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Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial.

Abstract

Recently, in a supplementation study over six months, it has been demonstrated that re-esterified omega-3 fatty acid triacylglycerols (n3-FA-rTAGs) led to a higher increase in omega-3-index compared to identical doses of n3-FA ethyl-esters (n3-FA-EEs), suggesting a better long-term bioavailability. The aim of this study was to examine whether differences occur between the two forms in affecting fasting serum lipid levels. 150 dyslipidemic statin-treated participants were randomized to corn oil as a placebo or fish oil either as rTAG or EE in identical doses (1.01g EPA+0.67g DHA). No changes in total cholesterol, HDL or LDL levels were observed. In the rTAG-group, but not in the EE-group, fasting serum TAG levels were significantly reduced from baseline after three and six months. There was no significant difference between the two n3-FA-groups. However, serum TAG levels were significantly lowered after six months in the rTAG-group compared to the placebo-group in contrast to the EE-group.

Authors+Show Affiliations

Institute of Food Science and Human Nutrition, Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hanover, Germany. schuchardt@nutrition.uni-hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

21862301

Citation

Schuchardt, J P., et al. "Moderate Doses of EPA and DHA From Re-esterified Triacylglycerols but Not From Ethyl-esters Lower Fasting Serum Triacylglycerols in Statin-treated Dyslipidemic Subjects: Results From a Six Month Randomized Controlled Trial." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 85, no. 6, 2011, pp. 381-6.
Schuchardt JP, Neubronner J, Kressel G, et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. Prostaglandins Leukot Essent Fatty Acids. 2011;85(6):381-6.
Schuchardt, J. P., Neubronner, J., Kressel, G., Merkel, M., von Schacky, C., & Hahn, A. (2011). Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 85(6), 381-6. https://doi.org/10.1016/j.plefa.2011.07.006
Schuchardt JP, et al. Moderate Doses of EPA and DHA From Re-esterified Triacylglycerols but Not From Ethyl-esters Lower Fasting Serum Triacylglycerols in Statin-treated Dyslipidemic Subjects: Results From a Six Month Randomized Controlled Trial. Prostaglandins Leukot Essent Fatty Acids. 2011;85(6):381-6. PubMed PMID: 21862301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. AU - Schuchardt,J P, AU - Neubronner,J, AU - Kressel,G, AU - Merkel,M, AU - von Schacky,C, AU - Hahn,A, Y1 - 2011/08/20/ PY - 2011/04/13/received PY - 2011/07/22/revised PY - 2011/07/25/accepted PY - 2011/8/25/entrez PY - 2011/8/25/pubmed PY - 2012/3/16/medline SP - 381 EP - 6 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 85 IS - 6 N2 - Recently, in a supplementation study over six months, it has been demonstrated that re-esterified omega-3 fatty acid triacylglycerols (n3-FA-rTAGs) led to a higher increase in omega-3-index compared to identical doses of n3-FA ethyl-esters (n3-FA-EEs), suggesting a better long-term bioavailability. The aim of this study was to examine whether differences occur between the two forms in affecting fasting serum lipid levels. 150 dyslipidemic statin-treated participants were randomized to corn oil as a placebo or fish oil either as rTAG or EE in identical doses (1.01g EPA+0.67g DHA). No changes in total cholesterol, HDL or LDL levels were observed. In the rTAG-group, but not in the EE-group, fasting serum TAG levels were significantly reduced from baseline after three and six months. There was no significant difference between the two n3-FA-groups. However, serum TAG levels were significantly lowered after six months in the rTAG-group compared to the placebo-group in contrast to the EE-group. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/21862301/Moderate_doses_of_EPA_and_DHA_from_re_esterified_triacylglycerols_but_not_from_ethyl_esters_lower_fasting_serum_triacylglycerols_in_statin_treated_dyslipidemic_subjects:_Results_from_a_six_month_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(11)00101-3 DB - PRIME DP - Unbound Medicine ER -