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Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells.
Nanoscale 2011; 3(9):3825-32N

Abstract

The purpose of this work was to develop implantable curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) nanofibers, which might have potential application in cancer therapy. Curcumin was incorporated into biodegradable PCEC nanofibers by electrospinning method. The surface morphology of the composite nanofibers was characterized on Scanning Electron Microscope (SEM). The average diameter of the nanofibers was 2.3-4.5μm. In vitro release behavior of curcumin from the fiber mats was also studied in detail. The in vitro cytotoxicity assay showed that the PCEC fibers themselves did not affect the growth of rat Glioma 9L cells. Antitumor activity of the curcumin-loaded fibers against the cells was kept over the whole experiment process, while the antitumor activity of pure curcumin disappeared within 48 h. These results strongly suggested that the curcumin/PCEC composite nanofibers might have potential application for postoperative chemotherapy of brain cancers.

Authors+Show Affiliations

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21847493

Citation

Guo, Gang, et al. "Preparation of Curcumin Loaded Poly(ε-caprolactone)-poly(ethylene Glycol)-poly(ε-caprolactone) Nanofibers and Their in Vitro Antitumor Activity Against Glioma 9L Cells." Nanoscale, vol. 3, no. 9, 2011, pp. 3825-32.
Guo G, Fu S, Zhou L, et al. Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells. Nanoscale. 2011;3(9):3825-32.
Guo, G., Fu, S., Zhou, L., Liang, H., Fan, M., Luo, F., ... Wei, Y. (2011). Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells. Nanoscale, 3(9), pp. 3825-32. doi:10.1039/c1nr10484e.
Guo G, et al. Preparation of Curcumin Loaded Poly(ε-caprolactone)-poly(ethylene Glycol)-poly(ε-caprolactone) Nanofibers and Their in Vitro Antitumor Activity Against Glioma 9L Cells. Nanoscale. 2011 Sep 1;3(9):3825-32. PubMed PMID: 21847493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells. AU - Guo,Gang, AU - Fu,Shaozhi, AU - Zhou,Liangxue, AU - Liang,Hang, AU - Fan,Min, AU - Luo,Feng, AU - Qian,Zhiyong, AU - Wei,Yuquan, Y1 - 2011/08/17/ PY - 2011/8/18/entrez PY - 2011/8/19/pubmed PY - 2012/1/4/medline SP - 3825 EP - 32 JF - Nanoscale JO - Nanoscale VL - 3 IS - 9 N2 - The purpose of this work was to develop implantable curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) nanofibers, which might have potential application in cancer therapy. Curcumin was incorporated into biodegradable PCEC nanofibers by electrospinning method. The surface morphology of the composite nanofibers was characterized on Scanning Electron Microscope (SEM). The average diameter of the nanofibers was 2.3-4.5μm. In vitro release behavior of curcumin from the fiber mats was also studied in detail. The in vitro cytotoxicity assay showed that the PCEC fibers themselves did not affect the growth of rat Glioma 9L cells. Antitumor activity of the curcumin-loaded fibers against the cells was kept over the whole experiment process, while the antitumor activity of pure curcumin disappeared within 48 h. These results strongly suggested that the curcumin/PCEC composite nanofibers might have potential application for postoperative chemotherapy of brain cancers. SN - 2040-3372 UR - https://www.unboundmedicine.com/medline/citation/21847493/Preparation_of_curcumin_loaded_poly_ε_caprolactone__poly_ethylene_glycol__poly_ε_caprolactone__nanofibers_and_their_in_vitro_antitumor_activity_against_Glioma_9L_cells_ L2 - https://doi.org/10.1039/c1nr10484e DB - PRIME DP - Unbound Medicine ER -