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Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning.
Prog Brain Res. 2011; 193:245-55.PB

Abstract

Total sleep deprivation in healthy subjects has a profound effect on the performance on tasks measuring sustained attention or vigilance. We here report how a selective disruption of deep sleep only, that is, selective slow-wave activity (SWA) reduction, affects the performance of healthy well-sleeping subjects on several tasks: a "simple" and a "complex" vigilance task, a declarative learning task, and an implicit learning task despite unchanged duration of sleep. We used automated electroencephalogram (EEG) dependent acoustic feedback aimed at selective interference with-and reduction of-SWA. In a within-subject repeated measures crossover design, performance on the tasks was assessed in 13 elderly adults without sleep complaints after either SWA-reduction or after normal sleep. The number of vigilance lapses increased as a result of SWA reduction, irrespective of the type of vigilance task. Recognition on the declarative memory task was also affected by SWA reduction, associated with a decreased activation of the right hippocampus on encoding (measured with fMRI) suggesting a weaker memory trace. SWA reduction, however, did not affect reaction time on either of the vigilance tasks or implicit memory task performance. These findings suggest a specific role of slow oscillations in the subsequent daytime ability to maintain sustained attention and to encode novel declarative information but not to maintain response speed or to build implicit memories. Of particular interest is that selective SWA reduction can mimic some of the effects of total sleep deprivation, while not affecting sleep duration.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Van Der Werf YD
Department of Sleep and Cognition, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands. y.van.der.werf@nin.knaw.nl
Altena E
No affiliation info available
Vis JC
No affiliation info available
Koene T
No affiliation info available
Van Someren EJ
No affiliation info available

MeSH

Acoustic StimulationAgedAttentionCross-Over StudiesElectroencephalographyFemaleHumansLearningMaleMemoryMiddle AgedNeuropsychological TestsPsychomotor PerformanceReaction TimeSleepSleep Deprivation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21854967

Citation

Van Der Werf, Ysbrand D., et al. "Reduction of Nocturnal Slow-wave Activity Affects Daytime Vigilance Lapses and Memory Encoding but Not Reaction Time or Implicit Learning." Progress in Brain Research, vol. 193, 2011, pp. 245-55.
Van Der Werf YD, Altena E, Vis JC, et al. Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning. Prog Brain Res. 2011;193:245-55.
Van Der Werf, Y. D., Altena, E., Vis, J. C., Koene, T., & Van Someren, E. J. (2011). Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning. Progress in Brain Research, 193, 245-55. https://doi.org/10.1016/B978-0-444-53839-0.00016-8
Van Der Werf YD, et al. Reduction of Nocturnal Slow-wave Activity Affects Daytime Vigilance Lapses and Memory Encoding but Not Reaction Time or Implicit Learning. Prog Brain Res. 2011;193:245-55. PubMed PMID: 21854967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning. AU - Van Der Werf,Ysbrand D, AU - Altena,Ellemarije, AU - Vis,José C, AU - Koene,Teddy, AU - Van Someren,Eus J W, PY - 2011/8/23/entrez PY - 2011/8/23/pubmed PY - 2012/1/10/medline SP - 245 EP - 55 JF - Progress in brain research JO - Prog Brain Res VL - 193 N2 - Total sleep deprivation in healthy subjects has a profound effect on the performance on tasks measuring sustained attention or vigilance. We here report how a selective disruption of deep sleep only, that is, selective slow-wave activity (SWA) reduction, affects the performance of healthy well-sleeping subjects on several tasks: a "simple" and a "complex" vigilance task, a declarative learning task, and an implicit learning task despite unchanged duration of sleep. We used automated electroencephalogram (EEG) dependent acoustic feedback aimed at selective interference with-and reduction of-SWA. In a within-subject repeated measures crossover design, performance on the tasks was assessed in 13 elderly adults without sleep complaints after either SWA-reduction or after normal sleep. The number of vigilance lapses increased as a result of SWA reduction, irrespective of the type of vigilance task. Recognition on the declarative memory task was also affected by SWA reduction, associated with a decreased activation of the right hippocampus on encoding (measured with fMRI) suggesting a weaker memory trace. SWA reduction, however, did not affect reaction time on either of the vigilance tasks or implicit memory task performance. These findings suggest a specific role of slow oscillations in the subsequent daytime ability to maintain sustained attention and to encode novel declarative information but not to maintain response speed or to build implicit memories. Of particular interest is that selective SWA reduction can mimic some of the effects of total sleep deprivation, while not affecting sleep duration. SN - 1875-7855 UR - https://www.unboundmedicine.com/medline/citation/21854967/Reduction_of_nocturnal_slow_wave_activity_affects_daytime_vigilance_lapses_and_memory_encoding_but_not_reaction_time_or_implicit_learning_ DB - PRIME DP - Unbound Medicine ER -