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A novel influenza A H1N1 clinical manifestations in patients at Chiang Mai University Hospital.
J Med Assoc Thai. 2011 Aug; 94(8):908-15.JM

Abstract

OBJECTIVE

To describe the clinical manifestations of patients affected with a novel influenza A (H1N1 2009) during the pandemic.

MATERIAL AND METHOD

A retrospective study was conducted in patients with influenza-like illness receiving care at Chiang Mai University Hospital between June 1 and September 30, 2009. The inclusion criteria were as follows 1) patients had influenza-like illness that was defined as fever, with cough and/or sore throat, 2) detection of influenza A H1N1 2009 by real-time polymerase chain reaction (RT-PCR) from nasopharyngeal swabs or throat swabs.

RESULTS

Among 278 patients, 150 patients (54.0%) were male and the mean age was 21.4 +/- 13.1 years (range 1-74). Eighty-seven patients (31.3%) were in age group 15-19 years. Fifty-eight patients (20.9%) had underlying diseases and asthma was the most common health problem. The presenting symptoms were cough (dry or productive) (248 patients, 89.2%), fever > or = 38.0 degrees C (229 patients, 82.4%), sore throat (195 patients, 70.1%), rhinorrhea (126 patients, 45.3%) and myalgia (113 patients, 40.6%). Five patients had co-infection at admission, three patients had dengue hemorrhagic fever, one patient had mycoplasma infection, and the other one with Acinetobacter lwoffi bacteremia. One hundred forty four patients (51.8%) received oseltamivir. Two hundred seventy two patients (97.8%) recovered without complications. One pregnant-woman developed severe pre-eclampsia five days after the first symptom, one patient developed Guillain Barre syndrome 10 days after the first symptoms. Four patients died, all had pneumonia.

CONCLUSION

Younger people were more likely to be infected with influenza A H1N1 2009. The clinical manifestations were similar to the seasonal influenza. However, the mortality rate was much higher, particularly in patients who developed pneumonia. In this study, all patients who died had existing underlying medical conditions.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21863671

Citation

Chaiwarith, Romanee, et al. "A Novel Influenza a H1N1 Clinical Manifestations in Patients at Chiang Mai University Hospital." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 94, no. 8, 2011, pp. 908-15.
Chaiwarith R, Prommee N, Liwsrisakun C, et al. A novel influenza A H1N1 clinical manifestations in patients at Chiang Mai University Hospital. J Med Assoc Thai. 2011;94(8):908-15.
Chaiwarith, R., Prommee, N., Liwsrisakun, C., Oberdorfer, P., Nuntachit, N., & Pothirat, C. (2011). A novel influenza A H1N1 clinical manifestations in patients at Chiang Mai University Hospital. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 94(8), 908-15.
Chaiwarith R, et al. A Novel Influenza a H1N1 Clinical Manifestations in Patients at Chiang Mai University Hospital. J Med Assoc Thai. 2011;94(8):908-15. PubMed PMID: 21863671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel influenza A H1N1 clinical manifestations in patients at Chiang Mai University Hospital. AU - Chaiwarith,Romanee, AU - Prommee,Nippit, AU - Liwsrisakun,Chalerm, AU - Oberdorfer,Peninah, AU - Nuntachit,Nontakan, AU - Pothirat,Chaicharn, PY - 2011/8/26/entrez PY - 2011/8/26/pubmed PY - 2011/9/9/medline SP - 908 EP - 15 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 94 IS - 8 N2 - OBJECTIVE: To describe the clinical manifestations of patients affected with a novel influenza A (H1N1 2009) during the pandemic. MATERIAL AND METHOD: A retrospective study was conducted in patients with influenza-like illness receiving care at Chiang Mai University Hospital between June 1 and September 30, 2009. The inclusion criteria were as follows 1) patients had influenza-like illness that was defined as fever, with cough and/or sore throat, 2) detection of influenza A H1N1 2009 by real-time polymerase chain reaction (RT-PCR) from nasopharyngeal swabs or throat swabs. RESULTS: Among 278 patients, 150 patients (54.0%) were male and the mean age was 21.4 +/- 13.1 years (range 1-74). Eighty-seven patients (31.3%) were in age group 15-19 years. Fifty-eight patients (20.9%) had underlying diseases and asthma was the most common health problem. The presenting symptoms were cough (dry or productive) (248 patients, 89.2%), fever > or = 38.0 degrees C (229 patients, 82.4%), sore throat (195 patients, 70.1%), rhinorrhea (126 patients, 45.3%) and myalgia (113 patients, 40.6%). Five patients had co-infection at admission, three patients had dengue hemorrhagic fever, one patient had mycoplasma infection, and the other one with Acinetobacter lwoffi bacteremia. One hundred forty four patients (51.8%) received oseltamivir. Two hundred seventy two patients (97.8%) recovered without complications. One pregnant-woman developed severe pre-eclampsia five days after the first symptom, one patient developed Guillain Barre syndrome 10 days after the first symptoms. Four patients died, all had pneumonia. CONCLUSION: Younger people were more likely to be infected with influenza A H1N1 2009. The clinical manifestations were similar to the seasonal influenza. However, the mortality rate was much higher, particularly in patients who developed pneumonia. In this study, all patients who died had existing underlying medical conditions. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/21863671/A_novel_influenza_A_H1N1_clinical_manifestations_in_patients_at_Chiang_Mai_University_Hospital_ L2 - https://medlineplus.gov/flu.html DB - PRIME DP - Unbound Medicine ER -