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Different susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced nigro-striatal dopaminergic cell loss between C57BL/6 and BALB/c mice is not related to the difference of monoamine oxidase-B (MAO-B).
Exp Toxicol Pathol. 2013 Jan; 65(1-2):153-8.ET

Abstract

Subcutaneous and intraperitoneal administrations of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induce selective dopaminergic (DA-ergic) neuronal death in many animal species. After passing through the blood-brain barrier (BBB), MPTP is converted to 1-methy-4-phenylpiridinium (MPP(+)) by astrocytic monoamine oxidase-B (MAO-B). MPP(+) then induces the dopaminergic neuronal death. In mice, marked strain differences in the susceptibility to MPTP-injection have been reported. To clarify which factor(s) cause the strain differences, MPTP or MPP(+) was intracerebroventricularly (icv) injected into adult C57BL/6 (highly susceptible to MPTP) and BALB/c (resistant to MPTP) mice. The brain tissues including the striatum and substantia nigra pars compacta (SNpc) were examined immunohistochemically using an antibody to tyrosine hydrocyrase (TH). MPP(+)-injected C57BL/6 mice showed a significant decrease in TH-immunopositive areas in the striatum at Day 3 post injection (p<0.01), and TH-positive cells in the SNpc at Days 1 and 3 (p<0.01), respectively, compared to saline-injected control mice. In addition, MPP(+)-injected BALB/c mice showed a significant decrease in TH-positive areas in the striatum at Days 1 and 3, and SNpc TH-positive cells in the SNpc at Day 3, respectively (p<0.05). However, the decrease rates in the BALB/c mice were lower than that in C57BL/6 mice. MPTP-injected C57BL/6 mice, however, showed no lesions in the striatum and SNpc at Days 1 and 7 after icv injection. All the present findings indicate that factors other than MAO-B can influence the strain susceptibility between C57BL/6 and BALB/c mice after the conversion from MPTP to MPP(+).

Authors+Show Affiliations

Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21855308

Citation

Ito, Tsuyoshi, et al. "Different Susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced Nigro-striatal Dopaminergic Cell Loss Between C57BL/6 and BALB/c Mice Is Not Related to the Difference of Monoamine oxidase-B (MAO-B)." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 65, no. 1-2, 2013, pp. 153-8.
Ito T, Suzuki K, Uchida K, et al. Different susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced nigro-striatal dopaminergic cell loss between C57BL/6 and BALB/c mice is not related to the difference of monoamine oxidase-B (MAO-B). Exp Toxicol Pathol. 2013;65(1-2):153-8.
Ito, T., Suzuki, K., Uchida, K., & Nakayama, H. (2013). Different susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced nigro-striatal dopaminergic cell loss between C57BL/6 and BALB/c mice is not related to the difference of monoamine oxidase-B (MAO-B). Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 65(1-2), 153-8. https://doi.org/10.1016/j.etp.2011.07.004
Ito T, et al. Different Susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced Nigro-striatal Dopaminergic Cell Loss Between C57BL/6 and BALB/c Mice Is Not Related to the Difference of Monoamine oxidase-B (MAO-B). Exp Toxicol Pathol. 2013;65(1-2):153-8. PubMed PMID: 21855308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different susceptibility to 1-methyl-4-phenylpyridium (MPP(+))-induced nigro-striatal dopaminergic cell loss between C57BL/6 and BALB/c mice is not related to the difference of monoamine oxidase-B (MAO-B). AU - Ito,Tsuyoshi, AU - Suzuki,Kazuhiko, AU - Uchida,Kazuyuki, AU - Nakayama,Hiroyuki, Y1 - 2011/08/19/ PY - 2010/10/26/received PY - 2011/06/01/revised PY - 2011/07/22/accepted PY - 2011/8/23/entrez PY - 2011/8/23/pubmed PY - 2013/5/8/medline SP - 153 EP - 8 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp Toxicol Pathol VL - 65 IS - 1-2 N2 - Subcutaneous and intraperitoneal administrations of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induce selective dopaminergic (DA-ergic) neuronal death in many animal species. After passing through the blood-brain barrier (BBB), MPTP is converted to 1-methy-4-phenylpiridinium (MPP(+)) by astrocytic monoamine oxidase-B (MAO-B). MPP(+) then induces the dopaminergic neuronal death. In mice, marked strain differences in the susceptibility to MPTP-injection have been reported. To clarify which factor(s) cause the strain differences, MPTP or MPP(+) was intracerebroventricularly (icv) injected into adult C57BL/6 (highly susceptible to MPTP) and BALB/c (resistant to MPTP) mice. The brain tissues including the striatum and substantia nigra pars compacta (SNpc) were examined immunohistochemically using an antibody to tyrosine hydrocyrase (TH). MPP(+)-injected C57BL/6 mice showed a significant decrease in TH-immunopositive areas in the striatum at Day 3 post injection (p<0.01), and TH-positive cells in the SNpc at Days 1 and 3 (p<0.01), respectively, compared to saline-injected control mice. In addition, MPP(+)-injected BALB/c mice showed a significant decrease in TH-positive areas in the striatum at Days 1 and 3, and SNpc TH-positive cells in the SNpc at Day 3, respectively (p<0.05). However, the decrease rates in the BALB/c mice were lower than that in C57BL/6 mice. MPTP-injected C57BL/6 mice, however, showed no lesions in the striatum and SNpc at Days 1 and 7 after icv injection. All the present findings indicate that factors other than MAO-B can influence the strain susceptibility between C57BL/6 and BALB/c mice after the conversion from MPTP to MPP(+). SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/21855308/Different_susceptibility_to_1_methyl_4_phenylpyridium__MPP_+___induced_nigro_striatal_dopaminergic_cell_loss_between_C57BL/6_and_BALB/c_mice_is_not_related_to_the_difference_of_monoamine_oxidase_B__MAO_B__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(11)00107-2 DB - PRIME DP - Unbound Medicine ER -