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Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study.
Diabetes Care. 2011 Oct; 34(10):2300-5.DC

Abstract

OBJECTIVE

The aim of this study was to evaluate whether diabetes (DM) and impaired fasting glucose (IFG) were associated with early alterations in left ventricular geometry and function in a large population of adolescents and young adults independently of major confounders.

RESEARCH DESIGN AND METHODS

We analyzed echocardiographic data of 1,624 14- to 39-year-old participants (mean age 26.6 ± 7.7 years; 57% female) without prevalent cardiovascular disease from the fourth Strong Heart Study examination; 179 (11%) participants had DM and 299 (18%) had IFG.

RESULTS

Participants with DM and IFG were older and more often obese and hypertensive than participants with normal fasting glucose (NFG) (all P < 0.05). After adjustment for age, sex, systolic blood pressure, and body fat, diabetic and IFG participants had higher left ventricular mass index than those with NFG (41.5 ± 8.7 and 39.6 ± 9.2 vs. 35.6 ± 7.8 g/m(2.7)) and reduced stress-corrected midwall shortening (98 ± 8.6 and 99 ± 7.5 vs. 101 ± 8.5%; all P < 0.05). The prevalence of left ventricular hypertrophy was higher in DM (20%) and IFG (17%) than in NFG participants (12%; P < 0.05). Compared with the other groups, DM was also associated with higher prevalence of inappropriate left ventricular mass, concentric geometry, and more diastolic abnormalities independently of covariates (all P < 0.05).

CONCLUSIONS

In a population of adolescents and young adults, DM is independently associated with early unfavorable cardiovascular phenotype characterized by increased left ventricular mass, concentric geometry, and early preclinical systolic and diastolic dysfunction; early cardiovascular alterations are also present in participants with prediabetes.

Authors+Show Affiliations

Department of Clinical and Experimental Disease, Federico II University Hospital, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21873564

Citation

De Marco, Marina, et al. "Cardiac Geometry and Function in Diabetic or Prediabetic Adolescents and Young Adults: the Strong Heart Study." Diabetes Care, vol. 34, no. 10, 2011, pp. 2300-5.
De Marco M, de Simone G, Roman MJ, et al. Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study. Diabetes Care. 2011;34(10):2300-5.
De Marco, M., de Simone, G., Roman, M. J., Chinali, M., Lee, E. T., Calhoun, D., Howard, B. V., & Devereux, R. B. (2011). Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study. Diabetes Care, 34(10), 2300-5. https://doi.org/10.2337/dc11-0191
De Marco M, et al. Cardiac Geometry and Function in Diabetic or Prediabetic Adolescents and Young Adults: the Strong Heart Study. Diabetes Care. 2011;34(10):2300-5. PubMed PMID: 21873564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study. AU - De Marco,Marina, AU - de Simone,Giovanni, AU - Roman,Mary J, AU - Chinali,Marcello, AU - Lee,Elisa T, AU - Calhoun,Darren, AU - Howard,Barbara V, AU - Devereux,Richard B, Y1 - 2011/08/26/ PY - 2011/8/30/entrez PY - 2011/8/30/pubmed PY - 2012/5/12/medline SP - 2300 EP - 5 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 10 N2 - OBJECTIVE: The aim of this study was to evaluate whether diabetes (DM) and impaired fasting glucose (IFG) were associated with early alterations in left ventricular geometry and function in a large population of adolescents and young adults independently of major confounders. RESEARCH DESIGN AND METHODS: We analyzed echocardiographic data of 1,624 14- to 39-year-old participants (mean age 26.6 ± 7.7 years; 57% female) without prevalent cardiovascular disease from the fourth Strong Heart Study examination; 179 (11%) participants had DM and 299 (18%) had IFG. RESULTS: Participants with DM and IFG were older and more often obese and hypertensive than participants with normal fasting glucose (NFG) (all P < 0.05). After adjustment for age, sex, systolic blood pressure, and body fat, diabetic and IFG participants had higher left ventricular mass index than those with NFG (41.5 ± 8.7 and 39.6 ± 9.2 vs. 35.6 ± 7.8 g/m(2.7)) and reduced stress-corrected midwall shortening (98 ± 8.6 and 99 ± 7.5 vs. 101 ± 8.5%; all P < 0.05). The prevalence of left ventricular hypertrophy was higher in DM (20%) and IFG (17%) than in NFG participants (12%; P < 0.05). Compared with the other groups, DM was also associated with higher prevalence of inappropriate left ventricular mass, concentric geometry, and more diastolic abnormalities independently of covariates (all P < 0.05). CONCLUSIONS: In a population of adolescents and young adults, DM is independently associated with early unfavorable cardiovascular phenotype characterized by increased left ventricular mass, concentric geometry, and early preclinical systolic and diastolic dysfunction; early cardiovascular alterations are also present in participants with prediabetes. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/21873564/Cardiac_geometry_and_function_in_diabetic_or_prediabetic_adolescents_and_young_adults:_the_Strong_Heart_Study_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=21873564 DB - PRIME DP - Unbound Medicine ER -