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Effectiveness of theta-burst repetitive transcranial magnetic stimulation for treating chronic tinnitus.
Audiol Neurootol. 2012; 17(2):112-20.AN

Abstract

OBJECTIVES

Repetitive transcranial magnetic stimulation (rTMS), a noninvasive method for altering cortical excitability, is becoming a therapeutic strategy in auditory research institutions worldwide. Application of inhibiting rTMS on these overactive cortical regions can result in effective tinnitus suppression. The aim of this study is to investigate the efficacy of theta-burst rTMS in patients with chronic tinnitus.

STUDY DESIGN

Parallel randomized control study.

SETTING

Tertiary referral center.

PATIENTS

We enrolled 2 female and 20 male patients in this study. The evaluative tools included tinnitus frequency- and loudness-matching, tinnitus questionnaires (TQ), and the Tinnitus Handicap Inventory (THI).

METHODS

The orthogonal projection of the auditory cortex on the scalp was focalized. A figure-eight coil was placed on the surface of the skull over the targeted region with the intensity setting at 80% of the resting motor threshold. We delivered 900 pulses of theta-burst rTMS daily for 10 business days.

MAIN OUTCOME MEASURES

Nine of twelve patients (75%) in the active-stimulation group reported tinnitus suppression following treatment with rTMS. The treatment led to reductions of 8.58 and 8.33 in the mean TQ global and THI scores, respectively. Tinnitus loudness also decreased significantly after delivering rTMS.

RESULTS

Descriptive analysis of the TQs revealed that patients experienced significant improvements in emotional distress levels and somatic symptoms.

CONCLUSIONS

Our preliminary results demonstrate that theta-burst rTMS treatments offer a method of modulating tinnitus. Patients could benefit from emotional improvements, even more than auditory perceptive relief. Further studies are needed to establish a standard protocol and to clarify nervous propagation along the auditory and psychological projection following treatment with rTMS.

Authors+Show Affiliations

Department of Otorhinolaryngology - Head and Neck Surgery, China Medical University Hospital, Taichung City, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21865723

Citation

Chung, Hsiung-Kwang, et al. "Effectiveness of Theta-burst Repetitive Transcranial Magnetic Stimulation for Treating Chronic Tinnitus." Audiology & Neuro-otology, vol. 17, no. 2, 2012, pp. 112-20.
Chung HK, Tsai CH, Lin YC, et al. Effectiveness of theta-burst repetitive transcranial magnetic stimulation for treating chronic tinnitus. Audiol Neurootol. 2012;17(2):112-20.
Chung, H. K., Tsai, C. H., Lin, Y. C., Chen, J. M., Tsou, Y. A., Wang, C. Y., Lin, C. D., Jeng, F. C., Chung, J. G., & Tsai, M. H. (2012). Effectiveness of theta-burst repetitive transcranial magnetic stimulation for treating chronic tinnitus. Audiology & Neuro-otology, 17(2), 112-20. https://doi.org/10.1159/000330882
Chung HK, et al. Effectiveness of Theta-burst Repetitive Transcranial Magnetic Stimulation for Treating Chronic Tinnitus. Audiol Neurootol. 2012;17(2):112-20. PubMed PMID: 21865723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of theta-burst repetitive transcranial magnetic stimulation for treating chronic tinnitus. AU - Chung,Hsiung-Kwang, AU - Tsai,Chon-Haw, AU - Lin,Yu-Chin, AU - Chen,Jin-Ming, AU - Tsou,Yung-An, AU - Wang,Chin-Yuan, AU - Lin,Chia-Der, AU - Jeng,Fuh-Cherng, AU - Chung,Jing-Gung, AU - Tsai,Ming-Hsui, Y1 - 2011/03/11/ PY - 2011/8/26/entrez PY - 2011/8/26/pubmed PY - 2012/5/31/medline SP - 112 EP - 20 JF - Audiology & neuro-otology JO - Audiol Neurootol VL - 17 IS - 2 N2 - OBJECTIVES: Repetitive transcranial magnetic stimulation (rTMS), a noninvasive method for altering cortical excitability, is becoming a therapeutic strategy in auditory research institutions worldwide. Application of inhibiting rTMS on these overactive cortical regions can result in effective tinnitus suppression. The aim of this study is to investigate the efficacy of theta-burst rTMS in patients with chronic tinnitus. STUDY DESIGN: Parallel randomized control study. SETTING: Tertiary referral center. PATIENTS: We enrolled 2 female and 20 male patients in this study. The evaluative tools included tinnitus frequency- and loudness-matching, tinnitus questionnaires (TQ), and the Tinnitus Handicap Inventory (THI). METHODS: The orthogonal projection of the auditory cortex on the scalp was focalized. A figure-eight coil was placed on the surface of the skull over the targeted region with the intensity setting at 80% of the resting motor threshold. We delivered 900 pulses of theta-burst rTMS daily for 10 business days. MAIN OUTCOME MEASURES: Nine of twelve patients (75%) in the active-stimulation group reported tinnitus suppression following treatment with rTMS. The treatment led to reductions of 8.58 and 8.33 in the mean TQ global and THI scores, respectively. Tinnitus loudness also decreased significantly after delivering rTMS. RESULTS: Descriptive analysis of the TQs revealed that patients experienced significant improvements in emotional distress levels and somatic symptoms. CONCLUSIONS: Our preliminary results demonstrate that theta-burst rTMS treatments offer a method of modulating tinnitus. Patients could benefit from emotional improvements, even more than auditory perceptive relief. Further studies are needed to establish a standard protocol and to clarify nervous propagation along the auditory and psychological projection following treatment with rTMS. SN - 1421-9700 UR - https://www.unboundmedicine.com/medline/citation/21865723/Effectiveness_of_theta_burst_repetitive_transcranial_magnetic_stimulation_for_treating_chronic_tinnitus_ L2 - https://www.karger.com?DOI=10.1159/000330882 DB - PRIME DP - Unbound Medicine ER -