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The relationship between self-monitoring of blood glucose results and glycated haemoglobin in type 2 diabetes: the fremantle diabetes study.
Diabetes Res Clin Pract. 2011 Dec; 94(3):371-6.DR

Abstract

The benefits of self-monitoring of blood glucose (SMBG) in type 2 diabetes remain contentious. If SMBG data do not accurately reflect HbA(1c), attempts to modify lifestyle/pharmacotherapy will be ineffective. We aimed to determine how well SMBG correlates with HbA(1c) and fasting serum glucose (FSG). Community-based type 2 patients using SMBG provided their highest and lowest pre- and post-prandial glucose results in the week before detailed assessment. The ability of average pre- and post-prandial SMBG to predict HbA(1c)>7.0% was determined by linear regression and receiver operating characteristic (ROC) analyses. Of 1286 patients with known SMBG status, 70% reported using SMBG. Pre-prandial SMBG data were obtained from 554 participants and post-prandial SMBG data from 418. The mean SMBG result and HbA(1c) correlated significantly (pre-prandial r(s)=0.55, post-prandial r(s)=0.47; P<0.001). Areas under the ROC curve (95% confidence limits) were 0.78 (0.74-0.83) and 0.74 (0.69-0.78) for pre- and post-prandial SMBG (P<0.04). The optimal cut-point was 6.5 mmol/L for pre-prandial SMBG (sensitivity 79.3%, specificity 64.4%). Mean pre-prandial SMBG results correlated with FSG (r(s)=0.64, P<0.001) but were on average 1.4 mmol/L lower, consistent with known whole blood vs. plasma differences. Since SMBG values reflect prevailing glycaemia, refinements in their interpretation and application may improve SMBG effectiveness.

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Authors+Show Affiliations

Chubb SA
University of Western Australia, School of Pathology and Laboratory Medicine and Department of Biochemistry, PathWest Laboratory Medicine WA, Fremantle Hospital, Western Australia, Australia.
Van Minnen K
No affiliation info available
Davis WA
No affiliation info available
Bruce DG
No affiliation info available
Davis TM
No affiliation info available

MeSH

Blood GlucoseBlood Glucose Self-MonitoringDiabetes Mellitus, Type 2FastingFemaleFollow-Up StudiesGlycated Hemoglobin AHumansHypoglycemic AgentsInsulinLongitudinal StudiesMaleMiddle AgedPostprandial PeriodPrognosisROC Curve

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21862165

Citation

Chubb, S A Paul, et al. "The Relationship Between Self-monitoring of Blood Glucose Results and Glycated Haemoglobin in Type 2 Diabetes: the Fremantle Diabetes Study." Diabetes Research and Clinical Practice, vol. 94, no. 3, 2011, pp. 371-6.
Chubb SA, Van Minnen K, Davis WA, et al. The relationship between self-monitoring of blood glucose results and glycated haemoglobin in type 2 diabetes: the fremantle diabetes study. Diabetes Res Clin Pract. 2011;94(3):371-6.
Chubb, S. A., Van Minnen, K., Davis, W. A., Bruce, D. G., & Davis, T. M. (2011). The relationship between self-monitoring of blood glucose results and glycated haemoglobin in type 2 diabetes: the fremantle diabetes study. Diabetes Research and Clinical Practice, 94(3), 371-6. https://doi.org/10.1016/j.diabres.2011.07.038
Chubb SA, et al. The Relationship Between Self-monitoring of Blood Glucose Results and Glycated Haemoglobin in Type 2 Diabetes: the Fremantle Diabetes Study. Diabetes Res Clin Pract. 2011;94(3):371-6. PubMed PMID: 21862165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between self-monitoring of blood glucose results and glycated haemoglobin in type 2 diabetes: the fremantle diabetes study. AU - Chubb,S A Paul, AU - Van Minnen,Kylie, AU - Davis,Wendy A, AU - Bruce,David G, AU - Davis,Timothy M E, Y1 - 2011/09/08/ PY - 2011/03/15/received PY - 2011/07/26/accepted PY - 2011/8/25/entrez PY - 2011/8/25/pubmed PY - 2012/5/9/medline SP - 371 EP - 6 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 94 IS - 3 N2 - The benefits of self-monitoring of blood glucose (SMBG) in type 2 diabetes remain contentious. If SMBG data do not accurately reflect HbA(1c), attempts to modify lifestyle/pharmacotherapy will be ineffective. We aimed to determine how well SMBG correlates with HbA(1c) and fasting serum glucose (FSG). Community-based type 2 patients using SMBG provided their highest and lowest pre- and post-prandial glucose results in the week before detailed assessment. The ability of average pre- and post-prandial SMBG to predict HbA(1c)>7.0% was determined by linear regression and receiver operating characteristic (ROC) analyses. Of 1286 patients with known SMBG status, 70% reported using SMBG. Pre-prandial SMBG data were obtained from 554 participants and post-prandial SMBG data from 418. The mean SMBG result and HbA(1c) correlated significantly (pre-prandial r(s)=0.55, post-prandial r(s)=0.47; P<0.001). Areas under the ROC curve (95% confidence limits) were 0.78 (0.74-0.83) and 0.74 (0.69-0.78) for pre- and post-prandial SMBG (P<0.04). The optimal cut-point was 6.5 mmol/L for pre-prandial SMBG (sensitivity 79.3%, specificity 64.4%). Mean pre-prandial SMBG results correlated with FSG (r(s)=0.64, P<0.001) but were on average 1.4 mmol/L lower, consistent with known whole blood vs. plasma differences. Since SMBG values reflect prevailing glycaemia, refinements in their interpretation and application may improve SMBG effectiveness. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/21862165/The_relationship_between_self_monitoring_of_blood_glucose_results_and_glycated_haemoglobin_in_type_2_diabetes:_the_fremantle_diabetes_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(11)00414-1 DB - PRIME DP - Unbound Medicine ER -
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