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Curcumin-mediated lifespan extension in Caenorhabditis elegans.
Mech Ageing Dev 2011; 132(10):480-7MA

Abstract

Curcumin is the active ingredient in the herbal medicine and dietary spice, turmeric (Curcuma longa). It has a wide range of biological activities, including anti-inflammatory, antioxidant, chemopreventive, and chemotherapeutic activities. We examined the effects of curcumin on the lifespan and aging in Caenorhabditis elegans, and found that it responded to curcumin with an increased lifespan and reduced intracellular reactive oxygen species and lipofuscin during aging. We analyzed factors that might influence lifespan extension by curcumin. We showed that lifespan extension by curcumin in C. elegans is attributed to its antioxidative properties but not its antimicrobial properties. Moreover, we showed that lifespan extension had effects on body size and the pharyngeal pumping rate but not on reproduction. Finally, lifespan tests with selected stress- and lifespan-relevant mutant strains revealed that the lifespan-extending phenotype was absent from the osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1 mutants, whereas curcumin treatment prolonged the lifespan of mev-1 and daf-16 mutants. Our study has unraveled a diversity of modes of action and signaling pathways to longevity and aging with curcumin exposure in vivo.

Authors+Show Affiliations

Department of Bioenvironmental Systems Engineering, National Taiwan University, No. 1 Roosevelt Road, Sec. 4, Taipei 106, Taiwan. vivianliao@ntu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21855561

Citation

Liao, Vivian Hsiu-Chuan, et al. "Curcumin-mediated Lifespan Extension in Caenorhabditis Elegans." Mechanisms of Ageing and Development, vol. 132, no. 10, 2011, pp. 480-7.
Liao VH, Yu CW, Chu YJ, et al. Curcumin-mediated lifespan extension in Caenorhabditis elegans. Mech Ageing Dev. 2011;132(10):480-7.
Liao, V. H., Yu, C. W., Chu, Y. J., Li, W. H., Hsieh, Y. C., & Wang, T. T. (2011). Curcumin-mediated lifespan extension in Caenorhabditis elegans. Mechanisms of Ageing and Development, 132(10), pp. 480-7. doi:10.1016/j.mad.2011.07.008.
Liao VH, et al. Curcumin-mediated Lifespan Extension in Caenorhabditis Elegans. Mech Ageing Dev. 2011;132(10):480-7. PubMed PMID: 21855561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin-mediated lifespan extension in Caenorhabditis elegans. AU - Liao,Vivian Hsiu-Chuan, AU - Yu,Chan-Wei, AU - Chu,Yu-Ju, AU - Li,Wen-Hsuan, AU - Hsieh,Yi-Chen, AU - Wang,Teng-Ting, Y1 - 2011/08/09/ PY - 2011/02/17/received PY - 2011/06/30/revised PY - 2011/07/31/accepted PY - 2011/8/23/entrez PY - 2011/8/23/pubmed PY - 2012/1/17/medline SP - 480 EP - 7 JF - Mechanisms of ageing and development JO - Mech. Ageing Dev. VL - 132 IS - 10 N2 - Curcumin is the active ingredient in the herbal medicine and dietary spice, turmeric (Curcuma longa). It has a wide range of biological activities, including anti-inflammatory, antioxidant, chemopreventive, and chemotherapeutic activities. We examined the effects of curcumin on the lifespan and aging in Caenorhabditis elegans, and found that it responded to curcumin with an increased lifespan and reduced intracellular reactive oxygen species and lipofuscin during aging. We analyzed factors that might influence lifespan extension by curcumin. We showed that lifespan extension by curcumin in C. elegans is attributed to its antioxidative properties but not its antimicrobial properties. Moreover, we showed that lifespan extension had effects on body size and the pharyngeal pumping rate but not on reproduction. Finally, lifespan tests with selected stress- and lifespan-relevant mutant strains revealed that the lifespan-extending phenotype was absent from the osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1 mutants, whereas curcumin treatment prolonged the lifespan of mev-1 and daf-16 mutants. Our study has unraveled a diversity of modes of action and signaling pathways to longevity and aging with curcumin exposure in vivo. SN - 1872-6216 UR - https://www.unboundmedicine.com/medline/citation/21855561/Curcumin_mediated_lifespan_extension_in_Caenorhabditis_elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047-6374(11)00118-7 DB - PRIME DP - Unbound Medicine ER -