Tags

Type your tag names separated by a space and hit enter

[De-nol in NSAID-induced gastroduodenal lesions].
Minerva Dietol Gastroenterol. 1990 Jan-Mar; 36(1):27-30.MD

Abstract

It is well known that prolonged use of Non Steroidal Anti-inflammatory Drugs (NSAIDs) can trigger gastroduodenal lesions and/or their complications, even in the absence of any dramatic painful and dyspeptic symptomatology. The paper reports the results of a double-blind study carried out with Colloidal Bismuth Subcitrate (CBS, DE-NOL), an antiulcer drug with cytoprotective activity, versus ranitidine (RN) with the aim of assessing its therapeutic efficacy in promoting healing of either gastric or duodenal ulcers induced by NSAIDs. It is concluded that the efficacy of DE-NOL is comparable to that of RN, although some minor differences in healing rates were observed: these being in favour of DE-NOL in the gastric ulcer patients and in favour of RN in the duodenal ulcer patients, respectively. In addition, it is stated that in patients undergoing chronic treatment with NSAIDs the use of cytoprotective drugs as a preventive treatment as well as periodic endoscopic surveillance are more useful and rational in order to combat the onset of NSAIDs-induced side-effects, given the frequent paucity of symptomatology following the occurrence of gastroduodenal lesions.

Authors+Show Affiliations

Istituto di Clinica Medica B, Università degli Studi di Palermo.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
English Abstract
Journal Article

Language

ita

PubMed ID

2186304

Citation

Cataldo, M G., et al. "[De-nol in NSAID-induced Gastroduodenal Lesions]." Minerva Dietologica E Gastroenterologica, vol. 36, no. 1, 1990, pp. 27-30.
Cataldo MG, D'Aiuto A, Bongiorno A. [De-nol in NSAID-induced gastroduodenal lesions]. Minerva Dietol Gastroenterol. 1990;36(1):27-30.
Cataldo, M. G., D'Aiuto, A., & Bongiorno, A. (1990). [De-nol in NSAID-induced gastroduodenal lesions]. Minerva Dietologica E Gastroenterologica, 36(1), 27-30.
Cataldo MG, D'Aiuto A, Bongiorno A. [De-nol in NSAID-induced Gastroduodenal Lesions]. Minerva Dietol Gastroenterol. 1990 Jan-Mar;36(1):27-30. PubMed PMID: 2186304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [De-nol in NSAID-induced gastroduodenal lesions]. AU - Cataldo,M G, AU - D'Aiuto,A, AU - Bongiorno,A, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 27 EP - 30 JF - Minerva dietologica e gastroenterologica JO - Minerva Dietol Gastroenterol VL - 36 IS - 1 N2 - It is well known that prolonged use of Non Steroidal Anti-inflammatory Drugs (NSAIDs) can trigger gastroduodenal lesions and/or their complications, even in the absence of any dramatic painful and dyspeptic symptomatology. The paper reports the results of a double-blind study carried out with Colloidal Bismuth Subcitrate (CBS, DE-NOL), an antiulcer drug with cytoprotective activity, versus ranitidine (RN) with the aim of assessing its therapeutic efficacy in promoting healing of either gastric or duodenal ulcers induced by NSAIDs. It is concluded that the efficacy of DE-NOL is comparable to that of RN, although some minor differences in healing rates were observed: these being in favour of DE-NOL in the gastric ulcer patients and in favour of RN in the duodenal ulcer patients, respectively. In addition, it is stated that in patients undergoing chronic treatment with NSAIDs the use of cytoprotective drugs as a preventive treatment as well as periodic endoscopic surveillance are more useful and rational in order to combat the onset of NSAIDs-induced side-effects, given the frequent paucity of symptomatology following the occurrence of gastroduodenal lesions. SN - 0391-1993 UR - https://www.unboundmedicine.com/medline/citation/2186304/[De_nol_in_NSAID_induced_gastroduodenal_lesions]_ DB - PRIME DP - Unbound Medicine ER -