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The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women.
Gynecol Endocrinol. 2012 Mar; 28(3):203-7.GE

Abstract

OBJECTIVE

To evaluate the effect of red clover isoflavone supplementation over vasomotor and overall menopausal symptoms in postmenopausal women.

METHODS

One hundred and nine postmenopausal women aged 40 or more were assigned to randomly receive either two daily capsules of the active compound (80 mg red clover isoflavones, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Daily hot flush and night sweat frequency and overall menopausal symptom intensity (Kupperman Index) were measured at baseline, 90, 97 and 187 days.

RESULTS

Daily hot flush/night sweat frequency and Kupperman Index values were similar in both studied groups at baseline. All indices significantly decreased after red clover phase in Group A, corresponding, respectively to a 73.5%, 72.2% and 75.4% average decrement. These decrements were significantly higher than those observed for Group B after placebo phase (8.2%, 0.9% and 6.7% respectively). In Group A, after washout and placebo phases all values significantly increased. In Group B, all indices remained similar after placebo and washout phases, however significantly dropping after red clover treatment. These values were also significantly lower than those observed in Group A after placebo phase. No side effects were encountered after treatment with the active compound or placebo.

CONCLUSION

Red clover isoflavone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women.

Authors+Show Affiliations

Division of Obstetrics and Gynecology, General Teaching Hospital Korneuburg, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21870906

Citation

Lipovac, Markus, et al. "The Effect of Red Clover Isoflavone Supplementation Over Vasomotor and Menopausal Symptoms in Postmenopausal Women." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 28, no. 3, 2012, pp. 203-7.
Lipovac M, Chedraui P, Gruenhut C, et al. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Gynecol Endocrinol. 2012;28(3):203-7.
Lipovac, M., Chedraui, P., Gruenhut, C., Gocan, A., Kurz, C., Neuber, B., & Imhof, M. (2012). The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 28(3), 203-7. https://doi.org/10.3109/09513590.2011.593671
Lipovac M, et al. The Effect of Red Clover Isoflavone Supplementation Over Vasomotor and Menopausal Symptoms in Postmenopausal Women. Gynecol Endocrinol. 2012;28(3):203-7. PubMed PMID: 21870906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. AU - Lipovac,Markus, AU - Chedraui,Peter, AU - Gruenhut,Christine, AU - Gocan,Anca, AU - Kurz,Christine, AU - Neuber,Benedikt, AU - Imhof,Martin, Y1 - 2011/08/26/ PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/6/1/medline SP - 203 EP - 7 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 28 IS - 3 N2 - OBJECTIVE: To evaluate the effect of red clover isoflavone supplementation over vasomotor and overall menopausal symptoms in postmenopausal women. METHODS: One hundred and nine postmenopausal women aged 40 or more were assigned to randomly receive either two daily capsules of the active compound (80 mg red clover isoflavones, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Daily hot flush and night sweat frequency and overall menopausal symptom intensity (Kupperman Index) were measured at baseline, 90, 97 and 187 days. RESULTS: Daily hot flush/night sweat frequency and Kupperman Index values were similar in both studied groups at baseline. All indices significantly decreased after red clover phase in Group A, corresponding, respectively to a 73.5%, 72.2% and 75.4% average decrement. These decrements were significantly higher than those observed for Group B after placebo phase (8.2%, 0.9% and 6.7% respectively). In Group A, after washout and placebo phases all values significantly increased. In Group B, all indices remained similar after placebo and washout phases, however significantly dropping after red clover treatment. These values were also significantly lower than those observed in Group A after placebo phase. No side effects were encountered after treatment with the active compound or placebo. CONCLUSION: Red clover isoflavone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/21870906/The_effect_of_red_clover_isoflavone_supplementation_over_vasomotor_and_menopausal_symptoms_in_postmenopausal_women_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2011.593671 DB - PRIME DP - Unbound Medicine ER -