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Relation of serum insulin-like growth factor-1 (IGF-1) levels with hepatitis C virus infection and insulin resistance.
Transl Res. 2011 Sep; 158(3):155-62.TR

Abstract

The prospect of the growing worldwide epidemic of hepatitis C virus (HCV) infection and type 2 diabetes mellitus certainly merits attention toward their controversial relationship. Insulin-like growth factor-1 (IGF-1) plays an important role in glucose homeostasis. This study is a cross-sectional study considered as an initial investigation aimed to evaluate the effect of HCV infection on serum IGF-1, as well as to find out whether IGF-1 has a role in development of insulin resistance (IR) in HCV infection. A total of 45 subjects divided into 3 groups were included in the study: chronic HCV-infected patients (15 patients), chronic HCV-infected diabetic patients (15 patients), and diabetic patients without HCV infection (15 patients), along with 15 healthy controls. HCV RNA was quantified using real-time polymerase chain reaction (PCR). Serum IGF-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Homeostasis model assessment of insulin resistance [HOMA-IR], insulin sensitivity [HOMA-S], and β-cell function [HOMA-β] were determined by previously validated mathematic indexes. Fasting blood glucose, insulin levels, and liver parameters including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. IGF-1 levels were significantly lower in the 3 patient groups compared with controls (P = 0.001). The HCV group demonstrated high HOMA-IR and HOMA-β with a positive correlation between HOMA-IR and either HOMA-β or fasting insulin (P < 0.001). In addition, a negative correlation was found between IGF-1 levels and both AST and ALT, and HOMA-IR was correlated positively with AST activity (P < 0.05). In HCV patients with detectable viremia, IGF-1 levels were correlated negatively with HOMA-β (P < 0.01) and with HOMA-IR. However, this correlation did not reach statistical significance (P = 0.074). No significant correlation was found between HCV viral load and the studied parameters. In conclusion, low IGF-I levels might have a role in IR among HCV viremic patients.

Authors+Show Affiliations

Department of Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt. ghadafahmy@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21867981

Citation

Helaly, Ghada F., et al. "Relation of Serum Insulin-like Growth Factor-1 (IGF-1) Levels With Hepatitis C Virus Infection and Insulin Resistance." Translational Research : the Journal of Laboratory and Clinical Medicine, vol. 158, no. 3, 2011, pp. 155-62.
Helaly GF, Hussein NG, Refai W, et al. Relation of serum insulin-like growth factor-1 (IGF-1) levels with hepatitis C virus infection and insulin resistance. Transl Res. 2011;158(3):155-62.
Helaly, G. F., Hussein, N. G., Refai, W., & Ibrahim, M. (2011). Relation of serum insulin-like growth factor-1 (IGF-1) levels with hepatitis C virus infection and insulin resistance. Translational Research : the Journal of Laboratory and Clinical Medicine, 158(3), 155-62. https://doi.org/10.1016/j.trsl.2011.04.005
Helaly GF, et al. Relation of Serum Insulin-like Growth Factor-1 (IGF-1) Levels With Hepatitis C Virus Infection and Insulin Resistance. Transl Res. 2011;158(3):155-62. PubMed PMID: 21867981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of serum insulin-like growth factor-1 (IGF-1) levels with hepatitis C virus infection and insulin resistance. AU - Helaly,Ghada F, AU - Hussein,Nabila G, AU - Refai,Wael, AU - Ibrahim,Mervat, Y1 - 2011/05/30/ PY - 2010/06/19/received PY - 2011/04/22/revised PY - 2011/04/25/accepted PY - 2011/8/27/entrez PY - 2011/8/27/pubmed PY - 2011/10/15/medline SP - 155 EP - 62 JF - Translational research : the journal of laboratory and clinical medicine JO - Transl Res VL - 158 IS - 3 N2 - The prospect of the growing worldwide epidemic of hepatitis C virus (HCV) infection and type 2 diabetes mellitus certainly merits attention toward their controversial relationship. Insulin-like growth factor-1 (IGF-1) plays an important role in glucose homeostasis. This study is a cross-sectional study considered as an initial investigation aimed to evaluate the effect of HCV infection on serum IGF-1, as well as to find out whether IGF-1 has a role in development of insulin resistance (IR) in HCV infection. A total of 45 subjects divided into 3 groups were included in the study: chronic HCV-infected patients (15 patients), chronic HCV-infected diabetic patients (15 patients), and diabetic patients without HCV infection (15 patients), along with 15 healthy controls. HCV RNA was quantified using real-time polymerase chain reaction (PCR). Serum IGF-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Homeostasis model assessment of insulin resistance [HOMA-IR], insulin sensitivity [HOMA-S], and β-cell function [HOMA-β] were determined by previously validated mathematic indexes. Fasting blood glucose, insulin levels, and liver parameters including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. IGF-1 levels were significantly lower in the 3 patient groups compared with controls (P = 0.001). The HCV group demonstrated high HOMA-IR and HOMA-β with a positive correlation between HOMA-IR and either HOMA-β or fasting insulin (P < 0.001). In addition, a negative correlation was found between IGF-1 levels and both AST and ALT, and HOMA-IR was correlated positively with AST activity (P < 0.05). In HCV patients with detectable viremia, IGF-1 levels were correlated negatively with HOMA-β (P < 0.01) and with HOMA-IR. However, this correlation did not reach statistical significance (P = 0.074). No significant correlation was found between HCV viral load and the studied parameters. In conclusion, low IGF-I levels might have a role in IR among HCV viremic patients. SN - 1878-1810 UR - https://www.unboundmedicine.com/medline/citation/21867981/Relation_of_serum_insulin_like_growth_factor_1__IGF_1__levels_with_hepatitis_C_virus_infection_and_insulin_resistance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1931-5244(11)00156-3 DB - PRIME DP - Unbound Medicine ER -