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Circadian rhythm of rest activity and autonomic nervous system activity at different stages in Parkinson's disease.
Auton Neurosci. 2011 Dec 07; 165(2):195-200.AN

Abstract

Patients with Parkinson's disease (PD) often suffer from non-motor symptoms, including sleep and autonomic dysfunctions, controlled by circadian regulation. To evaluate the alteration of circadian rhythm in PD patients, we investigated both rest activities and autonomic functions. Twenty-seven patients with idiopathic PD and 30 age-matched control subjects were recruited. Group comparisons of controls (mean age: 68.93 years), early-PD patients classified as Hoehn-Yahr (HY) stage 1&2 (mean age: 70.78 years), and advanced-PD as HY 3&4 (mean age: 68.61 years) were conducted. Measurement of rest activities was performed using Actigraph for 7 continuous days, and included measuring rhythm patterns (activity patterns recorded in or out of bed) and circadian rhythm amplitudes (power of the cycle being closest to 24h). A power spectral analysis of heart rate variability (HRV) using 24-hour ambulatory ECG was also performed. The actigraphic measurements indicated that statistically PD patients have lower activity levels when out of bed and higher activity levels when in bed, and that, the circadian rest-activity rhythm in PD decreases with disease severity. The HRV analysis showed that the total frequency component and low frequency/high frequency ratio were low in PD patients, suggesting that autonomic activities and the circadian rhythm of the sympathetic nervous system are attenuated in PD. This study elucidated the disorganization in the rest activities and HRV of PD patients as well as the gradual alterations in the circadian rhythm. The circadian rhythm disturbances are important to consider the mechanism of non-motor symptoms that occur from early stage of PD.

Authors+Show Affiliations

Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. bunniwa@koto.kpu-m.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21871844

Citation

Niwa, Fumitoshi, et al. "Circadian Rhythm of Rest Activity and Autonomic Nervous System Activity at Different Stages in Parkinson's Disease." Autonomic Neuroscience : Basic & Clinical, vol. 165, no. 2, 2011, pp. 195-200.
Niwa F, Kuriyama N, Nakagawa M, et al. Circadian rhythm of rest activity and autonomic nervous system activity at different stages in Parkinson's disease. Auton Neurosci. 2011;165(2):195-200.
Niwa, F., Kuriyama, N., Nakagawa, M., & Imanishi, J. (2011). Circadian rhythm of rest activity and autonomic nervous system activity at different stages in Parkinson's disease. Autonomic Neuroscience : Basic & Clinical, 165(2), 195-200. https://doi.org/10.1016/j.autneu.2011.07.010
Niwa F, et al. Circadian Rhythm of Rest Activity and Autonomic Nervous System Activity at Different Stages in Parkinson's Disease. Auton Neurosci. 2011 Dec 7;165(2):195-200. PubMed PMID: 21871844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian rhythm of rest activity and autonomic nervous system activity at different stages in Parkinson's disease. AU - Niwa,Fumitoshi, AU - Kuriyama,Nagato, AU - Nakagawa,Masanori, AU - Imanishi,Jiro, Y1 - 2011/08/25/ PY - 2011/04/18/received PY - 2011/07/07/revised PY - 2011/07/12/accepted PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/2/22/medline SP - 195 EP - 200 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 165 IS - 2 N2 - Patients with Parkinson's disease (PD) often suffer from non-motor symptoms, including sleep and autonomic dysfunctions, controlled by circadian regulation. To evaluate the alteration of circadian rhythm in PD patients, we investigated both rest activities and autonomic functions. Twenty-seven patients with idiopathic PD and 30 age-matched control subjects were recruited. Group comparisons of controls (mean age: 68.93 years), early-PD patients classified as Hoehn-Yahr (HY) stage 1&2 (mean age: 70.78 years), and advanced-PD as HY 3&4 (mean age: 68.61 years) were conducted. Measurement of rest activities was performed using Actigraph for 7 continuous days, and included measuring rhythm patterns (activity patterns recorded in or out of bed) and circadian rhythm amplitudes (power of the cycle being closest to 24h). A power spectral analysis of heart rate variability (HRV) using 24-hour ambulatory ECG was also performed. The actigraphic measurements indicated that statistically PD patients have lower activity levels when out of bed and higher activity levels when in bed, and that, the circadian rest-activity rhythm in PD decreases with disease severity. The HRV analysis showed that the total frequency component and low frequency/high frequency ratio were low in PD patients, suggesting that autonomic activities and the circadian rhythm of the sympathetic nervous system are attenuated in PD. This study elucidated the disorganization in the rest activities and HRV of PD patients as well as the gradual alterations in the circadian rhythm. The circadian rhythm disturbances are important to consider the mechanism of non-motor symptoms that occur from early stage of PD. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/21871844/Circadian_rhythm_of_rest_activity_and_autonomic_nervous_system_activity_at_different_stages_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(11)00382-1 DB - PRIME DP - Unbound Medicine ER -