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Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis.
Gynecol Endocrinol 2012; 28(3):224-7GE

Abstract

Pelvic endometriosis is a chronic inflammatory disease with an immunological background. Yet there is paucity of contemporary research exploring both the angiogenic cytokines, leptin and IL-8 for a possible role in its pathophysiology.

OBJECTIVE

To compare levels of both leptin and IL-8 in peritoneal fluid (PF) in women with endometriosis vs. fertile controls and correlate with disease stage, type and symptoms.

MATERIALS AND METHODS

PF from 58 women with endometriosis and 28 women undergoing tubal ligation was collected at laparoscopy and leptin and IL-8 levels were measured using ELISA. Results showed significantly higher levels of both cytokines in women with endometriosis. Significantly higher leptin and IL-8 levels were demonstrated in patients with early peritoneal (ASRM stage I and II) and advancing disease (ASRM stage III and IV), respectively. Levels of leptin/IL-8 were significantly lower in patients with endometrioma (4.8 ng/mL/32 pg/mL) vs. implants (13.0 ng/mL/68 pg/mL). There was no correlation of infertility or chronic pelvic pain with these levels.

CONCLUSION

Both leptin and IL-8 levels are raised in PF of women with endometriosis reflecting inflammation and dysregulated immunomodulation. Higher levels of leptin were seen in early stages; IL-8 seems to stimulate the disease in a dose-dependent manner.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India. neenamaltra83@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21848410

Citation

Malhotra, Neena, et al. "Correlation of Angiogenic Cytokines-leptin and IL-8 in Stage, Type and Presentation of Endometriosis." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 28, no. 3, 2012, pp. 224-7.
Malhotra N, Karmakar D, Tripathi V, et al. Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. Gynecol Endocrinol. 2012;28(3):224-7.
Malhotra, N., Karmakar, D., Tripathi, V., Luthra, K., & Kumar, S. (2012). Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 28(3), pp. 224-7. doi:10.3109/09513590.2011.593664.
Malhotra N, et al. Correlation of Angiogenic Cytokines-leptin and IL-8 in Stage, Type and Presentation of Endometriosis. Gynecol Endocrinol. 2012;28(3):224-7. PubMed PMID: 21848410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. AU - Malhotra,Neena, AU - Karmakar,Debjyoti, AU - Tripathi,Vishwas, AU - Luthra,Kalpana, AU - Kumar,Sunesh, Y1 - 2011/08/17/ PY - 2011/8/19/entrez PY - 2011/8/19/pubmed PY - 2012/6/1/medline SP - 224 EP - 7 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 28 IS - 3 N2 - UNLABELLED: Pelvic endometriosis is a chronic inflammatory disease with an immunological background. Yet there is paucity of contemporary research exploring both the angiogenic cytokines, leptin and IL-8 for a possible role in its pathophysiology. OBJECTIVE: To compare levels of both leptin and IL-8 in peritoneal fluid (PF) in women with endometriosis vs. fertile controls and correlate with disease stage, type and symptoms. MATERIALS AND METHODS: PF from 58 women with endometriosis and 28 women undergoing tubal ligation was collected at laparoscopy and leptin and IL-8 levels were measured using ELISA. Results showed significantly higher levels of both cytokines in women with endometriosis. Significantly higher leptin and IL-8 levels were demonstrated in patients with early peritoneal (ASRM stage I and II) and advancing disease (ASRM stage III and IV), respectively. Levels of leptin/IL-8 were significantly lower in patients with endometrioma (4.8 ng/mL/32 pg/mL) vs. implants (13.0 ng/mL/68 pg/mL). There was no correlation of infertility or chronic pelvic pain with these levels. CONCLUSION: Both leptin and IL-8 levels are raised in PF of women with endometriosis reflecting inflammation and dysregulated immunomodulation. Higher levels of leptin were seen in early stages; IL-8 seems to stimulate the disease in a dose-dependent manner. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/21848410/Correlation_of_angiogenic_cytokines_leptin_and_IL_8_in_stage_type_and_presentation_of_endometriosis_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2011.593664 DB - PRIME DP - Unbound Medicine ER -