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Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort.

Abstract

The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.

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  • Authors+Show Affiliations

    ,

    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark. louhan@cancer.dk

    , , , , , , , , , , ,

    Source

    International journal of cancer 131:2 2012 Jul 15 pg 469-78

    MeSH

    Adult
    Cohort Studies
    Colonic Neoplasms
    Dietary Fiber
    Eating
    Edible Grain
    Feeding Behavior
    Female
    Fruit
    Humans
    Incidence
    Male
    Middle Aged
    Rectal Neoplasms
    Risk Factors
    Scandinavian and Nordic Countries
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21866547

    Citation

    Hansen, Louise, et al. "Intake of Dietary Fiber, Especially From Cereal Foods, Is Associated With Lower Incidence of Colon Cancer in the HELGA Cohort." International Journal of Cancer, vol. 131, no. 2, 2012, pp. 469-78.
    Hansen L, Skeie G, Landberg R, et al. Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort. Int J Cancer. 2012;131(2):469-78.
    Hansen, L., Skeie, G., Landberg, R., Lund, E., Palmqvist, R., Johansson, I., ... Olsen, A. (2012). Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort. International Journal of Cancer, 131(2), pp. 469-78. doi:10.1002/ijc.26381.
    Hansen L, et al. Intake of Dietary Fiber, Especially From Cereal Foods, Is Associated With Lower Incidence of Colon Cancer in the HELGA Cohort. Int J Cancer. 2012 Jul 15;131(2):469-78. PubMed PMID: 21866547.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort. AU - Hansen,Louise, AU - Skeie,Guri, AU - Landberg,Rikard, AU - Lund,Eiliv, AU - Palmqvist,Richard, AU - Johansson,Ingegerd, AU - Dragsted,Lars O, AU - Egeberg,Rikke, AU - Johnsen,Nina F, AU - Christensen,Jane, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Olsen,Anja, Y1 - 2011/10/20/ PY - 2011/01/27/received PY - 2011/07/05/accepted PY - 2011/8/26/entrez PY - 2011/8/26/pubmed PY - 2012/7/31/medline SP - 469 EP - 78 JF - International journal of cancer JO - Int. J. Cancer VL - 131 IS - 2 N2 - The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21866547/Intake_of_dietary_fiber_especially_from_cereal_foods_is_associated_with_lower_incidence_of_colon_cancer_in_the_HELGA_cohort_ L2 - https://doi.org/10.1002/ijc.26381 DB - PRIME DP - Unbound Medicine ER -