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Acute and chronic changes in diffusivity measures after sports concussion.
J Neurotrauma. 2011 Oct; 28(10):2049-59.JN

Abstract

Despite negative neuroimaging findings in concussed athletes, studies indicate that the acceleration and deceleration of the brain after concussive impacts result in metabolic and electrophysiological alterations that may be attributable to changes in white matter resulting from biomechanical strain. In the present study we investigated the effects of sports concussion on white matter using three different diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), mean diffusivity (MD), and axial diffusivity (AD). We compared a group of 10 non-concussed athletes with a group of 18 concussed athletes of the same age (mean age 22.5 years) and education (mean 16 years) using a voxel-based approach (VBA) in both the acute and chronic post-injury phases. All concussed athletes were scanned 1-6 days post-concussion and again 6 months later in a 3T Siemens Trio(™) MRI. Three 2×2 repeated-measures analyses of variance (ANOVAs) were conducted, one for each measure of DTI used in the current study. There was a main group effect of FA, which was increased in dorsal regions of both corticospinal tracts (CST) and in the corpus callosum in concussed athletes at both time points. There was a main group effect of AD in the right CST, where concussed athletes showed elevated values relative to controls at both time points. MD values were decreased in concussed athletes, in whom analyses revealed significant group differences in the CST and corpus callosum at both time points. Although the use of VBA does limit the analyses to large tracts, and it has clinical limitations with regard to individual analyses, our results nevertheless indicate that sports concussions do result in changes in diffusivity in the corpus callosum and CST that are not detected using conventional neuroimaging techniques.

Authors+Show Affiliations

Département de Psychology, Université de Montréal, Montréal, Québec, Canada. luke.henry@umontreal.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21864134

Citation

Henry, Luke C., et al. "Acute and Chronic Changes in Diffusivity Measures After Sports Concussion." Journal of Neurotrauma, vol. 28, no. 10, 2011, pp. 2049-59.
Henry LC, Tremblay J, Tremblay S, et al. Acute and chronic changes in diffusivity measures after sports concussion. J Neurotrauma. 2011;28(10):2049-59.
Henry, L. C., Tremblay, J., Tremblay, S., Lee, A., Brun, C., Lepore, N., Theoret, H., Ellemberg, D., & Lassonde, M. (2011). Acute and chronic changes in diffusivity measures after sports concussion. Journal of Neurotrauma, 28(10), 2049-59. https://doi.org/10.1089/neu.2011.1836
Henry LC, et al. Acute and Chronic Changes in Diffusivity Measures After Sports Concussion. J Neurotrauma. 2011;28(10):2049-59. PubMed PMID: 21864134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute and chronic changes in diffusivity measures after sports concussion. AU - Henry,Luke C, AU - Tremblay,Julie, AU - Tremblay,Sebastien, AU - Lee,Agatha, AU - Brun,Caroline, AU - Lepore,Natasha, AU - Theoret,Hugo, AU - Ellemberg,Dave, AU - Lassonde,Maryse, Y1 - 2011/10/04/ PY - 2011/8/26/entrez PY - 2011/8/26/pubmed PY - 2012/2/7/medline SP - 2049 EP - 59 JF - Journal of neurotrauma JO - J Neurotrauma VL - 28 IS - 10 N2 - Despite negative neuroimaging findings in concussed athletes, studies indicate that the acceleration and deceleration of the brain after concussive impacts result in metabolic and electrophysiological alterations that may be attributable to changes in white matter resulting from biomechanical strain. In the present study we investigated the effects of sports concussion on white matter using three different diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), mean diffusivity (MD), and axial diffusivity (AD). We compared a group of 10 non-concussed athletes with a group of 18 concussed athletes of the same age (mean age 22.5 years) and education (mean 16 years) using a voxel-based approach (VBA) in both the acute and chronic post-injury phases. All concussed athletes were scanned 1-6 days post-concussion and again 6 months later in a 3T Siemens Trio(™) MRI. Three 2×2 repeated-measures analyses of variance (ANOVAs) were conducted, one for each measure of DTI used in the current study. There was a main group effect of FA, which was increased in dorsal regions of both corticospinal tracts (CST) and in the corpus callosum in concussed athletes at both time points. There was a main group effect of AD in the right CST, where concussed athletes showed elevated values relative to controls at both time points. MD values were decreased in concussed athletes, in whom analyses revealed significant group differences in the CST and corpus callosum at both time points. Although the use of VBA does limit the analyses to large tracts, and it has clinical limitations with regard to individual analyses, our results nevertheless indicate that sports concussions do result in changes in diffusivity in the corpus callosum and CST that are not detected using conventional neuroimaging techniques. SN - 1557-9042 UR - https://www.unboundmedicine.com/medline/citation/21864134/Acute_and_chronic_changes_in_diffusivity_measures_after_sports_concussion_ L2 - https://www.liebertpub.com/doi/10.1089/neu.2011.1836?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -