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[Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16].
Zhongguo Dang Dai Er Ke Za Zhi. 2011 Aug; 13(8):635-7.ZD

Abstract

OBJECTIVE

To compare the differences of epidemiological and clinical characteristics in children with hand-foot-mouth disease (HFMD) caused by Coxsackievirus A16 (CA16) and Enterovirus 71 (EV71).

METHODS

The samples of vesicle fluid and throat swabs of 108 children with HFMD were collected and detected for enterovirus by RT-PCR. The clinical data of children with EV71 and CA16 infection were retrospectively reviewed and compared.

RESULTS

The total positive rate of enterovirus was 97.2% (105/108). Of the 105 cases, 56 cases were positive for EV71 (51.9%), 39 cases were positive for CA16 (36.1%), 2 cases were positive for other enterovirus (1.9%), and 8 cases were co-infected by EV71 and CA16 (7.4%). There were no significant differences in age and sex between EV71 and CV16 infected cases. The univariate analysis showed that the incidences of herpes of mouth, erythra of knees, and nose running in children infected by CA16 were higher than in those infected by EV71. The multivariate logistic regression analysis showed that the HFMD children who had erythra of knees had higher probability of CA16 infection.

CONCLUSIONS

EV71 should be considered as the pathogen in children with HFMD who have no herpes of mouth, erythra of knees, and nose running.

Authors+Show Affiliations

Beijing Center for Disease Prevention and Control, Beijing 100013, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

chi

PubMed ID

21849112

Citation

Jia, Lei, et al. "[Comparisons of Epidemiological and Clinical Characteristics in Children With Hand-foot-mouth Disease Caused By Enterovirus 71 and Coxackievirus A16]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 13, no. 8, 2011, pp. 635-7.
Jia L, Zhao CS, Zhang L, et al. [Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16]. Zhongguo Dang Dai Er Ke Za Zhi. 2011;13(8):635-7.
Jia, L., Zhao, C. S., Zhang, L., Li, S., Zhang, D. T., Liu, B. W., Wang, Q. Y., & Li, X. Y. (2011). [Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 13(8), 635-7.
Jia L, et al. [Comparisons of Epidemiological and Clinical Characteristics in Children With Hand-foot-mouth Disease Caused By Enterovirus 71 and Coxackievirus A16]. Zhongguo Dang Dai Er Ke Za Zhi. 2011;13(8):635-7. PubMed PMID: 21849112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16]. AU - Jia,Lei, AU - Zhao,Cheng-Song, AU - Zhang,Li, AU - Li,Shuang, AU - Zhang,Dai-Tao, AU - Liu,Bai-Wei, AU - Wang,Quan-Yi, AU - Li,Xin-Yu, PY - 2011/8/19/entrez PY - 2011/8/19/pubmed PY - 2011/10/7/medline SP - 635 EP - 7 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 13 IS - 8 N2 - OBJECTIVE: To compare the differences of epidemiological and clinical characteristics in children with hand-foot-mouth disease (HFMD) caused by Coxsackievirus A16 (CA16) and Enterovirus 71 (EV71). METHODS: The samples of vesicle fluid and throat swabs of 108 children with HFMD were collected and detected for enterovirus by RT-PCR. The clinical data of children with EV71 and CA16 infection were retrospectively reviewed and compared. RESULTS: The total positive rate of enterovirus was 97.2% (105/108). Of the 105 cases, 56 cases were positive for EV71 (51.9%), 39 cases were positive for CA16 (36.1%), 2 cases were positive for other enterovirus (1.9%), and 8 cases were co-infected by EV71 and CA16 (7.4%). There were no significant differences in age and sex between EV71 and CV16 infected cases. The univariate analysis showed that the incidences of herpes of mouth, erythra of knees, and nose running in children infected by CA16 were higher than in those infected by EV71. The multivariate logistic regression analysis showed that the HFMD children who had erythra of knees had higher probability of CA16 infection. CONCLUSIONS: EV71 should be considered as the pathogen in children with HFMD who have no herpes of mouth, erythra of knees, and nose running. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/21849112/[Comparisons_of_epidemiological_and_clinical_characteristics_in_children_with_hand_foot_mouth_disease_caused_by_Enterovirus_71_and_Coxackievirus_A16]_ L2 - http://www.zgddek.com/EN/abstract/abstract12622.shtml DB - PRIME DP - Unbound Medicine ER -