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Vitamin D in chronic kidney disease.
Best Pract Res Clin Endocrinol Metab. 2011 Aug; 25(4):647-55.BP

Abstract

In chronic kidney disease (CKD), abnormalities in vitamin D metabolism contribute to the development of mineral and skeletal disorders, elevations in parathyroid hormone (PTH), hypertension, systemic inflammation, renal and cardiovascular damage. CKD induces a progressive loss of the capacity of the kidney not only to convert 25-hydroxyvitamin D [25(OH)D] to circulating calcitriol, the vitamin D hormone, but also to maintain serum 25(OH)D levels for non-renal calcitriol synthesis. The resulting calcitriol and 25(OH)D deficiency associates directly with accelerated disease progression and death. This chapter presents our understanding of the pathophysiology behind 25(OH)D and calcitriol deficiency in CKD, of the adequacy of current recommendations for vitamin D supplementation and PTH suppression, and of potential markers of renal and cardiovascular lesions unrelated to PTH suppression, a knowledge required for the design of trials to obtain evidence-based recommendations for vitamin D and calcitriol replacement that improve outcomes at all stages of CKD.

Authors+Show Affiliations

Division of Experimental Nephrology, IRBLleida (Lleida Institute for Biomedical Research), Avda Rovira Roure 80, Lleida, Spain. adusso@irblleida.catNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21872805

Citation

Dusso, Adriana, et al. "Vitamin D in Chronic Kidney Disease." Best Practice & Research. Clinical Endocrinology & Metabolism, vol. 25, no. 4, 2011, pp. 647-55.
Dusso A, González EA, Martin KJ. Vitamin D in chronic kidney disease. Best Pract Res Clin Endocrinol Metab. 2011;25(4):647-55.
Dusso, A., González, E. A., & Martin, K. J. (2011). Vitamin D in chronic kidney disease. Best Practice & Research. Clinical Endocrinology & Metabolism, 25(4), 647-55. https://doi.org/10.1016/j.beem.2011.05.005
Dusso A, González EA, Martin KJ. Vitamin D in Chronic Kidney Disease. Best Pract Res Clin Endocrinol Metab. 2011;25(4):647-55. PubMed PMID: 21872805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D in chronic kidney disease. AU - Dusso,Adriana, AU - González,Esther A, AU - Martin,Kevin J, PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/1/4/medline SP - 647 EP - 55 JF - Best practice & research. Clinical endocrinology & metabolism JO - Best Pract Res Clin Endocrinol Metab VL - 25 IS - 4 N2 - In chronic kidney disease (CKD), abnormalities in vitamin D metabolism contribute to the development of mineral and skeletal disorders, elevations in parathyroid hormone (PTH), hypertension, systemic inflammation, renal and cardiovascular damage. CKD induces a progressive loss of the capacity of the kidney not only to convert 25-hydroxyvitamin D [25(OH)D] to circulating calcitriol, the vitamin D hormone, but also to maintain serum 25(OH)D levels for non-renal calcitriol synthesis. The resulting calcitriol and 25(OH)D deficiency associates directly with accelerated disease progression and death. This chapter presents our understanding of the pathophysiology behind 25(OH)D and calcitriol deficiency in CKD, of the adequacy of current recommendations for vitamin D supplementation and PTH suppression, and of potential markers of renal and cardiovascular lesions unrelated to PTH suppression, a knowledge required for the design of trials to obtain evidence-based recommendations for vitamin D and calcitriol replacement that improve outcomes at all stages of CKD. SN - 1878-1594 UR - https://www.unboundmedicine.com/medline/citation/21872805/Vitamin_D_in_chronic_kidney_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-690X(11)00055-8 DB - PRIME DP - Unbound Medicine ER -