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Dietary acrylamide and risk of prostate cancer.
Int J Cancer 2012; 131(2):479-87IJ

Abstract

Acrylamide has been designated by IARC as a "probable human carcinogen." High levels are formed during cooking of many commonly consumed foods including French fries, potato chips, breakfast cereal and coffee. Two prospective cohort studies and two case-control studies in Europe found no association between acrylamide intake and prostate cancer. We examined this association in a large prospective cohort of 47,896 US men in the Health Professionals' Follow-up Study, using updated dietary acrylamide intake from food frequency questionnaires in 1986, 1990, 1994, 1998 and 2002. From 1986 through 2006, we documented 5025 cases of prostate cancer, and 642 lethal cancers. We used Cox proportional hazards models to assess the association between acrylamide intake from diet and prostate cancer risk overall as well as risk of advanced or lethal cancer. Acrylamide intake ranged from a mean of 10.5 mcg/day in the lowest quintile to 40.1 mcg/day in the highest quintile; coffee and potato products were largest contributors to intake. The multivariate-adjusted relative risk of prostate cancer was 1.02 (95% confidence interval: 0.92-1.13) for the highest versus lowest quintile of acrylamide intake (p-value for trend = 0.90). Results were similar when restricted to never smokers and to men who had prostate-specific antigen (PSA) tests. There was no significant association for dietary acrylamide and risk of lethal, advanced or high-grade disease, or for different latency periods ranging from 0-4 years to 12-16 years. We found no evidence that acrylamide intake, within the range of US diets, is associated with increased risk of prostate cancer.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. kwilson@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21866549

Citation

Wilson, Kathryn M., et al. "Dietary Acrylamide and Risk of Prostate Cancer." International Journal of Cancer, vol. 131, no. 2, 2012, pp. 479-87.
Wilson KM, Giovannucci E, Stampfer MJ, et al. Dietary acrylamide and risk of prostate cancer. Int J Cancer. 2012;131(2):479-87.
Wilson, K. M., Giovannucci, E., Stampfer, M. J., & Mucci, L. A. (2012). Dietary acrylamide and risk of prostate cancer. International Journal of Cancer, 131(2), pp. 479-87. doi:10.1002/ijc.26383.
Wilson KM, et al. Dietary Acrylamide and Risk of Prostate Cancer. Int J Cancer. 2012 Jul 15;131(2):479-87. PubMed PMID: 21866549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary acrylamide and risk of prostate cancer. AU - Wilson,Kathryn M, AU - Giovannucci,Edward, AU - Stampfer,Meir J, AU - Mucci,Lorelei A, Y1 - 2011/09/14/ PY - 2011/03/21/received PY - 2011/08/04/accepted PY - 2011/8/26/entrez PY - 2011/8/26/pubmed PY - 2012/7/31/medline SP - 479 EP - 87 JF - International journal of cancer JO - Int. J. Cancer VL - 131 IS - 2 N2 - Acrylamide has been designated by IARC as a "probable human carcinogen." High levels are formed during cooking of many commonly consumed foods including French fries, potato chips, breakfast cereal and coffee. Two prospective cohort studies and two case-control studies in Europe found no association between acrylamide intake and prostate cancer. We examined this association in a large prospective cohort of 47,896 US men in the Health Professionals' Follow-up Study, using updated dietary acrylamide intake from food frequency questionnaires in 1986, 1990, 1994, 1998 and 2002. From 1986 through 2006, we documented 5025 cases of prostate cancer, and 642 lethal cancers. We used Cox proportional hazards models to assess the association between acrylamide intake from diet and prostate cancer risk overall as well as risk of advanced or lethal cancer. Acrylamide intake ranged from a mean of 10.5 mcg/day in the lowest quintile to 40.1 mcg/day in the highest quintile; coffee and potato products were largest contributors to intake. The multivariate-adjusted relative risk of prostate cancer was 1.02 (95% confidence interval: 0.92-1.13) for the highest versus lowest quintile of acrylamide intake (p-value for trend = 0.90). Results were similar when restricted to never smokers and to men who had prostate-specific antigen (PSA) tests. There was no significant association for dietary acrylamide and risk of lethal, advanced or high-grade disease, or for different latency periods ranging from 0-4 years to 12-16 years. We found no evidence that acrylamide intake, within the range of US diets, is associated with increased risk of prostate cancer. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21866549/Dietary_acrylamide_and_risk_of_prostate_cancer_ L2 - https://doi.org/10.1002/ijc.26383 DB - PRIME DP - Unbound Medicine ER -