity.

RESULTS

The methanol extract showed significant ((a)P < 0.05) hyaluronidase and elastase inhibition with IC50 of 11.70 ± 1.79 μg mL(-1) and 4.13 ± 0.93 μg mL(-1) respectively and better MMP-1 inhibition compared to standard oleanolic acid. The isolated compounds syringic acid and β-amyrin found to inhibit enzymes comparable to oleanolic acid. The RP-HPLC analysis revealed that good amounts of syringic acid and β-amyrin (2.30%, w/w and 0.06%) are present in Tagetes erecta.

CONCLUSION

Tagetes erecta flower showed effective inhibition of hyaluronidase, elastase and MMP-1. Therefore, this experiment further rationalizes the traditional uses of this plant, which may be useful as an anti-wrinkle agent.

Authors+Show Affiliations

School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21843618

Citation

Maity, Niladri, et al. "Exploring Tagetes Erecta Linn Flower for the Elastase, Hyaluronidase and MMP-1 Inhibitory Activity." Journal of Ethnopharmacology, vol. 137, no. 3, 2011, pp. 1300-5.
Maity N, Nema NK, Abedy MK, et al. Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity. J Ethnopharmacol. 2011;137(3):1300-5.
Maity, N., Nema, N. K., Abedy, M. K., Sarkar, B. K., & Mukherjee, P. K. (2011). Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity. Journal of Ethnopharmacology, 137(3), pp. 1300-5. doi:10.1016/j.jep.2011.07.064.
Maity N, et al. Exploring Tagetes Erecta Linn Flower for the Elastase, Hyaluronidase and MMP-1 Inhibitory Activity. J Ethnopharmacol. 2011 Oct 11;137(3):1300-5. PubMed PMID: 21843618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity. AU - Maity,Niladri, AU - Nema,Neelesh K, AU - Abedy,Md Karim, AU - Sarkar,Birendra K, AU - Mukherjee,Pulok K, Y1 - 2011/08/05/ PY - 2011/05/21/received PY - 2011/07/28/revised PY - 2011/07/29/accepted PY - 2011/8/17/entrez PY - 2011/8/17/pubmed PY - 2012/2/15/medline SP - 1300 EP - 5 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally Tagetes erecta Linn flower is claimed to treat skin diseases like sores, burns, wounds, ulcers, eczema and several other skin ailments. The aim of the present experiment was to evaluate the anti-wrinkle potential of standardized flower extract of Tagetes erecta. MATERIALS AND METHODS: The Tagetes erecta extract and fractions were screened for hyaluronidase, elastase and matrix metalloproteinase (MMP-1) inhibitory activity compared with the activity of standard oleanolic acid. Syringic acid and β-amyrin were obtained from the extract and quantified through RP-HPLC. Also the compounds were evaluated for anti-wrinkle activity. RESULTS: The methanol extract showed significant ((a)P < 0.05) hyaluronidase and elastase inhibition with IC50 of 11.70 ± 1.79 μg mL(-1) and 4.13 ± 0.93 μg mL(-1) respectively and better MMP-1 inhibition compared to standard oleanolic acid. The isolated compounds syringic acid and β-amyrin found to inhibit enzymes comparable to oleanolic acid. The RP-HPLC analysis revealed that good amounts of syringic acid and β-amyrin (2.30%, w/w and 0.06%) are present in Tagetes erecta. CONCLUSION: Tagetes erecta flower showed effective inhibition of hyaluronidase, elastase and MMP-1. Therefore, this experiment further rationalizes the traditional uses of this plant, which may be useful as an anti-wrinkle agent. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21843618/Exploring_Tagetes_erecta_Linn_flower_for_the_elastase_hyaluronidase_and_MMP_1_inhibitory_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00558-7 DB - PRIME DP - Unbound Medicine ER -