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Distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban Sri Lanka.
Int J Gynaecol Obstet. 2011 Nov; 115(2):180-2.IJ

Abstract

OBJECTIVE

To identify the contributions of various human papillomavirus (HPV) genotypes in tissue samples from women diagnosed with cervical cancer in Sri Lanka.

METHODS

In a retrospective study, archival cervical tissues samples (n=108) obtained from Sri Lankan women diagnosed with histologically proven invasive squamous cell carcinoma between 2006 and 2007 were tested for HPV. Genotyping of HPV DNA was performed using an INNO-LiPA assay.

RESULTS

Overall, 93% of tumor samples tested positive for HPV DNA. HPV types 16 and 18 accounted collectively for 83.4% of the positive samples.

CONCLUSION

The findings suggest that the HPV genotypes responsible for causing cervical cancer in Sri Lanka are similar to those reported elsewhere worldwide. Consequently, women in Sri Lanka could benefit from currently available prophylactic HPV vaccines should they be implemented.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia. nirma.samarawickrema@monash.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21872246

Citation

Samarawickrema, Nirma A., et al. "Distribution of Human Papillomavirus Genotypes in Archival Cervical Tissue From Women With Cervical Cancer in Urban Sri Lanka." International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, vol. 115, no. 2, 2011, pp. 180-2.
Samarawickrema NA, Tabrizi SN, Hewavisenthi J, et al. Distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban Sri Lanka. Int J Gynaecol Obstet. 2011;115(2):180-2.
Samarawickrema, N. A., Tabrizi, S. N., Hewavisenthi, J., Leong, T., & Garland, S. M. (2011). Distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban Sri Lanka. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 115(2), 180-2. https://doi.org/10.1016/j.ijgo.2011.05.021
Samarawickrema NA, et al. Distribution of Human Papillomavirus Genotypes in Archival Cervical Tissue From Women With Cervical Cancer in Urban Sri Lanka. Int J Gynaecol Obstet. 2011;115(2):180-2. PubMed PMID: 21872246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban Sri Lanka. AU - Samarawickrema,Nirma A, AU - Tabrizi,Sepehr N, AU - Hewavisenthi,Janaki, AU - Leong,Trishe, AU - Garland,Suzanne M, Y1 - 2011/08/27/ PY - 2011/02/17/received PY - 2011/05/31/revised PY - 2011/07/25/accepted PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/1/18/medline SP - 180 EP - 2 JF - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JO - Int J Gynaecol Obstet VL - 115 IS - 2 N2 - OBJECTIVE: To identify the contributions of various human papillomavirus (HPV) genotypes in tissue samples from women diagnosed with cervical cancer in Sri Lanka. METHODS: In a retrospective study, archival cervical tissues samples (n=108) obtained from Sri Lankan women diagnosed with histologically proven invasive squamous cell carcinoma between 2006 and 2007 were tested for HPV. Genotyping of HPV DNA was performed using an INNO-LiPA assay. RESULTS: Overall, 93% of tumor samples tested positive for HPV DNA. HPV types 16 and 18 accounted collectively for 83.4% of the positive samples. CONCLUSION: The findings suggest that the HPV genotypes responsible for causing cervical cancer in Sri Lanka are similar to those reported elsewhere worldwide. Consequently, women in Sri Lanka could benefit from currently available prophylactic HPV vaccines should they be implemented. SN - 1879-3479 UR - https://www.unboundmedicine.com/medline/citation/21872246/Distribution_of_human_papillomavirus_genotypes_in_archival_cervical_tissue_from_women_with_cervical_cancer_in_urban_Sri_Lanka_ DB - PRIME DP - Unbound Medicine ER -