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Frequency of oral mucositis and microbiological analysis in children with acute lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate.
Braz Dent J 2011; 22(4):312-6BD

Abstract

In view of the morbidity potential of oral complications in patients with leukemia, this study evaluated the clinical and microbiological alterations that occur in the oral mucosa of children with acute lymphoblastic leukemia (ALL) undergoing antineoplastic chemotherapy and prophylactic administration of 0.12% chlorhexidine gluconate. The sample consisted of 17 children aged 2 to 12 years that underwent clinical examination of the oral mucosa for the detection of oral lesions. In addition, biological material was collected from labial and buccal mucosa for microbiological analysis. Oral mucositis was observed in only 5 (29.4%) patients. Microbiological analysis revealed a reduced number of potentially pathogenic microorganisms, such as coagulase-negative staphylococci (47%), Candida albicans (35.3%), Klebsiella pneumoniae (5.9%), enteropathogenic Escherichia coli (5.9%), and Stenotrophomonas maltophilia (5.9%). Patients with oral mucositis showed a higher frequency of coagulase-negative staphylococci (80%) when compared with patients with normal oral mucosa (33.3%). In conclusion, the results of the present study suggest that the prophylactic use of 0.12% chlorhexidine gluconate reduces the frequency of oral mucositis and oral pathogens in children with ALL. In addition, the present findings suggest a possible relationship between coagulase-negative staphylococci and the development of oral mucositis.

Authors+Show Affiliations

Department of Morphology, Dental School, UFS - Federal University of Sergipe, Aracaju, SE, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21861031

Citation

Soares, Andréa Ferreira, et al. "Frequency of Oral Mucositis and Microbiological Analysis in Children With Acute Lymphoblastic Leukemia Treated With 0.12% Chlorhexidine Gluconate." Brazilian Dental Journal, vol. 22, no. 4, 2011, pp. 312-6.
Soares AF, Aquino AR, Carvalho CH, et al. Frequency of oral mucositis and microbiological analysis in children with acute lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate. Braz Dent J. 2011;22(4):312-6.
Soares, A. F., Aquino, A. R., Carvalho, C. H., Nonaka, C. F., Almeida, D., & Pinto, L. P. (2011). Frequency of oral mucositis and microbiological analysis in children with acute lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate. Brazilian Dental Journal, 22(4), pp. 312-6.
Soares AF, et al. Frequency of Oral Mucositis and Microbiological Analysis in Children With Acute Lymphoblastic Leukemia Treated With 0.12% Chlorhexidine Gluconate. Braz Dent J. 2011;22(4):312-6. PubMed PMID: 21861031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of oral mucositis and microbiological analysis in children with acute lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate. AU - Soares,Andréa Ferreira, AU - Aquino,Ana Rafaela Luz de, AU - Carvalho,Cyntia Helena Pereira de, AU - Nonaka,Cassiano Francisco Weege, AU - Almeida,Dulce, AU - Pinto,Leão Pereira, PY - 2010/11/10/received PY - 2011/06/02/accepted PY - 2011/8/24/entrez PY - 2011/8/24/pubmed PY - 2011/12/30/medline SP - 312 EP - 6 JF - Brazilian dental journal JO - Braz Dent J VL - 22 IS - 4 N2 - In view of the morbidity potential of oral complications in patients with leukemia, this study evaluated the clinical and microbiological alterations that occur in the oral mucosa of children with acute lymphoblastic leukemia (ALL) undergoing antineoplastic chemotherapy and prophylactic administration of 0.12% chlorhexidine gluconate. The sample consisted of 17 children aged 2 to 12 years that underwent clinical examination of the oral mucosa for the detection of oral lesions. In addition, biological material was collected from labial and buccal mucosa for microbiological analysis. Oral mucositis was observed in only 5 (29.4%) patients. Microbiological analysis revealed a reduced number of potentially pathogenic microorganisms, such as coagulase-negative staphylococci (47%), Candida albicans (35.3%), Klebsiella pneumoniae (5.9%), enteropathogenic Escherichia coli (5.9%), and Stenotrophomonas maltophilia (5.9%). Patients with oral mucositis showed a higher frequency of coagulase-negative staphylococci (80%) when compared with patients with normal oral mucosa (33.3%). In conclusion, the results of the present study suggest that the prophylactic use of 0.12% chlorhexidine gluconate reduces the frequency of oral mucositis and oral pathogens in children with ALL. In addition, the present findings suggest a possible relationship between coagulase-negative staphylococci and the development of oral mucositis. SN - 1806-4760 UR - https://www.unboundmedicine.com/medline/citation/21861031/Frequency_of_oral_mucositis_and_microbiological_analysis_in_children_with_acute_lymphoblastic_leukemia_treated_with_0_12_chlorhexidine_gluconate_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402011000400009&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -