Tags

Type your tag names separated by a space and hit enter

Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Int J Parasitol. 2011 Sep; 41(11):1175-83.IJ

Abstract

The rat lugworm Angiostrongylus cantonensis can cause eosinophilic meningitis. The purpose of this study was to determine whether matrix metalloproteinase (MMP)-12 and its substrate elastin participate in this inflammatory response. We showed that the MMP-12/tissue inhibitor of metalloproteinase-1 ratio was significantly increased in the CSF of A. cantonensis-infected mice from day 10 p.i., and reached high levels on days 20 and 25 p.i. MMP-12 production was correlated with elastin degradation, eosinophil count, blood-CSF barrier permeability and pathological changes in the subarachnoid space. Also, MMP-12 might contribute to elastin degradation in the meningeal vessel of the subarachnoid space. Simultaneous administration of albendazole and doxycycline significantly reduced the levels of MMP-12, elastin and Evans blue in mice with meningitis. These results imply that MMP-12 contributes to the elastin degradation that occurs in angiostrongyliasis meningitis, and doxycycline can reverse related inflammatory events by inhibition of MMP-12.

Authors+Show Affiliations

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21856305

Citation

Wei, P C., et al. "Matrix Metalloproteinase-12 Leads to Elastin Degradation in BALB/c Mice With Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis." International Journal for Parasitology, vol. 41, no. 11, 2011, pp. 1175-83.
Wei PC, Tsai CH, Chiu PS, et al. Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Int J Parasitol. 2011;41(11):1175-83.
Wei, P. C., Tsai, C. H., Chiu, P. S., & Lai, S. C. (2011). Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. International Journal for Parasitology, 41(11), 1175-83. https://doi.org/10.1016/j.ijpara.2011.07.002
Wei PC, et al. Matrix Metalloproteinase-12 Leads to Elastin Degradation in BALB/c Mice With Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis. Int J Parasitol. 2011;41(11):1175-83. PubMed PMID: 21856305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. AU - Wei,P C, AU - Tsai,C H, AU - Chiu,P S, AU - Lai,S C, Y1 - 2011/08/06/ PY - 2011/05/26/received PY - 2011/07/07/revised PY - 2011/07/08/accepted PY - 2011/8/23/entrez PY - 2011/8/23/pubmed PY - 2011/12/20/medline SP - 1175 EP - 83 JF - International journal for parasitology JO - Int J Parasitol VL - 41 IS - 11 N2 - The rat lugworm Angiostrongylus cantonensis can cause eosinophilic meningitis. The purpose of this study was to determine whether matrix metalloproteinase (MMP)-12 and its substrate elastin participate in this inflammatory response. We showed that the MMP-12/tissue inhibitor of metalloproteinase-1 ratio was significantly increased in the CSF of A. cantonensis-infected mice from day 10 p.i., and reached high levels on days 20 and 25 p.i. MMP-12 production was correlated with elastin degradation, eosinophil count, blood-CSF barrier permeability and pathological changes in the subarachnoid space. Also, MMP-12 might contribute to elastin degradation in the meningeal vessel of the subarachnoid space. Simultaneous administration of albendazole and doxycycline significantly reduced the levels of MMP-12, elastin and Evans blue in mice with meningitis. These results imply that MMP-12 contributes to the elastin degradation that occurs in angiostrongyliasis meningitis, and doxycycline can reverse related inflammatory events by inhibition of MMP-12. SN - 1879-0135 UR - https://www.unboundmedicine.com/medline/citation/21856305/Matrix_metalloproteinase_12_leads_to_elastin_degradation_in_BALB/c_mice_with_eosinophilic_meningitis_caused_by_Angiostrongylus_cantonensis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-7519(11)00197-4 DB - PRIME DP - Unbound Medicine ER -