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[A case of curable encephalomyelitis in a tropical area: pernicious anemia].
Med Trop (Mars). 2011 Jun; 71(3):305-7.MT

Abstract

Pernicious anemia is uncommon in Africa. The purpose of this report is to describe a case of pernicious anemia observed in Madagascar. The revealing manifestation was encephalomyelitis with combined medullar sclerosis that responded favorably to vitamin B12 replacement therapy. Clinical symptoms included paresthesia associated with allodynia of all four extremities and with tetrapyramidal syndrome, medullar ataxia and minor cognitive disturbances ongoing for 5 months. Hemogram testing revealed macrocytic anemia. Serum cobalamin level was low. Anti-intrinsic factor antibody was detected. Spinal cord magnetic resonance imaging showed diffuse high-signal intensity along the posterior spinal cord extending from C1 to C4. Vitamin B12 replacement therapy led to full regression of clinical signs after six weeks. Association of central nervous system involvement with macrocytic anemia suggests vitamin B12 deficiency and pernicious anemia should be suspected. This disease can be considered as a curable form of myelitis in Africa and Madagascar.

Authors+Show Affiliations

Razafimahefa SH
Service d'hépato-gastro-entérologie, Hôpital de Befelatanana, Centre hospitalier universitaire d'Antananarivo, Madagascar.
Razafimahefa J
No affiliation info available
Rabenjanahary TH
No affiliation info available
Rakotoarivelo RA
No affiliation info available
Andriantseheno M
No affiliation info available
Ramanampamonjy RM
No affiliation info available
Rajaona HR
No affiliation info available

MeSH

Anemia, PerniciousEncephalomyelitisHumansMagnetic Resonance ImagingMaleMiddle AgedTropical ClimateVitamin B 12Vitamins

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

21870565

Citation

Razafimahefa, S H., et al. "[A Case of Curable Encephalomyelitis in a Tropical Area: Pernicious Anemia]." Medecine Tropicale : Revue Du Corps De Sante Colonial, vol. 71, no. 3, 2011, pp. 305-7.
Razafimahefa SH, Razafimahefa J, Rabenjanahary TH, et al. [A case of curable encephalomyelitis in a tropical area: pernicious anemia]. Med Trop (Mars). 2011;71(3):305-7.
Razafimahefa, S. H., Razafimahefa, J., Rabenjanahary, T. H., Rakotoarivelo, R. A., Andriantseheno, M., Ramanampamonjy, R. M., & Rajaona, H. R. (2011). [A case of curable encephalomyelitis in a tropical area: pernicious anemia]. Medecine Tropicale : Revue Du Corps De Sante Colonial, 71(3), 305-7.
Razafimahefa SH, et al. [A Case of Curable Encephalomyelitis in a Tropical Area: Pernicious Anemia]. Med Trop (Mars). 2011;71(3):305-7. PubMed PMID: 21870565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of curable encephalomyelitis in a tropical area: pernicious anemia]. AU - Razafimahefa,S H, AU - Razafimahefa,J, AU - Rabenjanahary,T H, AU - Rakotoarivelo,R A, AU - Andriantseheno,M, AU - Ramanampamonjy,R M, AU - Rajaona,H R, PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2011/11/4/medline SP - 305 EP - 7 JF - Medecine tropicale : revue du Corps de sante colonial JO - Med Trop (Mars) VL - 71 IS - 3 N2 - Pernicious anemia is uncommon in Africa. The purpose of this report is to describe a case of pernicious anemia observed in Madagascar. The revealing manifestation was encephalomyelitis with combined medullar sclerosis that responded favorably to vitamin B12 replacement therapy. Clinical symptoms included paresthesia associated with allodynia of all four extremities and with tetrapyramidal syndrome, medullar ataxia and minor cognitive disturbances ongoing for 5 months. Hemogram testing revealed macrocytic anemia. Serum cobalamin level was low. Anti-intrinsic factor antibody was detected. Spinal cord magnetic resonance imaging showed diffuse high-signal intensity along the posterior spinal cord extending from C1 to C4. Vitamin B12 replacement therapy led to full regression of clinical signs after six weeks. Association of central nervous system involvement with macrocytic anemia suggests vitamin B12 deficiency and pernicious anemia should be suspected. This disease can be considered as a curable form of myelitis in Africa and Madagascar. SN - 0025-682X UR - https://www.unboundmedicine.com/medline/citation/21870565/[A_case_of_curable_encephalomyelitis_in_a_tropical_area:_pernicious_anemia]_ L2 - http://www.diseaseinfosearch.org/result/2523 DB - PRIME DP - Unbound Medicine ER -