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Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies.
Diabetes Care 2011; 34(9):2116-22DC

Abstract

OBJECTIVE

Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies.

RESEARCH DESIGN AND METHODS

We conducted a PubMed database search through January 2011 to identify prospective cohort studies of magnesium intake and risk of type 2 diabetes. Reference lists of retrieved articles were also reviewed. A random-effects model was used to compute the summary risk estimates.

RESULTS

Meta-analysis of 13 prospective cohort studies involving 536,318 participants and 24,516 cases detected a significant inverse association between magnesium intake and risk of type 2 diabetes (relative risk [RR] 0.78 [95% CI 0.73-0.84]). This association was not substantially modified by geographic region, follow-up length, sex, or family history of type 2 diabetes. A significant inverse association was observed in overweight (BMI ≥25 kg/m(2)) but not in normal-weight individuals (BMI <25 kg/m(2)), although test for interaction was not statistically significant (P(interaction) = 0.13). In the dose-response analysis, the summary RR of type 2 diabetes for every 100 mg/day increment in magnesium intake was 0.86 (95% CI 0.82-0.89). Sensitivity analyses restricted to studies with adjustment for cereal fiber intake yielded similar results. Little evidence of publication bias was observed.

CONCLUSIONS

This meta-analysis provides further evidence supporting that magnesium intake is significantly inversely associated with risk of type 2 diabetes in a dose-response manner.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, Soochow University, Suzhou, China. dongjy@mail3.sysu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21868780

Citation

Dong, Jia-Yi, et al. "Magnesium Intake and Risk of Type 2 Diabetes: Meta-analysis of Prospective Cohort Studies." Diabetes Care, vol. 34, no. 9, 2011, pp. 2116-22.
Dong JY, Xun P, He K, et al. Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies. Diabetes Care. 2011;34(9):2116-22.
Dong, J. Y., Xun, P., He, K., & Qin, L. Q. (2011). Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies. Diabetes Care, 34(9), pp. 2116-22. doi:10.2337/dc11-0518.
Dong JY, et al. Magnesium Intake and Risk of Type 2 Diabetes: Meta-analysis of Prospective Cohort Studies. Diabetes Care. 2011;34(9):2116-22. PubMed PMID: 21868780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies. AU - Dong,Jia-Yi, AU - Xun,Pengcheng, AU - He,Ka, AU - Qin,Li-Qiang, PY - 2011/8/27/entrez PY - 2011/8/27/pubmed PY - 2012/5/12/medline SP - 2116 EP - 22 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 9 N2 - OBJECTIVE: Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. RESEARCH DESIGN AND METHODS: We conducted a PubMed database search through January 2011 to identify prospective cohort studies of magnesium intake and risk of type 2 diabetes. Reference lists of retrieved articles were also reviewed. A random-effects model was used to compute the summary risk estimates. RESULTS: Meta-analysis of 13 prospective cohort studies involving 536,318 participants and 24,516 cases detected a significant inverse association between magnesium intake and risk of type 2 diabetes (relative risk [RR] 0.78 [95% CI 0.73-0.84]). This association was not substantially modified by geographic region, follow-up length, sex, or family history of type 2 diabetes. A significant inverse association was observed in overweight (BMI ≥25 kg/m(2)) but not in normal-weight individuals (BMI <25 kg/m(2)), although test for interaction was not statistically significant (P(interaction) = 0.13). In the dose-response analysis, the summary RR of type 2 diabetes for every 100 mg/day increment in magnesium intake was 0.86 (95% CI 0.82-0.89). Sensitivity analyses restricted to studies with adjustment for cereal fiber intake yielded similar results. Little evidence of publication bias was observed. CONCLUSIONS: This meta-analysis provides further evidence supporting that magnesium intake is significantly inversely associated with risk of type 2 diabetes in a dose-response manner. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/21868780/Magnesium_intake_and_risk_of_type_2_diabetes:_meta_analysis_of_prospective_cohort_studies_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=21868780 DB - PRIME DP - Unbound Medicine ER -