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The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy.
J Ethnopharmacol. 2011 Oct 11; 137(3):1409-14.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Diabetic nephropathy (DN) is the most common cause of end stage renal disease. In this study, the effects of Salvia miltiorrhiza (SM) were studied in an experimental rat model of DN that was induced by streptozotocin (STZ) treatment.

MATERIALS AND METHODS

Diabetes was induced in male Sprague-Dawley rats (290 ± 10 g) by injecting STZ (45 mg/kg) into the tail vein. After development of diabetes, the rats were treated with SM (500 mg/kg) for 8 weeks in order to analyze its renoprotective effect, which was evaluated by means of blood glucose level, urine protein, and the expression of advanced glycation end-products (AGEs), receptor of advanced glycation end-products (RAGE), transforming growth factor β1 (TGF-β1), collagen IV, and monocyte/macrophage (ED-1) infiltration.

RESULTS

High levels of 24-h urinary protein excretion were ameliorated by SM. Moreover, the serum and kidney levels of transforming growth factor β1 (TGF-β1) and the kidney levels of collagen IV, monocytes/macrophages (ED-1) and the receptor for advanced glycation end-products (RAGE), were significantly reduced.

CONCLUSIONS

These findings suggest that SM might inhibit the progression of DN and could be a therapeutic agent for regulating several pharmacological targets for treatment or prevention of DN.

Authors+Show Affiliations

Deptatment of Clinical Oncology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21856399

Citation

Lee, Sang-Hun, et al. "The Protective Effect of Salvia Miltiorrhiza in an Animal Model of Early Experimentally Induced Diabetic Nephropathy." Journal of Ethnopharmacology, vol. 137, no. 3, 2011, pp. 1409-14.
Lee SH, Kim YS, Lee SJ, et al. The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy. J Ethnopharmacol. 2011;137(3):1409-14.
Lee, S. H., Kim, Y. S., Lee, S. J., & Lee, B. C. (2011). The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy. Journal of Ethnopharmacology, 137(3), 1409-14. https://doi.org/10.1016/j.jep.2011.08.007
Lee SH, et al. The Protective Effect of Salvia Miltiorrhiza in an Animal Model of Early Experimentally Induced Diabetic Nephropathy. J Ethnopharmacol. 2011 Oct 11;137(3):1409-14. PubMed PMID: 21856399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy. AU - Lee,Sang-Hun, AU - Kim,Young-Seok, AU - Lee,Seung-Jin, AU - Lee,Byung-Cheol, Y1 - 2011/08/11/ PY - 2011/04/22/received PY - 2011/08/01/revised PY - 2011/08/02/accepted PY - 2011/8/23/entrez PY - 2011/8/23/pubmed PY - 2012/2/15/medline SP - 1409 EP - 14 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is the most common cause of end stage renal disease. In this study, the effects of Salvia miltiorrhiza (SM) were studied in an experimental rat model of DN that was induced by streptozotocin (STZ) treatment. MATERIALS AND METHODS: Diabetes was induced in male Sprague-Dawley rats (290 ± 10 g) by injecting STZ (45 mg/kg) into the tail vein. After development of diabetes, the rats were treated with SM (500 mg/kg) for 8 weeks in order to analyze its renoprotective effect, which was evaluated by means of blood glucose level, urine protein, and the expression of advanced glycation end-products (AGEs), receptor of advanced glycation end-products (RAGE), transforming growth factor β1 (TGF-β1), collagen IV, and monocyte/macrophage (ED-1) infiltration. RESULTS: High levels of 24-h urinary protein excretion were ameliorated by SM. Moreover, the serum and kidney levels of transforming growth factor β1 (TGF-β1) and the kidney levels of collagen IV, monocytes/macrophages (ED-1) and the receptor for advanced glycation end-products (RAGE), were significantly reduced. CONCLUSIONS: These findings suggest that SM might inhibit the progression of DN and could be a therapeutic agent for regulating several pharmacological targets for treatment or prevention of DN. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21856399/The_protective_effect_of_Salvia_miltiorrhiza_in_an_animal_model_of_early_experimentally_induced_diabetic_nephropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00580-0 DB - PRIME DP - Unbound Medicine ER -