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Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: similarities and differences.
J Neurol Sci. 2011 Nov 15; 310(1-2):133-8.JN

Abstract

In Parkinsons disease and multiple system atrophy (MSA), cardiovascular dysfunction may occur for a variety of reasons and may manifest itself through inappropriate changes and/or levels in blood pressure, heart rate and/or regional vascular perfusion in a range of situations. The early occurrence of orthostatic hypotension often leads to consideration of MSA, especially in the presence of other features of autonomic failure. Orthostatic hypotension, however, is increasingly recognised in PD, and especially with increasing age, severity of disease and as a result of drug therapy, sometimes for associated disorders. Investigation of cardiovascular autonomic dysfunction in Parkinsonism is therefore important for a variety of reasons, that include determining the precise diagnosis and in predicting prognosis. In Parkinsonian disorders, understanding the pathophysiological basis of the cardiovascular autonomic dysfunction aids targeting of therapy, improves management strategies and provides benefit for such patients.

Authors+Show Affiliations

Autonomic & Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary's Hospital, South Wharf Road, London W2 1NY, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21849175

Citation

Iodice, Valeria, et al. "Cardiovascular Autonomic Dysfunction in MSA and Parkinson's Disease: Similarities and Differences." Journal of the Neurological Sciences, vol. 310, no. 1-2, 2011, pp. 133-8.
Iodice V, Low DA, Vichayanrat E, et al. Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: similarities and differences. J Neurol Sci. 2011;310(1-2):133-8.
Iodice, V., Low, D. A., Vichayanrat, E., & Mathias, C. J. (2011). Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: similarities and differences. Journal of the Neurological Sciences, 310(1-2), 133-8. https://doi.org/10.1016/j.jns.2011.07.014
Iodice V, et al. Cardiovascular Autonomic Dysfunction in MSA and Parkinson's Disease: Similarities and Differences. J Neurol Sci. 2011 Nov 15;310(1-2):133-8. PubMed PMID: 21849175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: similarities and differences. AU - Iodice,Valeria, AU - Low,David A, AU - Vichayanrat,Ekawat, AU - Mathias,Christopher J, Y1 - 2011/08/16/ PY - 2011/03/28/received PY - 2011/06/27/revised PY - 2011/07/11/accepted PY - 2011/8/19/entrez PY - 2011/8/19/pubmed PY - 2012/2/18/medline SP - 133 EP - 8 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 310 IS - 1-2 N2 - In Parkinsons disease and multiple system atrophy (MSA), cardiovascular dysfunction may occur for a variety of reasons and may manifest itself through inappropriate changes and/or levels in blood pressure, heart rate and/or regional vascular perfusion in a range of situations. The early occurrence of orthostatic hypotension often leads to consideration of MSA, especially in the presence of other features of autonomic failure. Orthostatic hypotension, however, is increasingly recognised in PD, and especially with increasing age, severity of disease and as a result of drug therapy, sometimes for associated disorders. Investigation of cardiovascular autonomic dysfunction in Parkinsonism is therefore important for a variety of reasons, that include determining the precise diagnosis and in predicting prognosis. In Parkinsonian disorders, understanding the pathophysiological basis of the cardiovascular autonomic dysfunction aids targeting of therapy, improves management strategies and provides benefit for such patients. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/21849175/Cardiovascular_autonomic_dysfunction_in_MSA_and_Parkinson's_disease:_similarities_and_differences_ DB - PRIME DP - Unbound Medicine ER -