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Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.
Eur J Med Chem. 2011 Oct; 46(10):5206-11.EJ

Abstract

Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics.

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Authors+Show Affiliations

Sashidhara KV
Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), Chattar Manzil Palace, M.G. Marg, Lucknow 226001, India. sashidhar123@gmail.com
Singh SP
No affiliation info available
Srivastava A
No affiliation info available
Puri A
No affiliation info available
Chhonker YS
No affiliation info available
Bhatta RS
No affiliation info available
Shah P
No affiliation info available
Siddiqi MI
No affiliation info available

MeSH

AnimalsCricetinaeDiterpenes, ClerodaneHumansHydroxymethylglutaryl CoA ReductasesHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLipid MetabolismLipidsMaleModels, MolecularPlant ExtractsPolyalthia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21872367

Citation

Sashidhara, Koneni V., et al. "Discovery of a New Class of HMG-CoA Reductase Inhibitor From Polyalthia Longifolia as Potential Lipid Lowering Agent." European Journal of Medicinal Chemistry, vol. 46, no. 10, 2011, pp. 5206-11.
Sashidhara KV, Singh SP, Srivastava A, et al. Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. Eur J Med Chem. 2011;46(10):5206-11.
Sashidhara, K. V., Singh, S. P., Srivastava, A., Puri, A., Chhonker, Y. S., Bhatta, R. S., Shah, P., & Siddiqi, M. I. (2011). Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. European Journal of Medicinal Chemistry, 46(10), 5206-11. https://doi.org/10.1016/j.ejmech.2011.08.012
Sashidhara KV, et al. Discovery of a New Class of HMG-CoA Reductase Inhibitor From Polyalthia Longifolia as Potential Lipid Lowering Agent. Eur J Med Chem. 2011;46(10):5206-11. PubMed PMID: 21872367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. AU - Sashidhara,Koneni V, AU - Singh,Suriya P, AU - Srivastava,Anuj, AU - Puri,Anju, AU - Chhonker,Yashpal S, AU - Bhatta,Rabi S, AU - Shah,Priyanka, AU - Siddiqi,Mohammad Imran, Y1 - 2011/08/12/ PY - 2011/03/16/received PY - 2011/08/01/revised PY - 2011/08/04/accepted PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/2/18/medline SP - 5206 EP - 11 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 46 IS - 10 N2 - Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/21872367/Discovery_of_a_new_class_of_HMG_CoA_reductase_inhibitor_from_Polyalthia_longifolia_as_potential_lipid_lowering_agent_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(11)00584-8 DB - PRIME DP - Unbound Medicine ER -