Tags

Type your tag names separated by a space and hit enter

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents.

Abstract

Obesity in children and adolescents is a worldwide health problem, characterized by various somatic, psychosocial and psychiatric complications, and is often associated with adult obesity and related complications. Brain-derived neurotrophic factor (BDNF) is a neurotrophin with important roles in feeding behavior, food intake regulation, energy metabolism and weight control. A common polymorphism of the BDNF genotype (Val66Met) has been associated with various forms of eating disorders, alterations in body mass index (BMI) values and obesity in adult populations. The aim of this study was to determine the association between the gene variants of the BDNF Val66Met polymorphism and obesity in 300 healthy Caucasian children and adolescents of the same ethnic background of Croatian origin, subdivided according to the BMI percentile, but without any form of eating disorders. The frequency of the Met/Met, Met/Val and Val/Val genotypes, Met and Val alleles, and Met carriers (the combined Met/Met and Met/Val genotypes versus the homozygous Val/Val genotype) differed significantly between underweight, normal weight, overweight and obese children, and the presence of one or two Met alleles contributed to this significant effect. These results showed for the first time the significant association between the presence of one or two Met alleles and obesity in ethnically homogenous groups of healthy Caucasian children and adolescents. These data confirmed the major role of BDNF in energy metabolism, food regulation and BMI.

Authors+Show Affiliations

National Public Health Institute for Zagreb County, Ulica Grada Vukovara 72/V, HR-1000 Zagreb, Croatia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21851847

Citation

Skledar, Marijana, et al. "Association Between Brain-derived Neurotrophic Factor Val66Met and Obesity in Children and Adolescents." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 36, no. 1, 2012, pp. 136-40.
Skledar M, Nikolac M, Dodig-Curkovic K, et al. Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36(1):136-40.
Skledar, M., Nikolac, M., Dodig-Curkovic, K., Curkovic, M., Borovecki, F., & Pivac, N. (2012). Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. Progress in Neuro-psychopharmacology & Biological Psychiatry, 36(1), pp. 136-40. doi:10.1016/j.pnpbp.2011.08.003.
Skledar M, et al. Association Between Brain-derived Neurotrophic Factor Val66Met and Obesity in Children and Adolescents. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):136-40. PubMed PMID: 21851847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents. AU - Skledar,Marijana, AU - Nikolac,Matea, AU - Dodig-Curkovic,Katarina, AU - Curkovic,Mario, AU - Borovecki,Fran, AU - Pivac,Nela, Y1 - 2011/08/07/ PY - 2011/07/15/received PY - 2011/07/25/revised PY - 2011/08/04/accepted PY - 2011/8/20/entrez PY - 2011/8/20/pubmed PY - 2012/8/21/medline SP - 136 EP - 40 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 36 IS - 1 N2 - Obesity in children and adolescents is a worldwide health problem, characterized by various somatic, psychosocial and psychiatric complications, and is often associated with adult obesity and related complications. Brain-derived neurotrophic factor (BDNF) is a neurotrophin with important roles in feeding behavior, food intake regulation, energy metabolism and weight control. A common polymorphism of the BDNF genotype (Val66Met) has been associated with various forms of eating disorders, alterations in body mass index (BMI) values and obesity in adult populations. The aim of this study was to determine the association between the gene variants of the BDNF Val66Met polymorphism and obesity in 300 healthy Caucasian children and adolescents of the same ethnic background of Croatian origin, subdivided according to the BMI percentile, but without any form of eating disorders. The frequency of the Met/Met, Met/Val and Val/Val genotypes, Met and Val alleles, and Met carriers (the combined Met/Met and Met/Val genotypes versus the homozygous Val/Val genotype) differed significantly between underweight, normal weight, overweight and obese children, and the presence of one or two Met alleles contributed to this significant effect. These results showed for the first time the significant association between the presence of one or two Met alleles and obesity in ethnically homogenous groups of healthy Caucasian children and adolescents. These data confirmed the major role of BDNF in energy metabolism, food regulation and BMI. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/21851847/Association_between_brain_derived_neurotrophic_factor_Val66Met_and_obesity_in_children_and_adolescents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(11)00250-8 DB - PRIME DP - Unbound Medicine ER -