Tags

Type your tag names separated by a space and hit enter

Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern.
World J Gastrointest Pathophysiol. 2011 Jun 15; 2(3):42-8.WJ

Abstract

AIM

To investigate differences in the physiopathological findings (manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease (NERD) and erosive reflux disease (ERD) found positive at 24 h pH monitoring.

METHODS

For a total of 670 patients who underwent 24 h pH monitoring, esophageal manometry and upper endoscopy were retrospectively evaluated, assessing the reflux symptoms, manometric characteristics of the lower esophageal sphincter (LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study, patients had to have NERD or ERD and be found positive on pH monitoring (NERD+). Patients with Gastroesophageal reflux disease (GERD) complicated by stenosis, ulcers or Barrett's esophagus were ruled out.

RESULTS

214 patients were involved in the study, i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender- or age-related differences between the two groups. The ERD group had more cases of hiatal hernia (P = 0.02) and more acid reflux, both in terms of number of reflux episodes (P = 0.01) and as a percentage of the total time with a pH < 4 (P = 0.00), when upright (P = 0.007) and supine (P = 0.00). The NERD+ cases had more reflux episodes while upright (P = 0.02) and the ERD cases while supine (P = 0.01). The LES pressure was higher in cases of NERD+ (P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group (P >0.05). The NERD+ patients presented more often with atypical symptoms (P = 0.01).

CONCLUSION

The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position (unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments.

Authors+Show Affiliations

Vittorio Bresadola, Gian Luigi Adani, Francesco Londero, Cosimo Alex Leo, Vittorio Cherchi, Dario Lorenzin, Anna Rossetto, Gianmatteo Vit, Umberto Baccarani, Giovanni Terrosu, Dino De Anna, Department of Surgery and Transplantation, University Hospital of Udine, P.le S.M. della Misericordia, Udine 33100, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21860835

Citation

Bresadola, Vittorio, et al. "Non-erosive and Uncomplicated Erosive Reflux Diseases: Difference in Physiopathological and Symptom Pattern." World Journal of Gastrointestinal Pathophysiology, vol. 2, no. 3, 2011, pp. 42-8.
Bresadola V, Adani GL, Londero F, et al. Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern. World J Gastrointest Pathophysiol. 2011;2(3):42-8.
Bresadola, V., Adani, G. L., Londero, F., Leo, C. A., Cherchi, V., Lorenzin, D., Rossetto, A., Vit, G., Baccarani, U., Terrosu, G., & Anna, D. D. (2011). Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern. World Journal of Gastrointestinal Pathophysiology, 2(3), 42-8. https://doi.org/10.4291/wjgp.v2.i3.42
Bresadola V, et al. Non-erosive and Uncomplicated Erosive Reflux Diseases: Difference in Physiopathological and Symptom Pattern. World J Gastrointest Pathophysiol. 2011 Jun 15;2(3):42-8. PubMed PMID: 21860835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern. AU - Bresadola,Vittorio, AU - Adani,Gian Luigi, AU - Londero,Francesco, AU - Leo,Cosimo Alex, AU - Cherchi,Vittorio, AU - Lorenzin,Dario, AU - Rossetto,Anna, AU - Vit,Gianmatteo, AU - Baccarani,Umberto, AU - Terrosu,Giovanni, AU - Anna,Dino De, PY - 2010/12/09/received PY - 2011/01/31/revised PY - 2011/04/07/accepted PY - 2011/8/24/entrez PY - 2011/8/24/pubmed PY - 2011/8/24/medline KW - Barrett’s esophagus KW - Erosive reflux disease KW - Gastroesophageal reflux disease KW - Non-erosive reflux disease KW - Reflux symptoms SP - 42 EP - 8 JF - World journal of gastrointestinal pathophysiology JO - World J Gastrointest Pathophysiol VL - 2 IS - 3 N2 - AIM: To investigate differences in the physiopathological findings (manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease (NERD) and erosive reflux disease (ERD) found positive at 24 h pH monitoring. METHODS: For a total of 670 patients who underwent 24 h pH monitoring, esophageal manometry and upper endoscopy were retrospectively evaluated, assessing the reflux symptoms, manometric characteristics of the lower esophageal sphincter (LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study, patients had to have NERD or ERD and be found positive on pH monitoring (NERD+). Patients with Gastroesophageal reflux disease (GERD) complicated by stenosis, ulcers or Barrett's esophagus were ruled out. RESULTS: 214 patients were involved in the study, i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender- or age-related differences between the two groups. The ERD group had more cases of hiatal hernia (P = 0.02) and more acid reflux, both in terms of number of reflux episodes (P = 0.01) and as a percentage of the total time with a pH < 4 (P = 0.00), when upright (P = 0.007) and supine (P = 0.00). The NERD+ cases had more reflux episodes while upright (P = 0.02) and the ERD cases while supine (P = 0.01). The LES pressure was higher in cases of NERD+ (P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group (P >0.05). The NERD+ patients presented more often with atypical symptoms (P = 0.01). CONCLUSION: The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position (unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments. SN - 2150-5330 UR - https://www.unboundmedicine.com/medline/citation/21860835/Non_erosive_and_uncomplicated_erosive_reflux_diseases:_Difference_in_physiopathological_and_symptom_pattern_ L2 - http://www.wjgnet.com/2150-5330/full/v2/i3/42.htm DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.