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Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.
Eur J Med Chem. 2011 Oct; 46(10):5206-11.EJ

Abstract

Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics.

Authors+Show Affiliations

Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), Chattar Manzil Palace, M.G. Marg, Lucknow 226001, India. sashidhar123@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21872367

Citation

Sashidhara, Koneni V., et al. "Discovery of a New Class of HMG-CoA Reductase Inhibitor From Polyalthia Longifolia as Potential Lipid Lowering Agent." European Journal of Medicinal Chemistry, vol. 46, no. 10, 2011, pp. 5206-11.
Sashidhara KV, Singh SP, Srivastava A, et al. Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. Eur J Med Chem. 2011;46(10):5206-11.
Sashidhara, K. V., Singh, S. P., Srivastava, A., Puri, A., Chhonker, Y. S., Bhatta, R. S., Shah, P., & Siddiqi, M. I. (2011). Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. European Journal of Medicinal Chemistry, 46(10), 5206-11. https://doi.org/10.1016/j.ejmech.2011.08.012
Sashidhara KV, et al. Discovery of a New Class of HMG-CoA Reductase Inhibitor From Polyalthia Longifolia as Potential Lipid Lowering Agent. Eur J Med Chem. 2011;46(10):5206-11. PubMed PMID: 21872367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. AU - Sashidhara,Koneni V, AU - Singh,Suriya P, AU - Srivastava,Anuj, AU - Puri,Anju, AU - Chhonker,Yashpal S, AU - Bhatta,Rabi S, AU - Shah,Priyanka, AU - Siddiqi,Mohammad Imran, Y1 - 2011/08/12/ PY - 2011/03/16/received PY - 2011/08/01/revised PY - 2011/08/04/accepted PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/2/18/medline SP - 5206 EP - 11 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 46 IS - 10 N2 - Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/21872367/Discovery_of_a_new_class_of_HMG_CoA_reductase_inhibitor_from_Polyalthia_longifolia_as_potential_lipid_lowering_agent_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(11)00584-8 DB - PRIME DP - Unbound Medicine ER -