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Cascade reaction of isatins with heterocyclic ketene aminals: synthesis of imidazopyrroloquinoline derivatives.
Org Lett. 2011 Sep 16; 13(18):4782-5.OL

Abstract

A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic ketene aminals (HKAs) by acetic acid was developed. This method is suitable for combinatorial and parallel syntheses in drug discovery; consequently, a library of highly substituted imidazopyrroloquinoline derivatives was rapidly constructed using the present protocol.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yu F
Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.
Yan S
No affiliation info available
Hu L
No affiliation info available
Wang Y
No affiliation info available
Lin J
No affiliation info available

MeSH

Crystallography, X-RayEthylenesHeterocyclic CompoundsIsatinKetonesModels, MolecularMolecular StructureQuinolinesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21848302

Citation

Yu, Fuchao, et al. "Cascade Reaction of Isatins With Heterocyclic Ketene Aminals: Synthesis of Imidazopyrroloquinoline Derivatives." Organic Letters, vol. 13, no. 18, 2011, pp. 4782-5.
Yu F, Yan S, Hu L, et al. Cascade reaction of isatins with heterocyclic ketene aminals: synthesis of imidazopyrroloquinoline derivatives. Org Lett. 2011;13(18):4782-5.
Yu, F., Yan, S., Hu, L., Wang, Y., & Lin, J. (2011). Cascade reaction of isatins with heterocyclic ketene aminals: synthesis of imidazopyrroloquinoline derivatives. Organic Letters, 13(18), 4782-5. https://doi.org/10.1021/ol201783d
Yu F, et al. Cascade Reaction of Isatins With Heterocyclic Ketene Aminals: Synthesis of Imidazopyrroloquinoline Derivatives. Org Lett. 2011 Sep 16;13(18):4782-5. PubMed PMID: 21848302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cascade reaction of isatins with heterocyclic ketene aminals: synthesis of imidazopyrroloquinoline derivatives. AU - Yu,Fuchao, AU - Yan,Shengjiao, AU - Hu,Ling, AU - Wang,Yongchao, AU - Lin,Jun, Y1 - 2011/08/17/ PY - 2011/8/19/entrez PY - 2011/8/19/pubmed PY - 2011/12/13/medline SP - 4782 EP - 5 JF - Organic letters JO - Org Lett VL - 13 IS - 18 N2 - A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic ketene aminals (HKAs) by acetic acid was developed. This method is suitable for combinatorial and parallel syntheses in drug discovery; consequently, a library of highly substituted imidazopyrroloquinoline derivatives was rapidly constructed using the present protocol. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/21848302/Cascade_reaction_of_isatins_with_heterocyclic_ketene_aminals:_synthesis_of_imidazopyrroloquinoline_derivatives_ L2 - https://doi.org/10.1021/ol201783d DB - PRIME DP - Unbound Medicine ER -