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Synaptic connections of the neurokinin 1 receptor-like immunoreactive neurons in the rat medullary dorsal horn.
PLoS One. 2011; 6(8):e23275.Plos

Abstract

The synaptic connections between neurokinin 1 (NK1) receptor-like immunoreactive (LI) neurons and γ-aminobutyric acid (GABA)-, glycine (Gly)-, serotonin (5-HT)- or dopamine-β-hydroxylase (DBH, a specific marker for norepinephrinergic neuronal structures)-LI axon terminals in the rat medullary dorsal horn (MDH) were examined under electron microscope by using a pre-embedding immunohistochemical double-staining technique. NK1 receptor-LI neurons were observed principally in laminae I and III, only a few of them were found in lamina II of the MDH. GABA-, Gly-, 5-HT-, or DBH-LI axon terminals were densely encountered in laminae I and II, and sparsely in lamina III of the MDH. Some of these GABA-, Gly-, 5-HT-, or DBH-LI axon terminals were observed to make principally symmetric synapses with NK1 receptor-LI neuronal cell bodies and dendritic processes in laminae I, II and III of the MDH. The present results suggest that neurons expressing NK1 receptor within the MDH might be modulated by GABAergic and glycinergic inhibitory intrinsic neurons located in the MDH and 5-HT- or norepinephrine (NE)-containing descending fibers originated from structures in the brainstem.

Authors+Show Affiliations

Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21858052

Citation

Qi, Jian, et al. "Synaptic Connections of the Neurokinin 1 Receptor-like Immunoreactive Neurons in the Rat Medullary Dorsal Horn." PloS One, vol. 6, no. 8, 2011, pp. e23275.
Qi J, Zhang H, Guo J, et al. Synaptic connections of the neurokinin 1 receptor-like immunoreactive neurons in the rat medullary dorsal horn. PLoS ONE. 2011;6(8):e23275.
Qi, J., Zhang, H., Guo, J., Yang, L., Wang, W., Chen, T., Li, H., Wu, S. X., & Li, Y. Q. (2011). Synaptic connections of the neurokinin 1 receptor-like immunoreactive neurons in the rat medullary dorsal horn. PloS One, 6(8), e23275. https://doi.org/10.1371/journal.pone.0023275
Qi J, et al. Synaptic Connections of the Neurokinin 1 Receptor-like Immunoreactive Neurons in the Rat Medullary Dorsal Horn. PLoS ONE. 2011;6(8):e23275. PubMed PMID: 21858052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synaptic connections of the neurokinin 1 receptor-like immunoreactive neurons in the rat medullary dorsal horn. AU - Qi,Jian, AU - Zhang,Hua, AU - Guo,Jun, AU - Yang,Le, AU - Wang,Wen, AU - Chen,Tao, AU - Li,Hui, AU - Wu,Sheng-Xi, AU - Li,Yun-Qing, Y1 - 2011/08/17/ PY - 2011/04/22/received PY - 2011/07/10/accepted PY - 2011/8/23/entrez PY - 2011/8/23/pubmed PY - 2012/2/16/medline SP - e23275 EP - e23275 JF - PloS one JO - PLoS ONE VL - 6 IS - 8 N2 - The synaptic connections between neurokinin 1 (NK1) receptor-like immunoreactive (LI) neurons and γ-aminobutyric acid (GABA)-, glycine (Gly)-, serotonin (5-HT)- or dopamine-β-hydroxylase (DBH, a specific marker for norepinephrinergic neuronal structures)-LI axon terminals in the rat medullary dorsal horn (MDH) were examined under electron microscope by using a pre-embedding immunohistochemical double-staining technique. NK1 receptor-LI neurons were observed principally in laminae I and III, only a few of them were found in lamina II of the MDH. GABA-, Gly-, 5-HT-, or DBH-LI axon terminals were densely encountered in laminae I and II, and sparsely in lamina III of the MDH. Some of these GABA-, Gly-, 5-HT-, or DBH-LI axon terminals were observed to make principally symmetric synapses with NK1 receptor-LI neuronal cell bodies and dendritic processes in laminae I, II and III of the MDH. The present results suggest that neurons expressing NK1 receptor within the MDH might be modulated by GABAergic and glycinergic inhibitory intrinsic neurons located in the MDH and 5-HT- or norepinephrine (NE)-containing descending fibers originated from structures in the brainstem. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/21858052/Synaptic_connections_of_the_neurokinin_1_receptor_like_immunoreactive_neurons_in_the_rat_medullary_dorsal_horn_ L2 - http://dx.plos.org/10.1371/journal.pone.0023275 DB - PRIME DP - Unbound Medicine ER -