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The first bis-retrochalcone from Fissistigma latifolium.
Planta Med. 2011 Dec; 77(18):2019-22.PM

Abstract

Two novel chalconoids, [3-3'']bi-2-hydroxy-4,5,6-trimethoxydihydrochalcone (1) and 4,6-dimethoxy-2,5-quinodihydrochalcone (2), and twelve known compounds were isolated from the methanolic extract of Fissistigma latifolium (Dun.) Merr. The structures of all compounds were determined by spectroscopic methods. Of these, compounds 1, 2, and 2-hydroxy-4,5,6-trimethoxydihydrochalcone (10) belong to an uncommon group of chalconoids, the retrochalcones. Compound 1 is the first bis-retrochalcone to be reported, and compound 2 is a quinoretrochalcone. Furthermore, 2 showed activity against the MDA-MB-231 human breast cancer cell line with an IC (50) value of 7.1 µM.

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Publisher Full Text

Authors+Show Affiliations

Lan YH
School of Pharmacy, China Medical University, Taichung, Taiwan. lanyh@mail.cmu.edu.tw
Leu YL
No affiliation info available
Peng YT
No affiliation info available
Thang TD
No affiliation info available
Lin CC
No affiliation info available
Bao BY
No affiliation info available

MeSH

AnnonaceaeAntineoplastic Agents, PhytogenicAporphinesBenzaldehydesCell Line, TumorChalconesFlavonoidsHumansMagnetic Resonance SpectroscopyMethanolMolecular StructurePlant Extracts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21850609

Citation

Lan, Yu-Hsuan, et al. "The First Bis-retrochalcone From Fissistigma Latifolium." Planta Medica, vol. 77, no. 18, 2011, pp. 2019-22.
Lan YH, Leu YL, Peng YT, et al. The first bis-retrochalcone from Fissistigma latifolium. Planta Med. 2011;77(18):2019-22.
Lan, Y. H., Leu, Y. L., Peng, Y. T., Thang, T. D., Lin, C. C., & Bao, B. Y. (2011). The first bis-retrochalcone from Fissistigma latifolium. Planta Medica, 77(18), 2019-22. https://doi.org/10.1055/s-0031-1280088
Lan YH, et al. The First Bis-retrochalcone From Fissistigma Latifolium. Planta Med. 2011;77(18):2019-22. PubMed PMID: 21850609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The first bis-retrochalcone from Fissistigma latifolium. AU - Lan,Yu-Hsuan, AU - Leu,Yann-Lii, AU - Peng,Yi-Ting, AU - Thang,Tran-Dinh, AU - Lin,Chia-Chen, AU - Bao,Bo-Ying, Y1 - 2011/08/17/ PY - 2011/8/19/entrez PY - 2011/8/19/pubmed PY - 2012/4/17/medline SP - 2019 EP - 22 JF - Planta medica JO - Planta Med VL - 77 IS - 18 N2 - Two novel chalconoids, [3-3'']bi-2-hydroxy-4,5,6-trimethoxydihydrochalcone (1) and 4,6-dimethoxy-2,5-quinodihydrochalcone (2), and twelve known compounds were isolated from the methanolic extract of Fissistigma latifolium (Dun.) Merr. The structures of all compounds were determined by spectroscopic methods. Of these, compounds 1, 2, and 2-hydroxy-4,5,6-trimethoxydihydrochalcone (10) belong to an uncommon group of chalconoids, the retrochalcones. Compound 1 is the first bis-retrochalcone to be reported, and compound 2 is a quinoretrochalcone. Furthermore, 2 showed activity against the MDA-MB-231 human breast cancer cell line with an IC (50) value of 7.1 µM. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/21850609/The_first_bis_retrochalcone_from_Fissistigma_latifolium_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1280088 DB - PRIME DP - Unbound Medicine ER -